Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
Research ArticleClinical Investigation
Open Access

The Association of Age-Related and Off-Target Retention with Longitudinal Quantification of [18F]MK6240 Tau PET in Target Regions

Cécile Tissot, Stijn Servaes, Firoza Z. Lussier, João Pedro Ferrari-Souza, Joseph Therriault, Pâmela C.L. Ferreira, Gleb Bezgin, Bruna Bellaver, Douglas Teixeira Leffa, Sulantha S. Mathotaarachchi, Mira Chamoun, Jenna Stevenson, Nesrine Rahmouni, Min Su Kang, Vanessa Pallen, Nina Margherita-Poltronetti, Yi-Ting Wang, Jaime Fernandez-Arias, Andrea L. Benedet, Eduardo R. Zimmer, Jean-Paul Soucy, Dana L. Tudorascu, Annie D. Cohen, Madeleine Sharp, Serge Gauthier, Gassan Massarweh, Brian Lopresti, William E. Klunk, Suzanne L. Baker, Victor L. Villemagne, Pedro Rosa-Neto and Tharick A. Pascoal
Journal of Nuclear Medicine March 2023, 64 (3) 452-459; DOI: https://doi.org/10.2967/jnumed.122.264434
Cécile Tissot
1McGill University, Montreal, Quebec, Canada;
2McGill University Research Center for Studies in Aging, Montreal, Quebec, Canada;
3Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stijn Servaes
1McGill University, Montreal, Quebec, Canada;
2McGill University Research Center for Studies in Aging, Montreal, Quebec, Canada;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Firoza Z. Lussier
3Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
João Pedro Ferrari-Souza
3Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;
4Graduate Program in Biological Sciences: Biochemistry, Porto Alegre, Brazil;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joseph Therriault
1McGill University, Montreal, Quebec, Canada;
2McGill University Research Center for Studies in Aging, Montreal, Quebec, Canada;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pâmela C.L. Ferreira
3Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gleb Bezgin
1McGill University, Montreal, Quebec, Canada;
2McGill University Research Center for Studies in Aging, Montreal, Quebec, Canada;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bruna Bellaver
3Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;
4Graduate Program in Biological Sciences: Biochemistry, Porto Alegre, Brazil;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Douglas Teixeira Leffa
3Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sulantha S. Mathotaarachchi
1McGill University, Montreal, Quebec, Canada;
2McGill University Research Center for Studies in Aging, Montreal, Quebec, Canada;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mira Chamoun
1McGill University, Montreal, Quebec, Canada;
2McGill University Research Center for Studies in Aging, Montreal, Quebec, Canada;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jenna Stevenson
1McGill University, Montreal, Quebec, Canada;
2McGill University Research Center for Studies in Aging, Montreal, Quebec, Canada;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nesrine Rahmouni
1McGill University, Montreal, Quebec, Canada;
2McGill University Research Center for Studies in Aging, Montreal, Quebec, Canada;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Min Su Kang
5Artificial Intelligence and Computational Neurosciences Lab, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada;
6L.C. Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vanessa Pallen
1McGill University, Montreal, Quebec, Canada;
2McGill University Research Center for Studies in Aging, Montreal, Quebec, Canada;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nina Margherita-Poltronetti
1McGill University, Montreal, Quebec, Canada;
2McGill University Research Center for Studies in Aging, Montreal, Quebec, Canada;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yi-Ting Wang
1McGill University, Montreal, Quebec, Canada;
2McGill University Research Center for Studies in Aging, Montreal, Quebec, Canada;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jaime Fernandez-Arias
1McGill University, Montreal, Quebec, Canada;
2McGill University Research Center for Studies in Aging, Montreal, Quebec, Canada;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrea L. Benedet
7University of Gothenburg, Gothenburg, Sweden;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eduardo R. Zimmer
4Graduate Program in Biological Sciences: Biochemistry, Porto Alegre, Brazil;
8Department of Pharmacology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jean-Paul Soucy
9Montreal Neurological Institute, Montreal, Quebec, Canada;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dana L. Tudorascu
3Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Annie D. Cohen
3Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Madeleine Sharp
9Montreal Neurological Institute, Montreal, Quebec, Canada;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Serge Gauthier
2McGill University Research Center for Studies in Aging, Montreal, Quebec, Canada;
10Douglas Mental Health Institute, Montreal, Quebec, Canada;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gassan Massarweh
11Department of Radiochemistry, Montreal Neurological Institute, Montreal, Quebec, Canada;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Brian Lopresti
12Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
William E. Klunk
3Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Suzanne L. Baker
13Lawrence Berkeley National Laboratory, Berkeley, California
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Victor L. Villemagne
3Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pedro Rosa-Neto
1McGill University, Montreal, Quebec, Canada;
2McGill University Research Center for Studies in Aging, Montreal, Quebec, Canada;
9Montreal Neurological Institute, Montreal, Quebec, Canada;
10Douglas Mental Health Institute, Montreal, Quebec, Canada;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tharick A. Pascoal
3Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • PDF
Loading

