Optimizing Immuno-PET Imaging of Tumor PD-L1 Expression: Pharmacokinetic, Biodistribution, and Dosimetric Comparisons of 89Zr-Labeled Anti-PD-L1 Antibody Formats

Alizée Bouleau; Hervé Nozach; Steven Dubois; Dimitri Kereselidze; Céline Chevaleyre; Cheng-I Wang; Michael J. Evans; Vincent Lebon; Bernard Maillère; Charles Truillet

doi:10.2967/jnumed.121.262967

Research ArticleBasic Science Investigation

Optimizing Immuno-PET Imaging of Tumor PD-L1 Expression: Pharmacokinetic, Biodistribution, and Dosimetric Comparisons of ⁸⁹Zr-Labeled Anti-PD-L1 Antibody Formats

Alizée Bouleau, Hervé Nozach, Steven Dubois, Dimitri Kereselidze, Céline Chevaleyre, Cheng-I Wang, Michael J. Evans, Vincent Lebon, Bernard Maillère and Charles Truillet

Journal of Nuclear Medicine August 2022, 63 (8) 1259-1265; DOI: https://doi.org/10.2967/jnumed.121.262967

Alizée Bouleau

1Paris-Saclay University, CEA, CNRS, INSERM, Multimodal Biomedical Imaging Lab, Orsay, France;

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Hervé Nozach

2Paris-Saclay University, CEA, INRAE, Medicines and Healthcare Technologies Department, SIMoS, Gif-sur-Yvette, France;

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Steven Dubois

2Paris-Saclay University, CEA, INRAE, Medicines and Healthcare Technologies Department, SIMoS, Gif-sur-Yvette, France;

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Dimitri Kereselidze

1Paris-Saclay University, CEA, CNRS, INSERM, Multimodal Biomedical Imaging Lab, Orsay, France;

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Céline Chevaleyre

1Paris-Saclay University, CEA, CNRS, INSERM, Multimodal Biomedical Imaging Lab, Orsay, France;

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Cheng-I Wang

3Singapore Immunology Network, A*STAR, Immunos, Singapore, Singapore; and

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Michael J. Evans

4Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California

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Vincent Lebon

1Paris-Saclay University, CEA, CNRS, INSERM, Multimodal Biomedical Imaging Lab, Orsay, France;

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Bernard Maillère

2Paris-Saclay University, CEA, INRAE, Medicines and Healthcare Technologies Department, SIMoS, Gif-sur-Yvette, France;

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Charles Truillet

1Paris-Saclay University, CEA, CNRS, INSERM, Multimodal Biomedical Imaging Lab, Orsay, France;

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Journal of Nuclear Medicine

Vol. 63, Issue 8

August 1, 2022

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Optimizing Immuno-PET Imaging of Tumor PD-L1 Expression: Pharmacokinetic, Biodistribution, and Dosimetric Comparisons of ⁸⁹Zr-Labeled Anti-PD-L1 Antibody Formats

Alizée Bouleau, Hervé Nozach, Steven Dubois, Dimitri Kereselidze, Céline Chevaleyre, Cheng-I Wang, Michael J. Evans, Vincent Lebon, Bernard Maillère, Charles Truillet

Journal of Nuclear Medicine Aug 2022, 63 (8) 1259-1265; DOI: 10.2967/jnumed.121.262967

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Optimizing Immuno-PET Imaging of Tumor PD-L1 Expression: Pharmacokinetic, Biodistribution, and Dosimetric Comparisons of ⁸⁹Zr-Labeled Anti-PD-L1 Antibody Formats

Alizée Bouleau, Hervé Nozach, Steven Dubois, Dimitri Kereselidze, Céline Chevaleyre, Cheng-I Wang, Michael J. Evans, Vincent Lebon, Bernard Maillère, Charles Truillet

Journal of Nuclear Medicine Aug 2022, 63 (8) 1259-1265; DOI: 10.2967/jnumed.121.262967

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Keywords

PET
programmed cell death ligand 1
PD-L1
immunotherapy
pharmacokinetics
non–small cell lung cancer
NSCLC

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Optimizing Immuno-PET Imaging of Tumor PD-L1 Expression: Pharmacokinetic, Biodistribution, and Dosimetric Comparisons of ⁸⁹Zr-Labeled Anti-PD-L1 Antibody Formats

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