A Realistic Multiregion Mouse Kidney Dosimetry Model to Support the Preclinical Evaluation of Potential Nephrotoxicity of Radiopharmaceutical Therapy

Clarita Saldarriaga Vargas; Lara Struelens; Matthias D’Huyvetter; Vicky Caveliers; Peter Covens

doi:10.2967/jnumed.122.264453

Research ArticleBasic Science Investigation

A Realistic Multiregion Mouse Kidney Dosimetry Model to Support the Preclinical Evaluation of Potential Nephrotoxicity of Radiopharmaceutical Therapy

Clarita Saldarriaga Vargas, Lara Struelens, Matthias D’Huyvetter, Vicky Caveliers and Peter Covens

Journal of Nuclear Medicine March 2023, 64 (3) 493-499; DOI: https://doi.org/10.2967/jnumed.122.264453

Clarita Saldarriaga Vargas

1Radiation Protection Dosimetry and Calibrations, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium; and

2Department of Medical Imaging, Laboratory for In Vivo Cellular and Molecular Imaging, Vrije Universiteit Brussel, Brussels, Belgium

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Lara Struelens

1Radiation Protection Dosimetry and Calibrations, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium; and

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Matthias D’Huyvetter

2Department of Medical Imaging, Laboratory for In Vivo Cellular and Molecular Imaging, Vrije Universiteit Brussel, Brussels, Belgium

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Vicky Caveliers

2Department of Medical Imaging, Laboratory for In Vivo Cellular and Molecular Imaging, Vrije Universiteit Brussel, Brussels, Belgium

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Peter Covens

2Department of Medical Imaging, Laboratory for In Vivo Cellular and Molecular Imaging, Vrije Universiteit Brussel, Brussels, Belgium

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Vol. 64, Issue 3

March 1, 2023

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A Realistic Multiregion Mouse Kidney Dosimetry Model to Support the Preclinical Evaluation of Potential Nephrotoxicity of Radiopharmaceutical Therapy

Clarita Saldarriaga Vargas, Lara Struelens, Matthias D’Huyvetter, Vicky Caveliers, Peter Covens

Journal of Nuclear Medicine Mar 2023, 64 (3) 493-499; DOI: 10.2967/jnumed.122.264453

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A Realistic Multiregion Mouse Kidney Dosimetry Model to Support the Preclinical Evaluation of Potential Nephrotoxicity of Radiopharmaceutical Therapy

Clarita Saldarriaga Vargas, Lara Struelens, Matthias D’Huyvetter, Vicky Caveliers, Peter Covens

Journal of Nuclear Medicine Mar 2023, 64 (3) 493-499; DOI: 10.2967/jnumed.122.264453

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Keywords

multiregion mouse kidney model
suborgan dosimetry
radiopharmaceutical therapy
MIRD
autoradiography

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