Article Information

vol. 64 no. 3 452-459
DOI 
https://doi.org/10.2967/jnumed.122.264434
PubMed 
36396455

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication May 26, 2022
  • Revision received September 21, 2022
  • Published online March 2, 2023.

Article Versions

  • previous version (November 17, 2022 - 13:38).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2023 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

Author Information

  1. Cécile Tissot1,2,3,
  2. Stijn Servaes1,2,
  3. Firoza Z. Lussier3,
  4. João Pedro Ferrari-Souza3,4,
  5. Joseph Therriault1,2,
  6. Pâmela C.L. Ferreira3,
  7. Gleb Bezgin1,2,
  8. Bruna Bellaver3,4,
  9. Douglas Teixeira Leffa3,
  10. Sulantha S. Mathotaarachchi1,2,
  11. Mira Chamoun1,2,
  12. Jenna Stevenson1,2,
  13. Nesrine Rahmouni1,2,
  14. Min Su Kang5,6,
  15. Vanessa Pallen1,2,
  16. Nina Margherita-Poltronetti1,2,
  17. Yi-Ting Wang1,2,
  18. Jaime Fernandez-Arias1,2,
  19. Andrea L. Benedet7,
  20. Eduardo R. Zimmer4,8,
  21. Jean-Paul Soucy9,
  22. Dana L. Tudorascu3,
  23. Annie D. Cohen3,
  24. Madeleine Sharp9,
  25. Serge Gauthier2,10,
  26. Gassan Massarweh11,
  27. Brian Lopresti12,
  28. William E. Klunk3,
  29. Suzanne L. Baker13,
  30. Victor L. Villemagne3,
  31. Pedro Rosa-Neto1,2,9,10 and
  32. Tharick A. Pascoal3
  1. 1McGill University, Montreal, Quebec, Canada;
  2. 2McGill University Research Center for Studies in Aging, Montreal, Quebec, Canada;
  3. 3Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;
  4. 4Graduate Program in Biological Sciences: Biochemistry, Porto Alegre, Brazil;
  5. 5Artificial Intelligence and Computational Neurosciences Lab, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada;
  6. 6L.C. Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada;
  7. 7University of Gothenburg, Gothenburg, Sweden;
  8. 8Department of Pharmacology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;
  9. 9Montreal Neurological Institute, Montreal, Quebec, Canada;
  10. 10Douglas Mental Health Institute, Montreal, Quebec, Canada;
  11. 11Department of Radiochemistry, Montreal Neurological Institute, Montreal, Quebec, Canada;
  12. 12Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and
  13. 13Lawrence Berkeley National Laboratory, Berkeley, California
  1. For correspondence or reprints, contact Tharick Pascoal (pascoalt{at}upmc.edu).
View Full Text

Statistics from Altmetric.com

Cited By...

