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Research ArticleBasic Science Investigation

Performance Characteristics of a New-Generation Digital Bismuth Germanium Oxide PET/CT System, Omni Legend 32, According to NEMA NU 2-2018 Standards

Shin Yamagishi, Kenta Miwa, Shun Kamitaki, Kouichi Anraku, Shun Sato, Tensho Yamao, Hitoshi Kubo, Noriaki Miyaji and Kazuhiro Oguchi
Journal of Nuclear Medicine December 2023, 64 (12) 1990-1997; DOI: https://doi.org/10.2967/jnumed.123.266140
Shin Yamagishi
1Center of Radiology and Diagnostic Imaging, Aizawa Hospital, Nagano, Japan; and
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Kenta Miwa
2Department of Radiological Sciences, School of Health Sciences, Fukushima Medical University, Fukushima, Japan
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Shun Kamitaki
1Center of Radiology and Diagnostic Imaging, Aizawa Hospital, Nagano, Japan; and
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Kouichi Anraku
1Center of Radiology and Diagnostic Imaging, Aizawa Hospital, Nagano, Japan; and
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Shun Sato
1Center of Radiology and Diagnostic Imaging, Aizawa Hospital, Nagano, Japan; and
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Tensho Yamao
2Department of Radiological Sciences, School of Health Sciences, Fukushima Medical University, Fukushima, Japan
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Hitoshi Kubo
2Department of Radiological Sciences, School of Health Sciences, Fukushima Medical University, Fukushima, Japan
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Noriaki Miyaji
2Department of Radiological Sciences, School of Health Sciences, Fukushima Medical University, Fukushima, Japan
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Kazuhiro Oguchi
1Center of Radiology and Diagnostic Imaging, Aizawa Hospital, Nagano, Japan; and
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  • FIGURE 1.
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    FIGURE 1.

    Sensitivity values at 0- and 10-cm offset. (A) Sensitivity as function of numbers of attenuating aluminum sleeves. (B) Axial sensitivity profile.

  • FIGURE 2.
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    FIGURE 2.

    Count rates for prompt, random, true, and scatter events and noise-equivalent count (NEC) as function of activity concentration.

  • FIGURE 3.
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    FIGURE 3.

    Scatter fraction for Omni Legend as function of activity concentration.

  • FIGURE 4.
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    FIGURE 4.

    Accuracy of extrapolated true rate (A) and maximum, mean, and minimum error (B) as function of activity concentration for Omni Legend.

  • FIGURE 5.
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    FIGURE 5.

    Images of deluxe (A) and mini deluxe (B) Derenzo phantoms using Q.Clear (β-value, 50): original distribution of CT images (left) and actual acquired PET images (right).

  • FIGURE 6.
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    FIGURE 6.

    Pancreatic cancer patient images acquired using Omni Legend at 120 s/bed position (8 min total). (A) Maximum-intensity-projection PET images. Numbers indicate lesion SUVmax. (B) Transaxial PET images. HPDL = high-precision DL; LPDL = low precision DL; MPDL = medium-precision DL; noise = noise level of liver (%); non-PDL = nonprecision DL; PSF = point-spread function.

  • FIGURE 7.
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    FIGURE 7.

    Lung cancer patient images acquired using Omni Legend at 120 s/bed position (8 min total). (A) Maximum-intensity-projection PET images. Numbers indicate lesion SUVmax. (B) Coronal PET images. HPDL = high-precision DL; LPDL = low precision DL; MPDL = medium-precision DL; noise = noise level of liver (%); non-PDL = nonprecision DL; PSF = point-spread function.

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    TABLE 1.

