Article Figures & Data
Figures
- FIGURE 1.
Interobserver agreement by primary tumor (T), local nodal involvement (N), distant metastasis (M), and experience level (high, intermediate, and low).
- FIGURE 2.
Example cases and lesions (arrows) with high agreement, high disagreement, and mixed agreement with SOR. Maximum intensity projections (MIPs) are represented above, and fused transaxial PET/CT images are represented below. (A) Patient with local relapse of urothelial cancer confirmed by histopathology; 7 readers rated positive (2 high, 3 intermediate, 2 low experience), and 8 readers rated lesion negative (3 high, 2 intermediate, 3 low experience). (B) Patient with ovarian cancer; all readers agreed with expert on peritoneal involvement. (C) All readers agreed with expert on liver metastasis in patient with colorectal carcinoma. (D) All readers correctly identified diverticulosis in sarcoma patient. (E) Patient with urothelial cancer and retroperitoneal fibrosis; all readers falsely rated retroperitoneal lesions as malignant and disagreed with expert panel and histopathology.
Tables
Characteristic Data Age (y) Mean 58 (SD, 16) Median 61 (range, 19, 83) Sex Female 23 (46.0%) Male 27 (54.0%) Indication Initial staging 21 (42.0%) Restaging 29 (58.0%) Tumor stage No tumor 8 (16.0%) Local 10 (20.0%) Local nodal metastatic 4 (8.0%) Metastatic (organ and bone) 28 (56.0%) Data are number followed by percentage in parentheses, except for age.
Category Agreement
levelMean κ Inferior
95% CISuperior
95% CIT High 0.709 0.705 0.710 Intermediate 0.729 0.727 0.732 Low 0.574 0.572 0.577 Any 0.563 0.490 0.633 N High 0.616 0.613 0.619 Intermediate 0.548 0.546 0.551 Low 0.513 0.510 0.516 Any 0.547 0.472 0.616 M High 0.749 0.746 0.752 Intermediate 0.647 0.645 0.650 Low 0.535 0.532 0.538 Any 0.686 0.614 0.757 - TABLE 3.
Sensitivity and Specificity for Observer with High, Intermediate, and Low Experience and for All Observers
Category Agreement
levelSE SP PPV NPV ACC T High 0.91 0.63 0.81 0.79 0.81 Intermediate 0.89 0.73 0.86 0.80 0.84 Low 0.88 0.59 0.79 0.73 0.77 All combined 0.89 0.65 0.82 0.77 0.81 N High 0.77 0.89 0.73 0.91 0.86 Intermediate 0.83 0.77 0.59 0.92 0.79 Low 0.88 0.59 0.79 0.73 0.77 All combined 0.79 0.81 0.61 0.91 0.80 M High 0.87 0.88 0.91 0.83 0.87 Intermediate 0.96 0.73 0.83 0.93 0.86 Low 0.90 0.70 0.80 0.83 0.81 All combined 0.91 0.77 0.84 0.86 0.85 SE = sensitivity; SP = specificity; PPV = positive predictive value; NPV = negative predictive value; ACC = accuracy.
- TABLE 4.
Overall Sensitivity and Specificity for Observer with High, Intermediate, or Low Experience
Experience level κ SE SP PPV NPV ACC High 0.69 0.87 0.82 0.83 0.86 0.85 Intermediate 0.66 0.91 0.75 0.79 0.89 0.83 Low 0.56 0.74 0.70 0.74 0.84 0.78 SE = sensitivity; SP = specificity; PPV = positive predictive value; NPV = negative predictive value; ACC = accuracy.
Tumor entity κ SE SP PPV NPV ACC Colorectal 0.68 0.84 0.85 0.83 0.86 0.85 Genitourinary 0.63 0.63 0.82 0.75 0.87 0.82 Miscellaneous 0.75 0.97 0.73 0.88 0.93 0.89 Pancreas 0.33 0.73 0.61 0.59 0.75 0.66 Sarcoma 0.74 0.96 0.77 0.83 0.95 0.87 SE = sensitivity; SP = specificity; PPV = positive predictive value; NPV = negative predictive value; ACC = accuracy.
Supplemental Data
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