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Research ArticleFEATURED BASIC SCIENCE ARTICLE
Open Access

Antigen-Dependent Inducible T-Cell Reporter System for PET Imaging of Breast Cancer and Glioblastoma

Jaehoon Shin, Matthew F.L. Parker, Iowis Zhu, Aryn Alanizi, Carlos I. Rodriguez, Raymond Liu, Payal B. Watchmaker, Mausam Kalita, Joseph Blecha, Justin Luu, Brian Wright, Suzanne E. Lapi, Robert R. Flavell, Hideho Okada, Thea D. Tlsty, Kole T. Roybal and David M. Wilson
Journal of Nuclear Medicine January 2023, 64 (1) 137-144; DOI: https://doi.org/10.2967/jnumed.122.264284
Jaehoon Shin
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
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Matthew F.L. Parker
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
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Iowis Zhu
2Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California;
3Parker Institute for Cancer Immunotherapy, San Francisco, California;
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Aryn Alanizi
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
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Carlos I. Rodriguez
4Department of Pathology, University of California, San Francisco, San Francisco, California;
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Raymond Liu
2Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California;
3Parker Institute for Cancer Immunotherapy, San Francisco, California;
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Payal B. Watchmaker
5Department of Neurological Surgery, University of California, San Francisco, San Francisco, California;
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Mausam Kalita
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
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Joseph Blecha
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
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Justin Luu
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
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Brian Wright
6Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama;
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Suzanne E. Lapi
6Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama;
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Robert R. Flavell
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
7Helen Diller Cancer Center, University of California, San Francisco, San Francisco, California;
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Hideho Okada
3Parker Institute for Cancer Immunotherapy, San Francisco, California;
5Department of Neurological Surgery, University of California, San Francisco, San Francisco, California;
7Helen Diller Cancer Center, University of California, San Francisco, San Francisco, California;
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Thea D. Tlsty
4Department of Pathology, University of California, San Francisco, San Francisco, California;
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Kole T. Roybal
2Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California;
3Parker Institute for Cancer Immunotherapy, San Francisco, California;
7Helen Diller Cancer Center, University of California, San Francisco, San Francisco, California;
8Chan Zuckerberg Biohub, San Francisco, California;
9Gladstone UCSF Institute for Genetic Immunology, San Francisco, California; and
10UCSF Cell Design Institute, San Francisco, California
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David M. Wilson
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
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Article Information

vol. 64 no. 1 137-144
DOI 
https://doi.org/10.2967/jnumed.122.264284
PubMed 
35981900

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication April 23, 2022
  • Revision received June 29, 2022
  • Published online January 4, 2023.

Article Versions

  • previous version (August 18, 2022 - 12:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2023 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

Author Information

  1. Jaehoon Shin*,1,
  2. Matthew F.L. Parker*,1,
  3. Iowis Zhu*,2,3,
  4. Aryn Alanizi1,
  5. Carlos I. Rodriguez4,
  6. Raymond Liu2,3,
  7. Payal B. Watchmaker5,
  8. Mausam Kalita1,
  9. Joseph Blecha1,
  10. Justin Luu1,
  11. Brian Wright6,
  12. Suzanne E. Lapi6,
  13. Robert R. Flavell1,7,
  14. Hideho Okada3,5,7,
  15. Thea D. Tlsty4,
  16. Kole T. Roybal2,3,7,8,9,10 and
  17. David M. Wilson1
  1. 1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California;
  2. 2Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California;
  3. 3Parker Institute for Cancer Immunotherapy, San Francisco, California;
  4. 4Department of Pathology, University of California, San Francisco, San Francisco, California;
  5. 5Department of Neurological Surgery, University of California, San Francisco, San Francisco, California;
  6. 6Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama;
  7. 7Helen Diller Cancer Center, University of California, San Francisco, San Francisco, California;
  8. 8Chan Zuckerberg Biohub, San Francisco, California;
  9. 9Gladstone UCSF Institute for Genetic Immunology, San Francisco, California; and
  10. 10UCSF Cell Design Institute, San Francisco, California
  1. For correspondence or reprints, contact corresponding authors David M. Wilson (david.m.wilson{at}ucsf.edu), Kole T. Roybal (kole.roybal{at}ucsf.edu), or Thea D. Tlsty (thea.tlsty{at}ucsf.edu).
  1. ↵* Contributed equally to this work.

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Journal of Nuclear Medicine: 64 (1)
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Antigen-Dependent Inducible T-Cell Reporter System for PET Imaging of Breast Cancer and Glioblastoma
Jaehoon Shin, Matthew F.L. Parker, Iowis Zhu, Aryn Alanizi, Carlos I. Rodriguez, Raymond Liu, Payal B. Watchmaker, Mausam Kalita, Joseph Blecha, Justin Luu, Brian Wright, Suzanne E. Lapi, Robert R. Flavell, Hideho Okada, Thea D. Tlsty, Kole T. Roybal, David M. Wilson
Journal of Nuclear Medicine Jan 2023, 64 (1) 137-144; DOI: 10.2967/jnumed.122.264284

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Antigen-Dependent Inducible T-Cell Reporter System for PET Imaging of Breast Cancer and Glioblastoma
Jaehoon Shin, Matthew F.L. Parker, Iowis Zhu, Aryn Alanizi, Carlos I. Rodriguez, Raymond Liu, Payal B. Watchmaker, Mausam Kalita, Joseph Blecha, Justin Luu, Brian Wright, Suzanne E. Lapi, Robert R. Flavell, Hideho Okada, Thea D. Tlsty, Kole T. Roybal, David M. Wilson
Journal of Nuclear Medicine Jan 2023, 64 (1) 137-144; DOI: 10.2967/jnumed.122.264284
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