  • 6 Citations
  • 8 Citations
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Plasma and CSF concentrations of N‐terminal tau fragments associate with in vivo neurofibrillary tangle burden
    Juan Lantero‐Rodriguez, Cécile Tissot, Anniina Snellman, Stijn Servaes, Andrea L. Benedet, Nesrine Rahmouni, Laia Montoliu‐Gaya, Joseph Therriault, Wagner S. Brum, Jenna Stevenson, Firoza Z. Lussier, Gleb Bezgin, Arthur C. Macedo, Mira Chamoun, Sulantha S. Mathotaarachi, Tharick A. Pascoal, Nicholas J. Ashton, Henrik Zetterberg, Pedro Rosa Neto, Kaj Blennow
    Alzheimer's & Dementia 2023 19 12
  • APOE ε4 is associated with decreased synaptic density in cognitively impaired participants
    Kun He, Binyin Li, Jie Wang, Ying Wang, Zhiwen You, Xing Chen, Haijuan Chen, Junpeng Li, Qi Huang, Qihao Guo, Yiyun Henry Huang, Yihui Guan, Kewei Chen, Jun Zhao, Yulei Deng, Fang Xie
    Alzheimer's & Dementia 2024 20 5
  • Evaluating the effect of extra-cerebral off-target binding in [F-18]MK6240 PET scans in early-stage Alzheimer’s disease
    Andrew McVea, Alexandra DiFilippo, Max J. McLachlan, Matthew D. Zammit, Barbara Bendlin, Sterling C. Johnson, Tobey J. Betthauser, Bradley T. Christian
    Imaging Neuroscience 2024 2
  • Exploring the origins of frequent tau-PET signal in vermal and adjacent regions
    Agnes Kling, Julia Kusche-Palenga, Carla Palleis, Alexander Jäck, Alexander M. Bernhardt, Lukas Frontzkowski, Sebastian N. Roemer, Luna Slemann, Mirlind Zaganjori, Maximilian Scheifele, Lars Paeger, Gérard N. Bischof, Thilo van Eimeren, Alexander Drzezga, Osama Sabri, Michael Rullmann, Henryk Barthel, Johannes Levin, Jochen Herms, Nicolai Franzmeier, Günter Höglinger, Sigrun Roeber, Matthias Brendel, Johannes Gnörich
    European Journal of Nuclear Medicine and Molecular Imaging 2025
  • Increased between-network connectivity: A risk factor for tau elevation and disease progression
    Seyed Hani Hojjati, Tracy A. Butler, José A. Luchsinger, Richard Benitez, Mony de Leon, Siddharth Nayak, Qolamreza R. Razlighi, Gloria C. Chiang
    Neuroscience Letters 2024 840
  • Structure–Activity Relationships and Evaluation of 2-(Heteroaryl-cycloalkyl)-1H-indoles as Tauopathy Positron Emission Tomography Radiotracers
    Jeffrey S. Stehouwer, Guofeng Huang, Dinahlee Saturnino Guarino, Manik L. Debnath, Ashok Polu, Steven J. Geib, Brian Lopresti, Milos D. Ikonomovic, Neale Mason, Robert H. Mach, Chester A. Mathis
    Journal of Medicinal Chemistry 2025 68 6
  • Test–retest performance of [18F]MK-6240 tau burden and relative delivery indices in cognitively normal older subjects using PET/MRI
    Cristina Lois, Jessie Fanglu Fu, Andrew N. Salvatore, Arun H. Garimella, Derek Huell, Hasan Sari, David Izquierdo Garcia, Nathaniel D. Mercaldo, Bradford Dickerson, Keith A. Johnson, Ciprian Catana, Julie C. Price
    Imaging Neuroscience 2024 2
  • Transmembrane protein 106B amyloid is a potential off-target molecule of tau PET tracers in the choroid plexus
    Yuka Yokoyama, Ryuichi Harada, Kaede Kudo, Ren Iwata, Yukitsuka Kudo, Nobuyuki Okamura, Shozo Furumoto
    Nuclear Medicine and Biology 2025 142-143

