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- FIGURE 1.
Translocator protein 18 kDa (TSPO) PET in AD. Inflammation imaging at presymptomatic, MCI, and dementia stages of AD process. In each subject, multimodal imaging is shown, to illustrate spatial correlation of inflammation, in bottom row of every individual scan, with amyloid and tau imaging. CDR = clinical dementia rating scale; HAB = TSPO-high-affinity binder subject; MAB = TSPO-mixed-affinity binder subject; SUVR = standardized uptake value ratio; VT = volume of distribution.
- FIGURE 2.
TSPO PET in FTD. Inflammation imaging in behavioral variant of FTD and in the nonfluent and semantic variants of primary progressive aphasia (PPA), also categorized as FTD. Amyloid PET was negative in all subjects. In semantic variant PPA, peak of inflammation is at periphery of most affected area, which has atrophy on MRI. HAB = TSPO-high-affinity binder subject; MAB = TSPO-mixed-affinity binder subject; SUVR = standardized uptake value ratio; VT = volume of distribution. (Lower 2 panels are adapted with permission of (71)).
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- Abstract
- TSPO PET: CURRENT TARGET TO IMAGE NEUROINFLAMMATION
- NEUROINFLAMMATION PET IN NEURODEGENERATIVE DISORDERS
- LIMITATIONS OF TSPO PET
- NEW INFLAMMATION IMAGING TARGETS TO OVERCOME THE LIMITATIONS OF TSPO PET
- OTHER PET MARKERS TO STUDY NEUROINFLAMMATION
- LINKAGE BETWEEN PERIPHERAL AND CENTRAL INFLAMMATION
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