Article Figures & Data
Figures
- FIGURE 1.
(A) Nigrostriatal dopaminergic white matter tracts identified in PD group in MA and least affected hemispheres (overlaid on T1-weighted MR image in Montreal Neurologic Institute space). (B) Voxel-based correlation analysis showing negative correlation between mean QA of MA tract and 18F-FEOBV DVR in posterior putamen of same hemisphere. (C) Negative correlation between mean QA of MA tract and mean 18F-FEOBV DVR within putaminal SPM-based VOI (95% CI, −0.76 to −0.2). (D) Significantly higher mean 18F-FEOBV DVR within that putaminal VOI in PD group than in healthy control (NC) group.
- FIGURE 2.
(A) Relation between training (predicted values) and cross-validation (observed values) sets using LOO approach (mean QA and mean QA-LOO, respectively) in MA hemisphere of PD subjects. (B) Same as shown in A, but for VOI model derived from SPM voxel-based correlation analysis (VOI and VOI-LOO, respectively). (C) Negative correlation between mean QA-LOO of MA tract and mean 18F-FEOBV DVR within VOI-LOO (95% CI, −0.75 to −0.09). (D) Significantly higher mean 18F-FEOBV DVR within VOI-LOO in PD group than in healthy control (NC) group. NRMSE = normalized root-mean-square error.
- FIGURE 3.
Negative correlation between mean 18F-FEOBV DVR within significant cluster correlated with mean QA in MA hemisphere (Fig. 1B) and ipsilateral whole striatum11C-DTBZ DVR (95% CI, −0.55 to −0.02).
- FIGURE 4.
Voxel-based group comparison showing asymmetric bilateral putaminal 18F-FEOBV DVR increases (more extensive in MA hemisphere [left]), compared with control group (Table 2). There is partial topographic overlap of MA side with results of voxel-based correlation analysis in PD group (Fig. 1B, z = 6–4 mm [left]).
- FIGURE 5.
(A) Positive correlation between bradykinesia subscore and proxy measure of acetylcholine–dopamine imbalance in MA hemisphere in subjects with PD (95% CI, 0.15–0.62). (B) Same as shown in A, but using measures derived from LOO cross-validation analysis (95% CI, 0.07–0.59). (C) Negative correlation between bradykinesia subscore and mean QA in MA hemisphere (95% CI, −0.63 to −0.01). (D) Positive correlation between bradykinesia subscore and mean 18F-FEOBV DVR within putaminal SPM-based VOI in MA hemisphere (95% CI, 0.1–0.58).
Tables
Characteristic PD (n = 45) Control (n = 15) Statistical significance Age (y) 66.3 ± 6.3 69.1 ± 8.6 t = 1.3; P = 0.19 Sex χ2 = 2.4; P = 0.12 Male 36 9 Female 9 6 Handedness χ2 = 0.25; P = 0.62 Right 41 13 Left 4 2 MoCA 27.0 ± 2.6 27.6 ± 1.8 t = 0.87; P = 0.39 MDS-UPDRS Part I 5.1 ± 4.5 Part II 5.5 ± 3.5 Part III 34.3 ± 13.2 Bradykinesia subscore* 11.6 ± 5.9 Tremor subscore* 8.8 ± 4.4 Rigidity subscore* 7.5 ± 2.9 PIGD subscore* 2.5 ± 2 MDS-UPDRS (I–III) total score 44.9 ± 16.8 Hoehn and Yahr stage 2.2 ± 0.6 (median, 2.5; range, 1–3) Disease duration (y) 5.8 ± 3.6 Levodopa equivalent dose (mg) 636.6 ± 374.5 *Derived from MDS-UPDRS (part III).
MoCA = Montreal cognitive assessment; MDS-UPDRS = Movement Disorder Society revised unified Parkinson disease rating scale; PIGD = postural instability and gait difficulties.
Striatal region P Cluster size Montreal Neurologic Institute coordinates (x, y, z) of maximum peak Peak-level t value MA putamen 0.028 369 voxels −32, −8, 5 3.93 Least affected putamen 0.043 188 voxels 32, −9, 6 4.15 P value is corrected for multiple comparisons at cluster level by using familywise error approach.
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