Superior Tumor Detection for 68Ga-FAPI-46 Versus 18F-FDG PET/CT and Conventional CT in Patients with Cholangiocarcinoma

Kim M. Pabst; Marija Trajkovic-Arsic; Phyllis F.Y. Cheung; Simone Ballke; Katja Steiger; Timo Bartel; Benedikt M. Schaarschmidt; Aleksandar Milosevic; Robert Seifert; Michael Nader; Lukas Kessler; Jens T. Siveke; Katharina Lueckerath; Stefan Kasper; Ken Herrmann; Nader Hirmas; Hartmut H. Schmidt; Rainer Hamacher; Wolfgang P. Fendler

doi:10.2967/jnumed.122.265215

Research ArticleClinical Investigation

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Superior Tumor Detection for ⁶⁸Ga-FAPI-46 Versus ¹⁸F-FDG PET/CT and Conventional CT in Patients with Cholangiocarcinoma

Kim M. Pabst, Marija Trajkovic-Arsic, Phyllis F.Y. Cheung, Simone Ballke, Katja Steiger, Timo Bartel, Benedikt M. Schaarschmidt, Aleksandar Milosevic, Robert Seifert, Michael Nader, Lukas Kessler, Jens T. Siveke, Katharina Lueckerath, Stefan Kasper, Ken Herrmann, Nader Hirmas, Hartmut H. Schmidt, Rainer Hamacher and Wolfgang P. Fendler

Journal of Nuclear Medicine July 2023, 64 (7) 1049-1055; DOI: https://doi.org/10.2967/jnumed.122.265215

Kim M. Pabst

1Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany;

2German Cancer Consortium, partner site University Hospital Essen, Essen, Germany;

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Marija Trajkovic-Arsic

2German Cancer Consortium, partner site University Hospital Essen, Essen, Germany;

3Division of Solid Tumor Translational Oncology, German Cancer Research Center, Heidelberg, Germany;

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Phyllis F.Y. Cheung

2German Cancer Consortium, partner site University Hospital Essen, Essen, Germany;

3Division of Solid Tumor Translational Oncology, German Cancer Research Center, Heidelberg, Germany;

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Simone Ballke

4Institute of Pathology, School of Medicine, Technical University of Munich, Munich, Germany;

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Katja Steiger

4Institute of Pathology, School of Medicine, Technical University of Munich, Munich, Germany;

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Timo Bartel

1Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany;

2German Cancer Consortium, partner site University Hospital Essen, Essen, Germany;

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Benedikt M. Schaarschmidt

5Department of Diagnostic and Interventional Radiology, University Hospital Essen, University of Duisburg–Essen, Essen Germany;

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Aleksandar Milosevic

5Department of Diagnostic and Interventional Radiology, University Hospital Essen, University of Duisburg–Essen, Essen Germany;

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Robert Seifert

1Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany;

2German Cancer Consortium, partner site University Hospital Essen, Essen, Germany;

6Department of Nuclear Medicine, University Hospital Münster, Münster, Germany;

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Michael Nader

1Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany;

2German Cancer Consortium, partner site University Hospital Essen, Essen, Germany;

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Lukas Kessler

1Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany;

2German Cancer Consortium, partner site University Hospital Essen, Essen, Germany;

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Jens T. Siveke

2German Cancer Consortium, partner site University Hospital Essen, Essen, Germany;

3Division of Solid Tumor Translational Oncology, German Cancer Research Center, Heidelberg, Germany;

7Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany;

8Bridge Institute of Experimental Tumor Therapy, West German Cancer Center, University Hospital Essen, Essen, Germany;

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Katharina Lueckerath

1Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany;

2German Cancer Consortium, partner site University Hospital Essen, Essen, Germany;

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Stefan Kasper

2German Cancer Consortium, partner site University Hospital Essen, Essen, Germany;

7Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany;

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Ken Herrmann

1Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany;

2German Cancer Consortium, partner site University Hospital Essen, Essen, Germany;

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Nader Hirmas

1Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany;

2German Cancer Consortium, partner site University Hospital Essen, Essen, Germany;

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Hartmut H. Schmidt

9Medical Clinic B, Department of Gastroenterology, Hepatology, Endocrinology, and Infectiology, University Hospital Münster, Münster, Germany; and

10Department of Gastroenterology and Hepatology, University Hospital Duisburg–Essen, Essen, Germany

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Rainer Hamacher

2German Cancer Consortium, partner site University Hospital Essen, Essen, Germany;

7Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany;

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Wolfgang P. Fendler

1Department of Nuclear Medicine, West German Cancer Center, University Hospital Essen, Essen, Germany;

2German Cancer Consortium, partner site University Hospital Essen, Essen, Germany;

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Superior Tumor Detection for ⁶⁸Ga-FAPI-46 Versus ¹⁸F-FDG PET/CT and Conventional CT in Patients with Cholangiocarcinoma

Journal of Nuclear Medicine Jul 2023, 64 (7) 1049-1055; DOI: 10.2967/jnumed.122.265215

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Superior Tumor Detection for ⁶⁸Ga-FAPI-46 Versus ¹⁸F-FDG PET/CT and Conventional CT in Patients with Cholangiocarcinoma

Journal of Nuclear Medicine Jul 2023, 64 (7) 1049-1055; DOI: 10.2967/jnumed.122.265215

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Keywords

68Ga-FAPI-46 PET/CT
18F-FDG PET/CT
conventional CT
cholangiocarcinoma
immunohistochemistry

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