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Research ArticleBasic Science Investigation

Synthesis and Preclinical Evaluation of 18F-Labeled Ketoprofen Methyl Esters for Cyclooxygenase-1 Imaging in Neuroinflammation

Miho Shukuri, Aya Mawatari, Shuhei Takatani, Tsuyoshi Tahara, Michiko Inoue, Wakiko Arakaki, Masahiro Ohno, Hisashi Doi and Hirotaka Onoe
Journal of Nuclear Medicine November 2022, 63 (11) 1761-1767; DOI: https://doi.org/10.2967/jnumed.121.263713
Miho Shukuri
1Laboratory of Physical Chemistry, Showa Pharmaceutical University, Tokyo, Japan;
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Aya Mawatari
2Laboratory for Labeling Chemistry, RIKEN Center for Biosystems Dynamics Research, Hyogo, Japan;
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Shuhei Takatani
2Laboratory for Labeling Chemistry, RIKEN Center for Biosystems Dynamics Research, Hyogo, Japan;
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Tsuyoshi Tahara
3Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, Hyogo, Japan;
4Department of in vivo Imaging, Advanced Research Promotion Center, Tokushima University, Tokushima, Japan;
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Michiko Inoue
3Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, Hyogo, Japan;
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Wakiko Arakaki
2Laboratory for Labeling Chemistry, RIKEN Center for Biosystems Dynamics Research, Hyogo, Japan;
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Masahiro Ohno
5Laboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics Research, Hyogo, Japan; and
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Hisashi Doi
2Laboratory for Labeling Chemistry, RIKEN Center for Biosystems Dynamics Research, Hyogo, Japan;
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Hirotaka Onoe
6Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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Article Information

vol. 63 no. 11 1761-1767
DOI 
https://doi.org/10.2967/jnumed.121.263713
PubMed 
35332095

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication December 22, 2021
  • Revision received March 2, 2022
  • Published online November 1, 2022.

Article Versions

  • previous version (March 24, 2022 - 11:46).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2022 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Miho Shukuri*,1,
  2. Aya Mawatari*,2,
  3. Shuhei Takatani2,
  4. Tsuyoshi Tahara3,4,
  5. Michiko Inoue3,
  6. Wakiko Arakaki2,
  7. Masahiro Ohno5,
  8. Hisashi Doi2 and
  9. Hirotaka Onoe6
  1. 1Laboratory of Physical Chemistry, Showa Pharmaceutical University, Tokyo, Japan;
  2. 2Laboratory for Labeling Chemistry, RIKEN Center for Biosystems Dynamics Research, Hyogo, Japan;
  3. 3Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, Hyogo, Japan;
  4. 4Department of in vivo Imaging, Advanced Research Promotion Center, Tokushima University, Tokushima, Japan;
  5. 5Laboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics Research, Hyogo, Japan; and
  6. 6Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  1. For correspondence or reprints, contact Hisashi Doi (hisashi.doi{at}riken.jp) or Hirotaka Onoe (h_onoe{at}kuhp.kyoto-u.ac.jp).
  1. ↵* Contributed equally to this work.

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Journal of Nuclear Medicine: 63 (11)
Journal of Nuclear Medicine
Vol. 63, Issue 11
November 1, 2022
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Synthesis and Preclinical Evaluation of 18F-Labeled Ketoprofen Methyl Esters for Cyclooxygenase-1 Imaging in Neuroinflammation
Miho Shukuri, Aya Mawatari, Shuhei Takatani, Tsuyoshi Tahara, Michiko Inoue, Wakiko Arakaki, Masahiro Ohno, Hisashi Doi, Hirotaka Onoe
Journal of Nuclear Medicine Nov 2022, 63 (11) 1761-1767; DOI: 10.2967/jnumed.121.263713

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Synthesis and Preclinical Evaluation of 18F-Labeled Ketoprofen Methyl Esters for Cyclooxygenase-1 Imaging in Neuroinflammation
Miho Shukuri, Aya Mawatari, Shuhei Takatani, Tsuyoshi Tahara, Michiko Inoue, Wakiko Arakaki, Masahiro Ohno, Hisashi Doi, Hirotaka Onoe
Journal of Nuclear Medicine Nov 2022, 63 (11) 1761-1767; DOI: 10.2967/jnumed.121.263713
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