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Research ArticleEditorial

Is Actinium Really Happening?

Richard Zimmermann
Journal of Nuclear Medicine October 2023, 64 (10) 1516-1518; DOI: https://doi.org/10.2967/jnumed.123.265907
Richard Zimmermann
Chrysalium Consulting, Lalaye, France; MEDraysintell, Louvain-la-Neuve, Belgium; and Oncidium Foundation, Mont-Saint-Guibert, Belgium
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    TABLE 1.

    Technologies Under Development and Operating Sites for 225Ac Production, Including Estimated Present and 2032 Capacities

    Yearly production capacity (GBq/y/site)Comment
    TechnologySource20232032Total (GBq/y) in 2032
    A: [(233U→) 229Th→225Ac] (generator)ORNL, United States2626Up to 3,000 [80]Highest quality of nca 225Ac; may enter price competitivity
    IPPE, Russia37 (est.)150 (est. 2025) to 300 (est. 2030)
    JRC-ITU, Germany1111
    TRIUMF, Canada0.40.4
    TerraPower, United States>10≤2,700
    Pantera, Belgium0>70TerraPower source
    B: [232Th(p,x)225Ac+227Ac] (high-energy accelerator)BNL/ORNL LANL; Tri-Lab, United States16.7Potential, >3,700>9,000 [>240]Contaminated with 227Ac (0.2% EOB - ∼1.5% at calibration); not suitable for large scale routine use
    CNL/TRIUMF, Canada; BWXT/ITM, United States/Germany>1Idem >3,700
    INR, Russia≤1,000
    SpectronRx, United States>1>200
    Others: Arronax, France; IsoDar, Japan; CIAE, ChinaFirst GBq in 2024Potential, >200 each
    C: [+…+225Ra→225Ac] (as side product)∼10% of above; CNL/TRIUMF, Canada0.3>370 (theory)>370 [>10]High level of waste - expensive
    D: [226Ra(p,2n)225Ac] (cyclotron)First GBq>4,500 [>120]Additional sites under evaluation in other countries (Asia)
    SpectronRx, United States2023>500
    Ionetix, United States20231,900
    Eckert&Ziegler, Germany2024550
    Alfarim, Netherlands2025450–850
    N-MediPhysics, Japan>2023>500
    KIRAMS, South Korea>2025>500
    D: [226Ra(d,3n)225Ac] (linear accelerator)Nusano, United States≤160,000Under evaluation
    E: [226Ra(γ,n)225Ra→225Ac] (photoconverter)NorthStar, United States20233,700–15,000>37,000 [>1,000]Rhodotron: nca 225Ac
    Pantera, Belgium20273,700–5,000
    TerraPower, United States20293,700–5,000
    Niowave, United States2023≤18,000Linac: nca 225Ac
    Hitachi, Japan>2024>3,700
    F: [226Ra(n,2n)225Ra→225Ac] (n from d on beryllium target)Nusano, United States≤44,000Under evaluation
    • ORNL = Oak Ridge National Laboratory; nca = no carrier added; IPPE = I.I. Leypunsky Institute of Physics and Power Engineering, Obninsk; est. = estimated; JRC-ITE = Joint Research Centre–Institute for Transuranium Elements; TRIUMF = TRI University Meson Facility; BNL = Brookhaven National Laboratory; LANL = Los Alamos National Laboratory; EOB = end of bombardment; CNL = Canadian Nuclear Laboratories; BWXT = BWX Technologies Inc.; ITM = Isotope Technologies Munich SE; INR = Institute for Nuclear Research of the Russian Academy of Science; CIAE = China Institute of Atomic Energy; KIRAMS = Korea Institute of Radiological and Medical Sciences.

    • Data in brackets are curies.

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Journal of Nuclear Medicine: 64 (10)
Journal of Nuclear Medicine
Vol. 64, Issue 10
October 1, 2023
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Is Actinium Really Happening?
Richard Zimmermann
Journal of Nuclear Medicine Oct 2023, 64 (10) 1516-1518; DOI: 10.2967/jnumed.123.265907

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Is Actinium Really Happening?
Richard Zimmermann
Journal of Nuclear Medicine Oct 2023, 64 (10) 1516-1518; DOI: 10.2967/jnumed.123.265907
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