Research ArticleArticle

First-in-Humans Brain PET Imaging of the GluN2B-Containing N-methyl-d-aspartate Receptor with (R)-11C-Me-NB1

Lucas Rischka, Chrysoula Vraka, Verena Pichler, Sazan Rasul, Lukas Nics, Gregor Gryglewski, Patricia Handschuh, Matej Murgaš, Godber M. Godbersen, Leo R. Silberbauer, Jakob Unterholzner, Christoph Wotawa, Achi Haider, Hazem Ahmed, Roger Schibli, Thomas Mindt, Markus Mitterhauser, Wolfgang Wadsak, Andreas Hahn, Rupert Lanzenberger, Marcus Hacker and Simon M. Ametamey
Journal of Nuclear Medicine June 2022, 63 (6) 936-941; DOI: https://doi.org/10.2967/jnumed.121.262427

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  • Figure
  • FIGURE 1.
    FIGURE 1.

    Chemical structure of (R)-11C-Me-NB1.

  • FIGURE 2.
    FIGURE 2.

    ROIs and SUVmean maps. First row depicts investigated ROIs covering cortical, subcortical, and white matter structures: 1, frontal cortex; 2, somatosensory cortex; 3, parietal cortex; 4, occipital cortex; 5, cingulate cortex; 6, thalamus; 7, corpus callosum; 8, cerebellar gray matter; 9, hippocampus; 10, centrum semiovale; 11, temporal cortex; 12, striatum. Amygdala and cerebellar white matter are not visible in the presented slices (MNI space, x = −4, y = 16, z = 7 mm). Remaining rows depict radioligand distribution in terms of SUV for various time points (averaged across subjects).

  • FIGURE 3.
    FIGURE 3.

    Kinetics of (R)-11C-Me-NB1. Reversible kinetics were obtained within measurement time. (A) Time–activity curves demonstrate homogeneous kinetics in cortical regions. (B) Subcortical regions showed variable kinetics, with highest uptake observed in striatum. Lowest SUV and markedly different kinetics were observed in centrum semiovale and corpus callosum.

  • FIGURE 4.
    FIGURE 4.

    SUV and VT using Logan plot. (A) SUV of each ROI for several time points. (B) Exploratory VT computed with Logan plot.

  • FIGURE 5.
    FIGURE 5.

    Absolute percentage difference (APD) of SUV and Logan plot. (A) APD of SUV is comparable over time in most regions with slightly larger interquartile ranges for 40–60 min. (B) APD of Logan plot visualizes similar median differences as for SUV but with 1 outlier.

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