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Research ArticleFeatured Basic Science Article

An Improved 211At-Labeled Agent for PSMA-Targeted α-Therapy

Ronnie C. Mease, Choong Mo Kang, Vivek Kumar, Sangeeta Ray Banerjee, Il Minn, Mary Brummet, Kathleen L. Gabrielson, Yutian Feng, Andrew Park, Ana P. Kiess, George Sgouros, Ganesan Vaidyanathan, Michael R. Zalutsky and Martin G. Pomper
Journal of Nuclear Medicine February 2022, 63 (2) 259-267; DOI: https://doi.org/10.2967/jnumed.121.262098
Ronnie C. Mease
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland;
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Choong Mo Kang
2Department of Radiology, Duke University Medical Center, Durham, North Carolina;
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Vivek Kumar
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland;
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Sangeeta Ray Banerjee
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland;
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Il Minn
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland;
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Mary Brummet
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland;
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Kathleen L. Gabrielson
3Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and
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Yutian Feng
2Department of Radiology, Duke University Medical Center, Durham, North Carolina;
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Andrew Park
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland;
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Ana P. Kiess
4Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
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George Sgouros
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland;
4Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
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Ganesan Vaidyanathan
2Department of Radiology, Duke University Medical Center, Durham, North Carolina;
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Michael R. Zalutsky
2Department of Radiology, Duke University Medical Center, Durham, North Carolina;
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Martin G. Pomper
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland;
4Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland
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Journal of Nuclear Medicine: 63 (2)
Journal of Nuclear Medicine
Vol. 63, Issue 2
February 1, 2022
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An Improved 211At-Labeled Agent for PSMA-Targeted α-Therapy
Ronnie C. Mease, Choong Mo Kang, Vivek Kumar, Sangeeta Ray Banerjee, Il Minn, Mary Brummet, Kathleen L. Gabrielson, Yutian Feng, Andrew Park, Ana P. Kiess, George Sgouros, Ganesan Vaidyanathan, Michael R. Zalutsky, Martin G. Pomper
Journal of Nuclear Medicine Feb 2022, 63 (2) 259-267; DOI: 10.2967/jnumed.121.262098

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An Improved 211At-Labeled Agent for PSMA-Targeted α-Therapy
Ronnie C. Mease, Choong Mo Kang, Vivek Kumar, Sangeeta Ray Banerjee, Il Minn, Mary Brummet, Kathleen L. Gabrielson, Yutian Feng, Andrew Park, Ana P. Kiess, George Sgouros, Ganesan Vaidyanathan, Michael R. Zalutsky, Martin G. Pomper
Journal of Nuclear Medicine Feb 2022, 63 (2) 259-267; DOI: 10.2967/jnumed.121.262098
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  • Is 211At Really Happening?
  • Development and Preclinical Evaluation of [211At]PSAt-3-Ga: An Inhibitor for Targeted {alpha}-Therapy of Prostate Cancer
  • Effective Treatment of Human Breast Carcinoma Xenografts with Single-Dose 211At-Labeled Anti-HER2 Single-Domain Antibody Fragment
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Show more FEATURED BASIC SCIENCE ARTICLE

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Keywords

  • prostate cancer
  • α-emitter
  • radiopharmaceutical therapy
  • 211At
  • PSMA
  • murine models
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