Development of FAPI Tetramers to Improve Tumor Uptake and Efficacy of FAPI Radioligand Therapy

Yizhen Pang; Liang Zhao; Jianyang Fang; Jianhao Chen; Lingxin Meng; Long Sun; Hua Wu; Zhide Guo; Qin Lin; Haojun Chen

doi:10.2967/jnumed.123.265599

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Development of FAPI Tetramers to Improve Tumor Uptake and Efficacy of FAPI Radioligand Therapy

Yizhen Pang, Liang Zhao, Jianyang Fang, Jianhao Chen, Lingxin Meng, Long Sun, Hua Wu, Zhide Guo, Qin Lin and Haojun Chen

Journal of Nuclear Medicine September 2023, 64 (9) 1449-1455; DOI: https://doi.org/10.2967/jnumed.123.265599

Yizhen Pang

1Department of Nuclear Medicine and Minnan PET Center, Xiamen Key Laboratory of Radiopharmaceuticals, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China;

2Department of Radiation Oncology, Xiamen Cancer Center, Xiamen Key Laboratory of Radiation Oncology, First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China;

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Liang Zhao

3Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore;

4Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; and

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Jianyang Fang

5State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China

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Jianhao Chen

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Lingxin Meng

5State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China

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Long Sun

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Hua Wu

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Zhide Guo

5State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China

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Qin Lin

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Haojun Chen

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Journal of Nuclear Medicine

Vol. 64, Issue 9

September 1, 2023

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Development of FAPI Tetramers to Improve Tumor Uptake and Efficacy of FAPI Radioligand Therapy

Yizhen Pang, Liang Zhao, Jianyang Fang, Jianhao Chen, Lingxin Meng, Long Sun, Hua Wu, Zhide Guo, Qin Lin, Haojun Chen

Journal of Nuclear Medicine Sep 2023, 64 (9) 1449-1455; DOI: 10.2967/jnumed.123.265599

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Development of FAPI Tetramers to Improve Tumor Uptake and Efficacy of FAPI Radioligand Therapy

Yizhen Pang, Liang Zhao, Jianyang Fang, Jianhao Chen, Lingxin Meng, Long Sun, Hua Wu, Zhide Guo, Qin Lin, Haojun Chen

Journal of Nuclear Medicine Sep 2023, 64 (9) 1449-1455; DOI: 10.2967/jnumed.123.265599

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Keywords

fibroblast activation protein
cancer-associated fibroblasts
tetramer
dimer
radioligand therapy

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