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Research ArticleClinical Investigation

Diagnostic Accuracy of MR Spectroscopic Imaging and 18F-FET PET for Identifying Glioma: A Biopsy-Controlled Hybrid PET/MRI Study

Jörg Mauler, Philipp Lohmann, Andrew A. Maudsley, Sulaiman Sheriff, Moritz Hoevels, Anna-Katharina Meissner, Christina Hamisch, Anna Brunn, Martina Deckert, Christian P. Filss, Gabriele Stoffels, Jürgen Dammers, Maximillian I. Ruge, Norbert Galldiks, Felix M. Mottaghy, Karl-Josef Langen and N. Jon Shah
Journal of Nuclear Medicine January 2024, 65 (1) 16-21; DOI: https://doi.org/10.2967/jnumed.123.265868
Jörg Mauler
1Institute of Neuroscience and Medicine (INM-3/INM-4/INM-11), Forschungszentrum Juelich, Juelich, Germany;
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Philipp Lohmann
1Institute of Neuroscience and Medicine (INM-3/INM-4/INM-11), Forschungszentrum Juelich, Juelich, Germany;
2Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany;
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Andrew A. Maudsley
3Department of Radiology, Miller School of Medicine, University of Miami, Miami, Florida;
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Sulaiman Sheriff
3Department of Radiology, Miller School of Medicine, University of Miami, Miami, Florida;
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Moritz Hoevels
2Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany;
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Anna-Katharina Meissner
4Department of General Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany;
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Christina Hamisch
2Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany;
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Anna Brunn
5Institute of Neuropathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany;
6Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany;
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Martina Deckert
5Institute of Neuropathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany;
6Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany;
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Christian P. Filss
1Institute of Neuroscience and Medicine (INM-3/INM-4/INM-11), Forschungszentrum Juelich, Juelich, Germany;
7Department of Nuclear Medicine, RWTH Aachen University Hospital, Aachen, Germany;
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Gabriele Stoffels
1Institute of Neuroscience and Medicine (INM-3/INM-4/INM-11), Forschungszentrum Juelich, Juelich, Germany;
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Jürgen Dammers
1Institute of Neuroscience and Medicine (INM-3/INM-4/INM-11), Forschungszentrum Juelich, Juelich, Germany;
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Maximillian I. Ruge
2Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany;
8Center for Integrated Oncology, Universities of Aachen, Bonn, Cologne, and Duesseldorf, Germany;
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Norbert Galldiks
1Institute of Neuroscience and Medicine (INM-3/INM-4/INM-11), Forschungszentrum Juelich, Juelich, Germany;
8Center for Integrated Oncology, Universities of Aachen, Bonn, Cologne, and Duesseldorf, Germany;
9Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany;
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Felix M. Mottaghy
7Department of Nuclear Medicine, RWTH Aachen University Hospital, Aachen, Germany;
8Center for Integrated Oncology, Universities of Aachen, Bonn, Cologne, and Duesseldorf, Germany;
10Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands;
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Karl-Josef Langen
1Institute of Neuroscience and Medicine (INM-3/INM-4/INM-11), Forschungszentrum Juelich, Juelich, Germany;
7Department of Nuclear Medicine, RWTH Aachen University Hospital, Aachen, Germany;
8Center for Integrated Oncology, Universities of Aachen, Bonn, Cologne, and Duesseldorf, Germany;
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N. Jon Shah
1Institute of Neuroscience and Medicine (INM-3/INM-4/INM-11), Forschungszentrum Juelich, Juelich, Germany;
11Department of Neurology, RWTH Aachen University Hospital, Aachen, Germany; and
12JARA-BRAIN-Translational Medicine, Aachen, Germany
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Article Information

vol. 65 no. 1 16-21
DOI 
https://doi.org/10.2967/jnumed.123.265868
PubMed 
37884332

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication May 11, 2023
  • Revision received August 22, 2023
  • Published online January 2, 2024.

Article Versions

  • previous version (October 26, 2023 - 08:39).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2024 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Jörg Mauler1,
  2. Philipp Lohmann1,2,
  3. Andrew A. Maudsley3,
  4. Sulaiman Sheriff3,
  5. Moritz Hoevels2,
  6. Anna-Katharina Meissner4,
  7. Christina Hamisch2,
  8. Anna Brunn5,6,
  9. Martina Deckert5,6,
  10. Christian P. Filss1,7,
  11. Gabriele Stoffels1,
  12. Jürgen Dammers1,
  13. Maximillian I. Ruge2,8,
  14. Norbert Galldiks1,8,9,
  15. Felix M. Mottaghy7,8,10,
  16. Karl-Josef Langen1,7,8 and
  17. N. Jon Shah1,11,12
  1. 1Institute of Neuroscience and Medicine (INM-3/INM-4/INM-11), Forschungszentrum Juelich, Juelich, Germany;
  2. 2Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany;
  3. 3Department of Radiology, Miller School of Medicine, University of Miami, Miami, Florida;
  4. 4Department of General Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany;
  5. 5Institute of Neuropathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany;
  6. 6Institute of Neuropathology, University Hospital Düsseldorf and Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany;
  7. 7Department of Nuclear Medicine, RWTH Aachen University Hospital, Aachen, Germany;
  8. 8Center for Integrated Oncology, Universities of Aachen, Bonn, Cologne, and Duesseldorf, Germany;
  9. 9Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany;
  10. 10Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands;
  11. 11Department of Neurology, RWTH Aachen University Hospital, Aachen, Germany; and
  12. 12JARA-BRAIN-Translational Medicine, Aachen, Germany
  1. For correspondence or reprints, contact Jörg Mauler (j.mauler{at}fz-juelich.de).
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Diagnostic Accuracy of MR Spectroscopic Imaging and 18F-FET PET for Identifying Glioma: A Biopsy-Controlled Hybrid PET/MRI Study
Jörg Mauler, Philipp Lohmann, Andrew A. Maudsley, Sulaiman Sheriff, Moritz Hoevels, Anna-Katharina Meissner, Christina Hamisch, Anna Brunn, Martina Deckert, Christian P. Filss, Gabriele Stoffels, Jürgen Dammers, Maximillian I. Ruge, Norbert Galldiks, Felix M. Mottaghy, Karl-Josef Langen, N. Jon Shah
Journal of Nuclear Medicine Jan 2024, 65 (1) 16-21; DOI: 10.2967/jnumed.123.265868

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Diagnostic Accuracy of MR Spectroscopic Imaging and 18F-FET PET for Identifying Glioma: A Biopsy-Controlled Hybrid PET/MRI Study
Jörg Mauler, Philipp Lohmann, Andrew A. Maudsley, Sulaiman Sheriff, Moritz Hoevels, Anna-Katharina Meissner, Christina Hamisch, Anna Brunn, Martina Deckert, Christian P. Filss, Gabriele Stoffels, Jürgen Dammers, Maximillian I. Ruge, Norbert Galldiks, Felix M. Mottaghy, Karl-Josef Langen, N. Jon Shah
Journal of Nuclear Medicine Jan 2024, 65 (1) 16-21; DOI: 10.2967/jnumed.123.265868
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Keywords

  • MR spectroscopic imaging
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  • stereotactic biopsy
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