Article Figures & Data
Figures
- FIGURE 1.
Example of 68-y-old patient with PC. As part of hybrid imaging (PSMA PET/CT), body composition of CT was investigated. Sagittal (A), coronal (B), and axial (C–E) CT images show segmentation of separate tissue compartments at level of third and fourth lumbar vertebrae (L3–L4) applying different Hounsfield units: subcutaneous fat cross-sectional area (−190 to −30) (C), visceral fat cross-sectional area (−190 to −30) (D), and psoas muscle area (−29 to +150) (E).
- FIGURE 2.
Kaplan–Meier curves and log rank comparisons for patients with and without sarcopenia and treated with RLT, revealing no relevant differences in OS for men allocated to either group.
- FIGURE 3.
Kaplan–Meier curves and log rank comparisons for patients treated with RLT and stratified according to their BMI. Higher BMI was associated with longer median survival, in particular for obese subjects with BMI ≥ 30 kg/m2. *Compared with patients with BMI < 25 kg/m2.
Tables
Characteristic at initiation of RLT Data Age (y) 71 (46–95) PSA (ng/mL) 158 (0.07–5,000) CRP (mg/dL) 0.56 (0.02–29.34) LDH (U/L) 268 (118–1,800) Hemoglobin (g/dL) 11.6 (6.0–16.1) Interval between initial diagnosis and RLT (mo) 71 (9–364) Gleason score 9 (5–10) BMI (kg/m2) 25.8 (18.4–49.7) Normal (BMI < 25) 73 (42.7%) Preobese (25 ≤ BMI < 30) 56 (32.7%) Obese (BMI ≥ 30) 42 (24.6%) Body composition before initiation of RLT Psoas muscle area (cm2) 19.0 (7.9–37.2) PMI (cm2/m2) 6.1 (2.5–11.9) Sarcopenia (PMI < 5.7 cm2/m2) 65 (38.0%) Total fat area (cm2) 416.7 (104.8–1,372) Visceral fat area (cm2) 166.9 (23.3–478.9) Visceral fat index (cm2/m2) 53.8 (6.5–160.4) Subcutaneous fat area (cm2) 229.5 (70.2–1,053) Subcutaneous fat index (cm2/m2) 76.4 (22.8–307.6) Visceral fat–to–subcutaneous fat ratio 0.77 (0.25–1.96) Subcutaneous fat–to–muscle ratio 12.4 (3.7–42.5) RLT cycles (n) 2 (1–9) RLT in castration-resistant stage as… First-line therapy 6/171 (3.5%) Second-line therapy 25/171 (14.6%) Third-line therapy 71/171 (41.5%) Fourth-line therapy 60/171 (35.1%) Qualitative data are number and percentage; continuous data are median and range.
Parameter HR 95% CI AIC Harrell C P Null model 738.2 CRP (per mg/dL) 1.16 1.11–1.20 700.0 0.76 0.001 LDH (per 50 U/L) 1.16 1.11–1.20 703.2 0.75 0.001 Hemoglobin (per g/dL) 0.71 0.61–0.81 716.5 0.69 0.001 BMI (per kg/m2) 0.91 0.86–0.96 728.5 0.64 0.001 Interval between initial diagnosis and RLT (per year) 0.94 0.89–0.98 729.4 0.62 0.003 Weight (per kg) 0.97 0.96–0.99 731.5 0.63 0.005 PMI (cm2/m2) 0.85 0.75–0.97 733.8 0.59 0.01 Psoas muscle area (per cm2) 0.95 0.91–0.99 734.2 0.59 0.02 Total fat area (per 50 cm2) 0.93 0.88–0.99 735.3 0.57 0.03 Visceral fat area (per 50 cm2) 0.89 0.79–1.00 736.0 0.55 0.05 Visceral fat index (per cm2/m2) 0.99 0.99–1.00 736.1 0.56 0.05 PSA (per 50 ng/mL) 1.01 1.00–1.03 736.6 0.59 0.04 Subcutaneous fat index (per cm2/m2) 1.00 0.99–1.00 736.6 0.58 0.07 Subcutaneous fat area (per 50 cm2) 0.91 0.82–1.01 737.1 0.57 0.09 Sarcopenia present 1.39 0.90–2.12 738.0 0.55 0.14 Visceral fat–to–subcutaneous fat ratio 0.71 0.39–1.22 738.7 0.50 0.24 Age (per year) 0.99 0.96–1.01 739.2 0.54 0.31 Gleason score* 1.12 0.89–1.42 0.53 0.35 Subcutaneous fat–to–muscle ratio 0.99 0.96–1.03 740.1 0.51 0.74 ↵* Because of missing values, another null model was used and comparison was not possible.
AIC = Akaike information criterion.
Lower Akaike information criterion and higher Harrell C values indicate better-fit model (31,32).
Parameter HR 95% CI AIC Harrell C P Null model 738.2 CRP (per mg/dL) 1.09 1.03–1.14 675.8 0.80 <0.0001 LDH (per 50 U/L) 1.08 1.03–1.14 <0.001 BMI (per kg/m2) 0.91 0.86–0.97 0.006 Interval between initial diagnosis and RLT (per year) 0.95 0.91–0.99 0.02 Hemoglobin (per g/dL) 0.86 0.74–1.00 0.06 PMI (per cm2/m2) 0.92 0.80–1.01 0.25 PSA (per 50 ng/mL) 1.00 0.98–1.01 0.97 AIC = Akaike information criterion.
In this issue
Jump to section
Related Articles
Cited By...
- No citing articles found.