Preclinical Evaluation of 177Lu-OncoFAP-23, a Multivalent FAP-Targeted Radiopharmaceutical Therapeutic for Solid Tumors

Andrea Galbiati; Matilde Bocci; Domenico Ravazza; Jacqueline Mock; Ettore Gilardoni; Dario Neri; Samuele Cazzamalli

doi:10.2967/jnumed.124.268200

Research ArticleBasic Science Investigation

Preclinical Evaluation of ¹⁷⁷Lu-OncoFAP-23, a Multivalent FAP-Targeted Radiopharmaceutical Therapeutic for Solid Tumors

Andrea Galbiati, Matilde Bocci, Domenico Ravazza, Jacqueline Mock, Ettore Gilardoni, Dario Neri and Samuele Cazzamalli

Journal of Nuclear Medicine October 2024, 65 (10) 1604-1610; DOI: https://doi.org/10.2967/jnumed.124.268200

Andrea Galbiati

1R&D Department, Philochem AG, Otelfingen, Switzerland;

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Matilde Bocci

1R&D Department, Philochem AG, Otelfingen, Switzerland;

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Domenico Ravazza

1R&D Department, Philochem AG, Otelfingen, Switzerland;

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Jacqueline Mock

1R&D Department, Philochem AG, Otelfingen, Switzerland;

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Ettore Gilardoni

1R&D Department, Philochem AG, Otelfingen, Switzerland;

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Dario Neri

2Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, Zurich, Switzerland; and

3Philogen S.p.A., Siena, Italy

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Samuele Cazzamalli

1R&D Department, Philochem AG, Otelfingen, Switzerland;

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vol. 65 no. 10 1604-1610

DOI

https://doi.org/10.2967/jnumed.124.268200

PubMed

39266289

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Society of Nuclear Medicine

Print ISSN

0161-5505

Online ISSN

2159-662X

History

Received for publication June 7, 2024
Accepted for publication August 5, 2024
Published online October 1, 2024.

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previous version (September 12, 2024 - 08:33).
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Author Information

Andrea Galbiati¹,
Matilde Bocci¹,
Domenico Ravazza¹,
Jacqueline Mock¹,
Ettore Gilardoni¹,
Dario Neri²,³ and
Samuele Cazzamalli¹

¹R&D Department, Philochem AG, Otelfingen, Switzerland;
²Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, Zurich, Switzerland; and
³Philogen S.p.A., Siena, Italy

For correspondence or reprints, contact Andrea Galbiati (andrea.galbiati{at}philochem.ch) or Samuele Cazzamalli (samuele.cazzamalli{at}philochem.ch).

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Preclinical Evaluation of ¹⁷⁷Lu-OncoFAP-23, a Multivalent FAP-Targeted Radiopharmaceutical Therapeutic for Solid Tumors

Andrea Galbiati, Matilde Bocci, Domenico Ravazza, Jacqueline Mock, Ettore Gilardoni, Dario Neri, Samuele Cazzamalli

Journal of Nuclear Medicine Oct 2024, 65 (10) 1604-1610; DOI: 10.2967/jnumed.124.268200

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Preclinical Evaluation of ¹⁷⁷Lu-OncoFAP-23, a Multivalent FAP-Targeted Radiopharmaceutical Therapeutic for Solid Tumors

Andrea Galbiati, Matilde Bocci, Domenico Ravazza, Jacqueline Mock, Ettore Gilardoni, Dario Neri, Samuele Cazzamalli

Journal of Nuclear Medicine Oct 2024, 65 (10) 1604-1610; DOI: 10.2967/jnumed.124.268200

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Keywords

radiopharmaceuticals
fibroblast activation protein
OncoFAP
radiopharmaceutical therapeutics
targeted cancer therapy
tumor microenvironment

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Preclinical Evaluation of ¹⁷⁷Lu-OncoFAP-23, a Multivalent FAP-Targeted Radiopharmaceutical Therapeutic for Solid Tumors

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