Preclinical Evaluation of a Radiotheranostic Single-Domain Antibody Against Fibroblast Activation Protein α

Yana Dekempeneer; Sam Massa; Francis Santens; Laurent Navarro; Marion Berdal; Melissa Miranda Lucero; Ana Rita Pombo Antunes; Tony Lahoutte; Jo A. Van Ginderachter; Nick Devoogdt; Matthias D’Huyvetter

doi:10.2967/jnumed.123.266381

Research ArticleBasic Science Investigation

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Preclinical Evaluation of a Radiotheranostic Single-Domain Antibody Against Fibroblast Activation Protein α

Yana Dekempeneer, Sam Massa, Francis Santens, Laurent Navarro, Marion Berdal, Melissa Miranda Lucero, Ana Rita Pombo Antunes, Tony Lahoutte, Jo A. Van Ginderachter, Nick Devoogdt and Matthias D’Huyvetter

Journal of Nuclear Medicine December 2023, 64 (12) 1941-1948; DOI: https://doi.org/10.2967/jnumed.123.266381

Yana Dekempeneer

1Precirix NV/SA, Brussels, Belgium;

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Sam Massa

1Precirix NV/SA, Brussels, Belgium;

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Francis Santens

1Precirix NV/SA, Brussels, Belgium;

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Laurent Navarro

1Precirix NV/SA, Brussels, Belgium;

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Marion Berdal

1Precirix NV/SA, Brussels, Belgium;

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Melissa Miranda Lucero

1Precirix NV/SA, Brussels, Belgium;

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Ana Rita Pombo Antunes

1Precirix NV/SA, Brussels, Belgium;

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Tony Lahoutte

1Precirix NV/SA, Brussels, Belgium;

2Department of Medical Imaging, In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium;

3Department of Nuclear Medicine, UZ Brussel, Brussels, Belgium;

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Jo A. Van Ginderachter

4Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium; and

5Myeloid Cell Immunology Lab, VIB Center for Inflammation Research, Brussels, Belgium

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Nick Devoogdt

1Precirix NV/SA, Brussels, Belgium;

2Department of Medical Imaging, In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium;

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Matthias D’Huyvetter

1Precirix NV/SA, Brussels, Belgium;

2Department of Medical Imaging, In Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, Brussels, Belgium;

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Journal of Nuclear Medicine

Vol. 64, Issue 12

December 1, 2023

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Preclinical Evaluation of a Radiotheranostic Single-Domain Antibody Against Fibroblast Activation Protein α

Journal of Nuclear Medicine Dec 2023, 64 (12) 1941-1948; DOI: 10.2967/jnumed.123.266381

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Preclinical Evaluation of a Radiotheranostic Single-Domain Antibody Against Fibroblast Activation Protein α

Journal of Nuclear Medicine Dec 2023, 64 (12) 1941-1948; DOI: 10.2967/jnumed.123.266381

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Keywords

fibroblast activation protein α
single-domain antibodies
radiotheranostics
targeted radionuclide therapy

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