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Journal of Nuclear Medicine

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Research ArticleBasic Science Investigation

PET Imaging of PD-L1 Occupancy for Preclinical Assessment of the Efficacy of Combined Anti–PD-L1 Immunotherapy and Targeted Therapy

Céline Chevaleyre, Léa Zimmermann, Simon Specklin, Dimitri Kereselidze, Alizée Bouleau, Steven Dubois, Hélène Quelquejay, Bernard Maillère, Nicolas Tournier, Hervé Nozach and Charles Truillet
Journal of Nuclear Medicine April 2025, 66 (4) 559-564; DOI: https://doi.org/10.2967/jnumed.124.268586
Céline Chevaleyre
1BioMaps, Service Hospitalier Frédéric Joliot, INSERM, CNRS, CEA, Paris-Saclay University, Orsay, France; and
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Léa Zimmermann
1BioMaps, Service Hospitalier Frédéric Joliot, INSERM, CNRS, CEA, Paris-Saclay University, Orsay, France; and
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Simon Specklin
1BioMaps, Service Hospitalier Frédéric Joliot, INSERM, CNRS, CEA, Paris-Saclay University, Orsay, France; and
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Dimitri Kereselidze
1BioMaps, Service Hospitalier Frédéric Joliot, INSERM, CNRS, CEA, Paris-Saclay University, Orsay, France; and
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Alizée Bouleau
1BioMaps, Service Hospitalier Frédéric Joliot, INSERM, CNRS, CEA, Paris-Saclay University, Orsay, France; and
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Steven Dubois
2SIMoS, Healthcare Technologies Department, INRAE, CEA, Paris-Saclay University, Gif-sur-Yvette, France
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Hélène Quelquejay
1BioMaps, Service Hospitalier Frédéric Joliot, INSERM, CNRS, CEA, Paris-Saclay University, Orsay, France; and
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Bernard Maillère
2SIMoS, Healthcare Technologies Department, INRAE, CEA, Paris-Saclay University, Gif-sur-Yvette, France
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Nicolas Tournier
1BioMaps, Service Hospitalier Frédéric Joliot, INSERM, CNRS, CEA, Paris-Saclay University, Orsay, France; and
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Hervé Nozach
2SIMoS, Healthcare Technologies Department, INRAE, CEA, Paris-Saclay University, Gif-sur-Yvette, France
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Charles Truillet
1BioMaps, Service Hospitalier Frédéric Joliot, INSERM, CNRS, CEA, Paris-Saclay University, Orsay, France; and
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Journal of Nuclear Medicine: 66 (4)
Journal of Nuclear Medicine
Vol. 66, Issue 4
April 1, 2025
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PET Imaging of PD-L1 Occupancy for Preclinical Assessment of the Efficacy of Combined Anti–PD-L1 Immunotherapy and Targeted Therapy
Céline Chevaleyre, Léa Zimmermann, Simon Specklin, Dimitri Kereselidze, Alizée Bouleau, Steven Dubois, Hélène Quelquejay, Bernard Maillère, Nicolas Tournier, Hervé Nozach, Charles Truillet
Journal of Nuclear Medicine Apr 2025, 66 (4) 559-564; DOI: 10.2967/jnumed.124.268586

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PET Imaging of PD-L1 Occupancy for Preclinical Assessment of the Efficacy of Combined Anti–PD-L1 Immunotherapy and Targeted Therapy
Céline Chevaleyre, Léa Zimmermann, Simon Specklin, Dimitri Kereselidze, Alizée Bouleau, Steven Dubois, Hélène Quelquejay, Bernard Maillère, Nicolas Tournier, Hervé Nozach, Charles Truillet
Journal of Nuclear Medicine Apr 2025, 66 (4) 559-564; DOI: 10.2967/jnumed.124.268586
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Keywords

  • dose occupancy
  • immuno-PET imaging
  • combination therapy
  • immunotherapy
  • BRD4 inhibitor
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