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Research ArticleBasic Science Investigation
Open Access

Tumor Control Probability and Small-Scale Monte Carlo Dosimetry: Effects of Heterogenous Intratumoral Activity Distribution in Radiopharmaceutical Therapy

Emma Mellhammar, Magnus Dahlbom, Oskar Vilhelmsson-Timmermand and Sven-Erik Strand
Journal of Nuclear Medicine October 2023, 64 (10) 1632-1637; DOI: https://doi.org/10.2967/jnumed.123.265523
Emma Mellhammar
1Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden;
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Magnus Dahlbom
2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California;
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Oskar Vilhelmsson-Timmermand
1Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden;
3Imaging Chemistry and Biology, King’s College London, London, United Kingdom; and
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Sven-Erik Strand
1Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden;
4Medical Radiation Physics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
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Article Information

vol. 64 no. 10 1632-1637
DOI 
https://doi.org/10.2967/jnumed.123.265523
PubMed 
37934033

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication January 30, 2023
  • Revision received June 12, 2023
  • Published online October 3, 2023.

Article Versions

  • previous version (July 27, 2023 - 07:14).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2023 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

Author Information

  1. Emma Mellhammar1,
  2. Magnus Dahlbom2,
  3. Oskar Vilhelmsson-Timmermand1,3 and
  4. Sven-Erik Strand1,4
  1. 1Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden;
  2. 2Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California;
  3. 3Imaging Chemistry and Biology, King’s College London, London, United Kingdom; and
  4. 4Medical Radiation Physics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
  1. For correspondence or reprints, contact Emma Mellhammar (emma.mellhammar{at}med.lu.se).
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Journal of Nuclear Medicine: 64 (10)
Journal of Nuclear Medicine
Vol. 64, Issue 10
October 1, 2023
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Tumor Control Probability and Small-Scale Monte Carlo Dosimetry: Effects of Heterogenous Intratumoral Activity Distribution in Radiopharmaceutical Therapy
Emma Mellhammar, Magnus Dahlbom, Oskar Vilhelmsson-Timmermand, Sven-Erik Strand
Journal of Nuclear Medicine Oct 2023, 64 (10) 1632-1637; DOI: 10.2967/jnumed.123.265523

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Tumor Control Probability and Small-Scale Monte Carlo Dosimetry: Effects of Heterogenous Intratumoral Activity Distribution in Radiopharmaceutical Therapy
Emma Mellhammar, Magnus Dahlbom, Oskar Vilhelmsson-Timmermand, Sven-Erik Strand
Journal of Nuclear Medicine Oct 2023, 64 (10) 1632-1637; DOI: 10.2967/jnumed.123.265523
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Keywords

  • Monte Carlo dosimetry simulation
  • radiopharmaceutical therapy
  • digital autoradiography
  • tumor control probability
  • heterogeneity
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