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Meeting ReportAutomation & Technology Development

Fully automated, commercial cassette-based production of high-purity [64Cu]CuCl2 from solid Ni target

Courtney Hollis, Hiu Lam, William Tieu and Mario Malinconico
Journal of Nuclear Medicine June 2022, 63 (supplement 2) 2754;
Courtney Hollis
1Molecular Imaging and Therapy Research Unit, South Australian Health and Medical Research Institute, Adelaide, AUSTRALIA
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Hiu Lam
1Molecular Imaging and Therapy Research Unit, South Australian Health and Medical Research Institute, Adelaide, AUSTRALIA
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William Tieu
2University of Adelaide - Australia
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Mario Malinconico
3COMECER S.p.A - Castel Bolognese - Italy
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Abstract

2754

Introduction: Copper-64 (64Cu) is an attractive radionuclide for nuclear medical imaging. This radionuclide decays with low energy positron emission (β+ 17.6%, Eavg = 653 keV) and intermediate half-life (t1/2 = 12.7 h). 64Cu is amenable for labelling both short (minutes) and long (hours/days) incubating biological vectors and is exemplified by the many reports of 64Cu labelled small molecule, peptides, proteins and nanoparticles. Clinical studies with 64Cu have also progressed significantly in the past two decades. This work focuses on obtaining high-purity [64Cu]CuCl2 via a cassette-based automated separation method using a one column approach implemented on the Taddeo-PRF chemistry platform.

Methods: 64Ni is electroplated onto a target shuttle and irradiated with 14.4 MeV protons to produce 64Cu. The irradiated target is dissolved and purified to obtain [64Cu]CuCl2. Two purification methods are tested on the ALCEO system (COMECER); 1. AG 1-X8 resin (Biorad); 2. TK201 resin (Triskem). ICP-MS has been performed to monitor the quality of [64Cu]CuCl2.

Results: 64Cu is produced using the AG 1-X8 method with a yield of 2.49 ± 0.67 MBq/µAh/mg (N=21), electroplating 53.93 ± 20.42 mg of 64Ni and bombarding at 35 ± 0.2 µA for 247.95 ± 74.74 minutes with a proton beam. For the TK201 method, the yield is 2.30 ± 0.83 MBq/µAh/mg (N=61), electroplating 69.50 ± 17.61 mg of 64Ni and bombarding at 35 ± 0.2 µA for 201.13 ± 58.10 minutes. ICP-MS shows for the AG 1-X8 method (N=12): [Ni-64] 70728 ± 81643 ppb, [Cu] 1125 ± 657 ppb, [Fe] 8040 ± 4287 ppb, [Al] 3303 ± 1925 ppb, [Zn] 2336 ± 2602 ppb, [Co] 33 ± 35 ppb. Instead, for the TK201 method shows (N=30): [Ni-64] 8966 ± 11045 ppb, [Cu] 1244 ± 1636 ppb, [Fe] 426 ± 408 ppb, [Al] 1499 ± 2042 ppb, [Zn] 2717 ± 7196 ppb, [Co] 66 ± 84 ppb.

Conclusions: An automated method capable of producing high purity 64Cu from 64Ni targets has been developed. In summary, the entire process can be achieved in ~ 120 min (60 min for dissolution and resin loading, 30 min for resin elution and 30 min for evaporation of the 0.5 M acid)  min from EoB to EoS, with average yields of 2.54 ± 0.8 MBq/µAh/mg when irradiating with 35 μA for 2.5 to 3.5 h. The quality of the final product has been tested and it is suitable for all labelling processes.

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Journal of Nuclear Medicine
Vol. 63, Issue supplement 2
June 1, 2022
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Fully automated, commercial cassette-based production of high-purity [64Cu]CuCl2 from solid Ni target
Courtney Hollis, Hiu Lam, William Tieu, Mario Malinconico
Journal of Nuclear Medicine Jun 2022, 63 (supplement 2) 2754;

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Fully automated, commercial cassette-based production of high-purity [64Cu]CuCl2 from solid Ni target
Courtney Hollis, Hiu Lam, William Tieu, Mario Malinconico
Journal of Nuclear Medicine Jun 2022, 63 (supplement 2) 2754;
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