Design, Preclinical Evaluation, and Clinical Translation of 68Ga-FAPI-LM3, a Heterobivalent Molecule for PET Imaging of Nasopharyngeal Carcinoma

Liang Zhao; Yizhen Pang; Jianyang Fang; Jianhao Chen; Yangfan Zhou; Long Sun; Hua Wu; Zhide Guo; Qin Lin; Haojun Chen

doi:10.2967/jnumed.123.266183

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Design, Preclinical Evaluation, and Clinical Translation of ⁶⁸Ga-FAPI-LM3, a Heterobivalent Molecule for PET Imaging of Nasopharyngeal Carcinoma

Liang Zhao, Yizhen Pang, Jianyang Fang, Jianhao Chen, Yangfan Zhou, Long Sun, Hua Wu, Zhide Guo, Qin Lin and Haojun Chen

Journal of Nuclear Medicine March 2024, 65 (3) 394-401; DOI: https://doi.org/10.2967/jnumed.123.266183

Liang Zhao

1Department of Nuclear Medicine and Minnan PET Center, Xiamen Key Laboratory of Radiopharmaceuticals, First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China;

2School of Clinical Medicine, Fujian Medical University, Fuzhou, China;

3Xiamen Key Laboratory of Radiation Oncology, Department of Radiation Oncology, Xiamen Cancer Center, First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China;

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Yizhen Pang

2School of Clinical Medicine, Fujian Medical University, Fuzhou, China;

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Jianyang Fang

4State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China; and

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Jianhao Chen

2School of Clinical Medicine, Fujian Medical University, Fuzhou, China;

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Yangfan Zhou

2School of Clinical Medicine, Fujian Medical University, Fuzhou, China;

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Long Sun

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Hua Wu

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Zhide Guo

4State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China; and

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Qin Lin

2School of Clinical Medicine, Fujian Medical University, Fuzhou, China;

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Haojun Chen

5Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials, Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen, China

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Journal of Nuclear Medicine

Vol. 65, Issue 3

March 1, 2024

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Design, Preclinical Evaluation, and Clinical Translation of ⁶⁸Ga-FAPI-LM3, a Heterobivalent Molecule for PET Imaging of Nasopharyngeal Carcinoma

Liang Zhao, Yizhen Pang, Jianyang Fang, Jianhao Chen, Yangfan Zhou, Long Sun, Hua Wu, Zhide Guo, Qin Lin, Haojun Chen

Journal of Nuclear Medicine Mar 2024, 65 (3) 394-401; DOI: 10.2967/jnumed.123.266183

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Design, Preclinical Evaluation, and Clinical Translation of ⁶⁸Ga-FAPI-LM3, a Heterobivalent Molecule for PET Imaging of Nasopharyngeal Carcinoma

Liang Zhao, Yizhen Pang, Jianyang Fang, Jianhao Chen, Yangfan Zhou, Long Sun, Hua Wu, Zhide Guo, Qin Lin, Haojun Chen

Journal of Nuclear Medicine Mar 2024, 65 (3) 394-401; DOI: 10.2967/jnumed.123.266183

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Keywords

fibroblast activation protein
somatostatin receptor 2
heterobivalent molecule
nasopharyngeal carcinoma
PET

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Design, Preclinical Evaluation, and Clinical Translation of ⁶⁸Ga-FAPI-LM3, a Heterobivalent Molecule for PET Imaging of Nasopharyngeal Carcinoma

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