    All NEMA NU 2-2018 Results for Omni Legend

    ParameterValue
    Spatial resolution (FWHM, mm)
     FBP
      1 cm4.34, radial; 4.22, tangential; 4.42, axial
      10 cm5.90, radial; 4.55, tangential; 5.57, axial
      20 cm7.83, radial; 5.03, tangential; 5.59, axial
     OSEM
      1 cm3.89, radial; 3.73, tangential; 3.61, axial
      10 cm5.10, radial; 3.90, tangential; 3.76, axial
      20 cm7.59, radial; 4.26, tangential; 3.58, axial
    Sensitivity (cps/kBq)
     At center47.30
     At 10 cm47.05
    Count rate statistics
     Peak NECR (kcps)501.7
     Peak NECR activity (kBq/mL)15.70
     Scatter fraction at peak NECR (%)35.42
     Maximum error at peak NECR (%)1.70
     Maximum mean error at peak NECR (%)0.98
    Image quality (%)
     OSEM
      10 mm53.5 (3.1), CR; 8.0 (0.8), BV
      13 mm65.1 (2.2), CR; 6.5 (0.9), BV
      17 mm73.0 (2.8), CR; 5.0 (0.6), BV
      22 mm78.5 (2.4), CR; 3.9 (0.3), BV
      28 mm85.3 (2.7), CR; 3.2 (0.3), BV
      37 mm88.9 (2.3), CR; 2.6 (0.1), BV
      Average lung error12.0 (0.3)
     Q.Clear (β-value, 50)
      10 mm61.3 (3.3), CR; 5.4(0.8), BV
      13 mm75.2 (1.6), CR; 4.2(0.4), BV
      17 mm80.1 (1.3), CR; 3.3(0.3), BV
      22 mm84.5 (1.2), CR; 2.7(0.3), BV
      28 mm90.1 (1.2), CR; 2.2(0.3), BV
      37 mm93.0 (1.2), CR; 1.7(0.1), BV
      Average lung error5.1 (0.3)
     Q.Clear (β-value, 300)
      10 mm36.4 (2.1), CR; 2.9(0.5), BV
      13 mm60.5 (0.5), CR; 2.5(0.4), BV
      17 mm71.6 (0.6), CR; 2.1(0.3), BV
      22 mm79.3 (0.8), CR; 1.8(0.3), BV
      28 mm85.1 (0.6), CR; 1.5(0.2), BV
      37 mm89.7 (0.3), CR; 1.3(0.1), BV
      Average lung error6.3 (0.2)
    Coregistration accuracy (mm)
     Error at (0,1)0.85, 5 cm; 2.47, 100 cm
     Error at (0,20)1.54, 5 cm; 3.30, 100 cm
     Error at (20,0)1.29, 5 cm; 2.73, 100 cm
    • FWHM = full width at half maximum; FBP = filtered backprojection; CR = contrast recovery; BV = background variability.

    • Data in parentheses are SDs.

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Journal of Nuclear Medicine: 64 (12)
Journal of Nuclear Medicine
Vol. 64, Issue 12
December 1, 2023
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Performance Characteristics of a New-Generation Digital Bismuth Germanium Oxide PET/CT System, Omni Legend 32, According to NEMA NU 2-2018 Standards
Shin Yamagishi, Kenta Miwa, Shun Kamitaki, Kouichi Anraku, Shun Sato, Tensho Yamao, Hitoshi Kubo, Noriaki Miyaji, Kazuhiro Oguchi
Journal of Nuclear Medicine Dec 2023, 64 (12) 1990-1997; DOI: 10.2967/jnumed.123.266140

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Performance Characteristics of a New-Generation Digital Bismuth Germanium Oxide PET/CT System, Omni Legend 32, According to NEMA NU 2-2018 Standards
Shin Yamagishi, Kenta Miwa, Shun Kamitaki, Kouichi Anraku, Shun Sato, Tensho Yamao, Hitoshi Kubo, Noriaki Miyaji, Kazuhiro Oguchi
Journal of Nuclear Medicine Dec 2023, 64 (12) 1990-1997; DOI: 10.2967/jnumed.123.266140
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Keywords

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