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Research ArticleFEATURED BASIC SCIENCE ARTICLE

Preclinical Evaluation of Minigastrin Analogs and Proof-of-Concept [68Ga]Ga-DOTA-CCK-66 PET/CT in 2 Patients with Medullary Thyroid Cancer

Thomas Günther, Nadine Holzleitner, Oliver Viering, Roswitha Beck, Georgine Wienand, Alexander Dierks, Christian H. Pfob, Ralph A. Bundschuh, Malte Kircher, Constantin Lapa and Hans-Jürgen Wester
Journal of Nuclear Medicine January 2024, 65 (1) 33-39; DOI: https://doi.org/10.2967/jnumed.123.266537
Thomas Günther
1Department of Chemistry, Chair of Pharmaceutical Radiochemistry, TUM School of Natural Sciences, Technical University of Munich, Garching, Germany; and
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Nadine Holzleitner
1Department of Chemistry, Chair of Pharmaceutical Radiochemistry, TUM School of Natural Sciences, Technical University of Munich, Garching, Germany; and
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Oliver Viering
2Nuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany
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Roswitha Beck
1Department of Chemistry, Chair of Pharmaceutical Radiochemistry, TUM School of Natural Sciences, Technical University of Munich, Garching, Germany; and
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Georgine Wienand
2Nuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany
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Alexander Dierks
2Nuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany
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Christian H. Pfob
2Nuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany
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Ralph A. Bundschuh
2Nuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany
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Malte Kircher
2Nuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany
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Constantin Lapa
2Nuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany
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Hans-Jürgen Wester
1Department of Chemistry, Chair of Pharmaceutical Radiochemistry, TUM School of Natural Sciences, Technical University of Munich, Garching, Germany; and
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Article Information

vol. 65 no. 1 33-39
DOI 
https://doi.org/10.2967/jnumed.123.266537
PubMed 
37945383

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication August 11, 2023
  • Revision received October 19, 2023
  • Published online January 2, 2024.

Article Versions

  • previous version (November 9, 2023 - 11:21).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2024 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Thomas Günther*,1,
  2. Nadine Holzleitner*,1,
  3. Oliver Viering2,
  4. Roswitha Beck1,
  5. Georgine Wienand2,
  6. Alexander Dierks2,
  7. Christian H. Pfob2,
  8. Ralph A. Bundschuh2,
  9. Malte Kircher2,
  10. Constantin Lapa2 and
  11. Hans-Jürgen Wester1
  1. 1Department of Chemistry, Chair of Pharmaceutical Radiochemistry, TUM School of Natural Sciences, Technical University of Munich, Garching, Germany; and
  2. 2Nuclear Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany
  1. For correspondence or reprints, contact Thomas Günther (thomas.guenther{at}tum.de).
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  • Biodistribution and Radiation Dosimetry for 68Ga-DOTA-CCK-66, a Novel CCK2R-Targeting Compound for Imaging of Medullary Thyroid Cancer
    Oliver Viering, Andreas Rinscheid, Nadine Holzleitner, Alexander Dierks, Malte Kircher, Georgine Wienand, Marianne Patt, Hans-Jürgen Wester, Ralph A. Bundschuh, Thomas Günther, Constantin Lapa, Christian H. Pfob
    Clinical Nuclear Medicine 2024 49 12
  • Significant reduction of activity retention in the kidneys via optimized linker sequences in radiohybrid-based minigastrin analogs
    Nadine Holzleitner, Sebastian Fischer, Isabel Maniyankerikalam, Roswitha Beck, Constantin Lapa, Hans-Jürgen Wester, Thomas Günther
    EJNMMI Research 2024 14 1
  • CCK2Receptor Ligand [68Ga]Ga-DOTA-CCK-66 PET/CT Outperforms [68Ga]Ga-DOTATOC PET/CT in a Patient with Small Cell Lung Cancer
    Oliver Viering, Nadine Holzleitner, Rainer Claus, Adriana Amerein, Niklas Dreher, Johanna S. Enke, Alexander Dierks, Christian H. Pfob, Malte Kircher, Veronika Felber, Thomas Günther, Constantin Lapa
    Journal of Nuclear Medicine 2025 66 4
  • Medullary Thyroid Carcinoma
    Stefan Delorme, Friedhelm Raue, Bettina Beuthien-Baumann
    2025 223
  • Preclinical evaluation of 225Ac-labeled minigastrin analog DOTA-CCK-66 for Targeted Alpha Therapy
    Nadine Holzleitner, Meryl Vilangattil, Abir Swaidan, Clara Diaz Garcia-Prada, Marco F. Taddio, Pauline Jeanjean, Christine E. Mona, Constantin Lapa, Angela Casini, Thomas Günther, Giuseppe Carlucci
    European Journal of Nuclear Medicine and Molecular Imaging 2025 52 2

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Journal of Nuclear Medicine: 65 (1)
Journal of Nuclear Medicine
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January 1, 2024
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Preclinical Evaluation of Minigastrin Analogs and Proof-of-Concept [68Ga]Ga-DOTA-CCK-66 PET/CT in 2 Patients with Medullary Thyroid Cancer
Thomas Günther, Nadine Holzleitner, Oliver Viering, Roswitha Beck, Georgine Wienand, Alexander Dierks, Christian H. Pfob, Ralph A. Bundschuh, Malte Kircher, Constantin Lapa, Hans-Jürgen Wester
Journal of Nuclear Medicine Jan 2024, 65 (1) 33-39; DOI: 10.2967/jnumed.123.266537

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Preclinical Evaluation of Minigastrin Analogs and Proof-of-Concept [68Ga]Ga-DOTA-CCK-66 PET/CT in 2 Patients with Medullary Thyroid Cancer
Thomas Günther, Nadine Holzleitner, Oliver Viering, Roswitha Beck, Georgine Wienand, Alexander Dierks, Christian H. Pfob, Ralph A. Bundschuh, Malte Kircher, Constantin Lapa, Hans-Jürgen Wester
Journal of Nuclear Medicine Jan 2024, 65 (1) 33-39; DOI: 10.2967/jnumed.123.266537
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  • CCK2 Receptor Ligand [68Ga]Ga-DOTA-CCK-66 PET/CT Outperforms [68Ga]Ga-DOTATOC PET/CT in a Patient with Small Cell Lung Cancer
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Keywords

  • DOTA-CCK-66
  • clinical translation
  • CCK-2R
  • medullary thyroid cancer
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