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Research ArticleClinical Investigation

Combined Metabolically Active Tumor Volume and Early Metabolic Response Improve Outcome Prediction in Metastatic Colorectal Cancer

Erwin Woff, Lisa Salvatore, Federica Marmorino, Dario Genovesi, Gabriela Critchi, Thomas Guiot, Lieveke Ameye, Francesco Sclafani, Alain Hendlisz and Patrick Flamen
Journal of Nuclear Medicine April 2022, 63 (4) 549-555; DOI: https://doi.org/10.2967/jnumed.120.245357
Erwin Woff
1Nuclear Medicine Department, Institut Jules Bordet–Université Libre de Bruxelles (ULB), Brussels, Belgium;
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Lisa Salvatore
2Medical Oncology Department, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy;
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Federica Marmorino
3Department of Translational Research and New Technologies in Medicine and Surgery, Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy;
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Dario Genovesi
4Nuclear Medicine Department, Fondazione Toscana “Gabriele Monasterio,” Pisa, Italy;
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Gabriela Critchi
1Nuclear Medicine Department, Institut Jules Bordet–Université Libre de Bruxelles (ULB), Brussels, Belgium;
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Thomas Guiot
1Nuclear Medicine Department, Institut Jules Bordet–Université Libre de Bruxelles (ULB), Brussels, Belgium;
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Lieveke Ameye
5Data Centre, Institut Jules Bordet–Université Libre de Bruxelles (ULB), Brussels, Belgium; and
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Francesco Sclafani
6Medical Oncology Department, Institut Jules Bordet–Université Libre de Bruxelles (ULB), Brussels, Belgium
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Alain Hendlisz
6Medical Oncology Department, Institut Jules Bordet–Université Libre de Bruxelles (ULB), Brussels, Belgium
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Patrick Flamen
1Nuclear Medicine Department, Institut Jules Bordet–Université Libre de Bruxelles (ULB), Brussels, Belgium;
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Article Information

vol. 63 no. 4 549-555
DOI 
https://doi.org/10.2967/jnumed.120.245357
PubMed 
34326124

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication February 26, 2021
  • Revision received June 29, 2021
  • Published online March 31, 2022.

Article Versions

  • previous version (July 29, 2021 - 14:49).
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Copyright & Usage 
© 2022 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Erwin Woff1,
  2. Lisa Salvatore2,
  3. Federica Marmorino3,
  4. Dario Genovesi4,
  5. Gabriela Critchi1,
  6. Thomas Guiot1,
  7. Lieveke Ameye5,
  8. Francesco Sclafani6,
  9. Alain Hendlisz*,6 and
  10. Patrick Flamen*,1
  1. 1Nuclear Medicine Department, Institut Jules Bordet–Université Libre de Bruxelles (ULB), Brussels, Belgium;
  2. 2Medical Oncology Department, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy;
  3. 3Department of Translational Research and New Technologies in Medicine and Surgery, Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy;
  4. 4Nuclear Medicine Department, Fondazione Toscana “Gabriele Monasterio,” Pisa, Italy;
  5. 5Data Centre, Institut Jules Bordet–Université Libre de Bruxelles (ULB), Brussels, Belgium; and
  6. 6Medical Oncology Department, Institut Jules Bordet–Université Libre de Bruxelles (ULB), Brussels, Belgium
  1. For correspondence or reprints, contact Erwin Woff (erwin.woff{at}bordet.be).
  1. ↵* Contributed equally to this work.

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Journal of Nuclear Medicine: 63 (4)
Journal of Nuclear Medicine
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April 1, 2022
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Combined Metabolically Active Tumor Volume and Early Metabolic Response Improve Outcome Prediction in Metastatic Colorectal Cancer
Erwin Woff, Lisa Salvatore, Federica Marmorino, Dario Genovesi, Gabriela Critchi, Thomas Guiot, Lieveke Ameye, Francesco Sclafani, Alain Hendlisz, Patrick Flamen
Journal of Nuclear Medicine Apr 2022, 63 (4) 549-555; DOI: 10.2967/jnumed.120.245357

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Combined Metabolically Active Tumor Volume and Early Metabolic Response Improve Outcome Prediction in Metastatic Colorectal Cancer
Erwin Woff, Lisa Salvatore, Federica Marmorino, Dario Genovesi, Gabriela Critchi, Thomas Guiot, Lieveke Ameye, Francesco Sclafani, Alain Hendlisz, Patrick Flamen
Journal of Nuclear Medicine Apr 2022, 63 (4) 549-555; DOI: 10.2967/jnumed.120.245357
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Keywords

  • 18F-FDG PET/CT-based biomarkers
  • metabolically active tumor volume
  • early metabolic response
  • metastatic colorectal cancer
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