Article usage

Article usage: November 2022 to April 2025

AbstractFullPdf
Nov 202218940166
Dec 2022475068
Jan 2023295048
Feb 2023191035
Mar 202344054489
Apr 202312735670
May 20238724956
Jun 20235325742
Jul 20236621223
Aug 20235135628
Sep 20232825932
Oct 20233516922
Nov 20233013422
Dec 2023306624
Jan 20245011237
Feb 20243018737
Mar 20243114848
Apr 20245763101
May 2024423922
Jun 2024516015
Jul 202410710243
Aug 20249810335
Sep 2024174425
Oct 2024243530
Nov 2024323416
Dec 2024313916
Jan 2025243433
Feb 2025489041
Mar 2025285435
Apr 2025274753
PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine: 64 (3)
Journal of Nuclear Medicine
Vol. 64, Issue 3
March 1, 2023
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Complete Issue (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The Association of Age-Related and Off-Target Retention with Longitudinal Quantification of [18F]MK6240 Tau PET in Target Regions
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
The Association of Age-Related and Off-Target Retention with Longitudinal Quantification of [18F]MK6240 Tau PET in Target Regions
Cécile Tissot, Stijn Servaes, Firoza Z. Lussier, João Pedro Ferrari-Souza, Joseph Therriault, Pâmela C.L. Ferreira, Gleb Bezgin, Bruna Bellaver, Douglas Teixeira Leffa, Sulantha S. Mathotaarachchi, Mira Chamoun, Jenna Stevenson, Nesrine Rahmouni, Min Su Kang, Vanessa Pallen, Nina Margherita-Poltronetti, Yi-Ting Wang, Jaime Fernandez-Arias, Andrea L. Benedet, Eduardo R. Zimmer, Jean-Paul Soucy, Dana L. Tudorascu, Annie D. Cohen, Madeleine Sharp, Serge Gauthier, Gassan Massarweh, Brian Lopresti, William E. Klunk, Suzanne L. Baker, Victor L. Villemagne, Pedro Rosa-Neto, Tharick A. Pascoal
Journal of Nuclear Medicine Mar 2023, 64 (3) 452-459; DOI: 10.2967/jnumed.122.264434

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
The Association of Age-Related and Off-Target Retention with Longitudinal Quantification of [18F]MK6240 Tau PET in Target Regions
Cécile Tissot, Stijn Servaes, Firoza Z. Lussier, João Pedro Ferrari-Souza, Joseph Therriault, Pâmela C.L. Ferreira, Gleb Bezgin, Bruna Bellaver, Douglas Teixeira Leffa, Sulantha S. Mathotaarachchi, Mira Chamoun, Jenna Stevenson, Nesrine Rahmouni, Min Su Kang, Vanessa Pallen, Nina Margherita-Poltronetti, Yi-Ting Wang, Jaime Fernandez-Arias, Andrea L. Benedet, Eduardo R. Zimmer, Jean-Paul Soucy, Dana L. Tudorascu, Annie D. Cohen, Madeleine Sharp, Serge Gauthier, Gassan Massarweh, Brian Lopresti, William E. Klunk, Suzanne L. Baker, Victor L. Villemagne, Pedro Rosa-Neto, Tharick A. Pascoal
Journal of Nuclear Medicine Mar 2023, 64 (3) 452-459; DOI: 10.2967/jnumed.122.264434
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSION
    • DISCLOSURE
    • ACKNOWLEDGMENT
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • 177Lu-PSMA-617 Consolidation Therapy After Docetaxel in Patients with Synchronous High-Volume Metastatic Hormone-Sensitive Prostate Cancer: A Randomized, Phase 2 Trial
  • Transarterial Radioembolization in the TACOME Trial: Dosimetric Analysis and Clinical Features in Predicting Response and Overall Survival
  • Retreatment of Metastatic Castration-Resistant Prostate Cancer Patients with 223Ra Therapy in Daily Practice
Show more Clinical Investigation

Similar Articles

Keywords

  • tau
  • PET
  • reference region
  • off-target binding
  • [18F]MK6240
SNMMI

© 2025 SNMMI

Powered by HighWire