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Research ArticleClinical Investigation

The Impact of Semiautomatic Segmentation Methods on Metabolic Tumor Volume, Intensity, and Dissemination Radiomics in 18F-FDG PET Scans of Patients with Classical Hodgkin Lymphoma

Julia Driessen, Gerben J.C. Zwezerijnen, Heiko Schöder, Esther E.E. Drees, Marie José Kersten, Alison J. Moskowitz, Craig H. Moskowitz, Jakoba J. Eertink, Henrica C.W. de Vet, Otto S. Hoekstra, Josée M. Zijlstra and Ronald Boellaard
Journal of Nuclear Medicine September 2022, 63 (9) 1424-1430; DOI: https://doi.org/10.2967/jnumed.121.263067
Julia Driessen
1Department of Hematology, Amsterdam UMC, University of Amsterdam, LYMMCARE (Lymphoma and Myeloma Center, Amsterdam), Cancer Center Amsterdam, Amsterdam, The Netherlands;
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Gerben J.C. Zwezerijnen
2Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands;
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Heiko Schöder
3Department of Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York;
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Esther E.E. Drees
4Department of Pathology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands;
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Marie José Kersten
1Department of Hematology, Amsterdam UMC, University of Amsterdam, LYMMCARE (Lymphoma and Myeloma Center, Amsterdam), Cancer Center Amsterdam, Amsterdam, The Netherlands;
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Alison J. Moskowitz
5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York;
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Craig H. Moskowitz
6Department of Medicine, Sylvester Comprehensive Cancer Center, Miami, Florida;
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Jakoba J. Eertink
7Department of Hematology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands; and
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Henrica C.W. de Vet
8Department of Epidemiology and Data Science, Amsterdam Public Health research institute, Amsterdam, Netherlands
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Otto S. Hoekstra
2Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands;
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Josée M. Zijlstra
7Department of Hematology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands; and
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Ronald Boellaard
2Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands;
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Article Information

vol. 63 no. 9 1424-1430
DOI 
https://doi.org/10.2967/jnumed.121.263067
PubMed 
34992152

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication August 17, 2021
  • Revision received December 28, 2021
  • Published online September 1, 2022.

Article Versions

  • previous version (January 6, 2022 - 13:04).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2022 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Julia Driessen*,1,
  2. Gerben J.C. Zwezerijnen*,2,
  3. Heiko Schöder3,
  4. Esther E.E. Drees4,
  5. Marie José Kersten1,
  6. Alison J. Moskowitz5,
  7. Craig H. Moskowitz6,
  8. Jakoba J. Eertink7,
  9. Henrica C.W. de Vet8,
  10. Otto S. Hoekstra2,
  11. Josée M. Zijlstra7 and
  12. Ronald Boellaard2
  1. 1Department of Hematology, Amsterdam UMC, University of Amsterdam, LYMMCARE (Lymphoma and Myeloma Center, Amsterdam), Cancer Center Amsterdam, Amsterdam, The Netherlands;
  2. 2Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands;
  3. 3Department of Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York;
  4. 4Department of Pathology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands;
  5. 5Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York;
  6. 6Department of Medicine, Sylvester Comprehensive Cancer Center, Miami, Florida;
  7. 7Department of Hematology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands; and
  8. 8Department of Epidemiology and Data Science, Amsterdam Public Health research institute, Amsterdam, Netherlands
  1. For correspondence or reprints, contact Ronald Boellaard (r.boellaard{at}amsterdamumc.nl).
  1. ↵* Contributed equally to this work.

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Journal of Nuclear Medicine: 63 (9)
Journal of Nuclear Medicine
Vol. 63, Issue 9
September 1, 2022
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The Impact of Semiautomatic Segmentation Methods on Metabolic Tumor Volume, Intensity, and Dissemination Radiomics in 18F-FDG PET Scans of Patients with Classical Hodgkin Lymphoma
Julia Driessen, Gerben J.C. Zwezerijnen, Heiko Schöder, Esther E.E. Drees, Marie José Kersten, Alison J. Moskowitz, Craig H. Moskowitz, Jakoba J. Eertink, Henrica C.W. de Vet, Otto S. Hoekstra, Josée M. Zijlstra, Ronald Boellaard
Journal of Nuclear Medicine Sep 2022, 63 (9) 1424-1430; DOI: 10.2967/jnumed.121.263067

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The Impact of Semiautomatic Segmentation Methods on Metabolic Tumor Volume, Intensity, and Dissemination Radiomics in 18F-FDG PET Scans of Patients with Classical Hodgkin Lymphoma
Julia Driessen, Gerben J.C. Zwezerijnen, Heiko Schöder, Esther E.E. Drees, Marie José Kersten, Alison J. Moskowitz, Craig H. Moskowitz, Jakoba J. Eertink, Henrica C.W. de Vet, Otto S. Hoekstra, Josée M. Zijlstra, Ronald Boellaard
Journal of Nuclear Medicine Sep 2022, 63 (9) 1424-1430; DOI: 10.2967/jnumed.121.263067
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  • International Benchmark for Total Metabolic Tumor Volume Measurement in Baseline 18F-FDG PET/CT of Lymphoma Patients: A Milestone Toward Clinical Implementation
  • Total metabolic tumor volume on 18F-FDG PET/CT is a game-changer for patients with metastatic lung cancer treated with immunotherapy
  • Is 18F-FDG Metabolic Tumor Volume in Lymphoma Really Happening?
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Keywords

  • Hodgkin lymphoma
  • segmentation methods
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  • outcome prediction
  • radiomics
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