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Research ArticleBasic Science Investigation

89Zr-3,2-HOPO-Mesothelin Antibody PET Imaging Reflects Tumor Uptake of Mesothelin-Targeted 227Th-Conjugate Therapy in Mice

Linda N. Broer, Daan G. Knapen, Frans V. Suurs, Ingrid Moen, Danique Giesen, Stijn J.H. Waaijer, Baard Indrevoll, Christine Ellingsen, Alexander Kristian, Alan S. Cuthbertson, Derk-Jan A. de Groot, Patricia E. Cole, Elisabeth G.E. de Vries, Urs B. Hagemann and Marjolijn N. Lub-de Hooge
Journal of Nuclear Medicine November 2022, 63 (11) 1715-1721; DOI: https://doi.org/10.2967/jnumed.121.263079
Linda N. Broer
1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;
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Daan G. Knapen
1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;
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Frans V. Suurs
1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;
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Ingrid Moen
2Bayer AS, Oslo, Norway;
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Danique Giesen
1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;
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Stijn J.H. Waaijer
1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;
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Baard Indrevoll
2Bayer AS, Oslo, Norway;
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Christine Ellingsen
2Bayer AS, Oslo, Norway;
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Alexander Kristian
2Bayer AS, Oslo, Norway;
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Alan S. Cuthbertson
2Bayer AS, Oslo, Norway;
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Derk-Jan A. de Groot
1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;
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Patricia E. Cole
3Bayer U.S., LLC, Whippany, New Jersey;
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Elisabeth G.E. de Vries
1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;
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Urs B. Hagemann
4Bayer AG, Berlin, Germany;
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Marjolijn N. Lub-de Hooge
5Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and
6Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Article Information

vol. 63 no. 11 1715-1721
DOI 
https://doi.org/10.2967/jnumed.121.263079
PubMed 
35422447

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication August 19, 2021
  • Revision received March 23, 2022
  • Published online November 1, 2022.

Article Versions

  • previous version (April 14, 2022 - 12:36).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2022 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Linda N. Broer1,
  2. Daan G. Knapen1,
  3. Frans V. Suurs1,
  4. Ingrid Moen2,
  5. Danique Giesen1,
  6. Stijn J.H. Waaijer1,
  7. Baard Indrevoll2,
  8. Christine Ellingsen2,
  9. Alexander Kristian2,
  10. Alan S. Cuthbertson2,
  11. Derk-Jan A. de Groot1,
  12. Patricia E. Cole3,
  13. Elisabeth G.E. de Vries1,
  14. Urs B. Hagemann4 and
  15. Marjolijn N. Lub-de Hooge5,6
  1. 1Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;
  2. 2Bayer AS, Oslo, Norway;
  3. 3Bayer U.S., LLC, Whippany, New Jersey;
  4. 4Bayer AG, Berlin, Germany;
  5. 5Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and
  6. 6Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
  1. For correspondence or reprints, contact Marjolijn N. Lub-de Hooge (m.n.de.hooge{at}umcg.nl).
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Journal of Nuclear Medicine: 63 (11)
Journal of Nuclear Medicine
Vol. 63, Issue 11
November 1, 2022
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89Zr-3,2-HOPO-Mesothelin Antibody PET Imaging Reflects Tumor Uptake of Mesothelin-Targeted 227Th-Conjugate Therapy in Mice
Linda N. Broer, Daan G. Knapen, Frans V. Suurs, Ingrid Moen, Danique Giesen, Stijn J.H. Waaijer, Baard Indrevoll, Christine Ellingsen, Alexander Kristian, Alan S. Cuthbertson, Derk-Jan A. de Groot, Patricia E. Cole, Elisabeth G.E. de Vries, Urs B. Hagemann, Marjolijn N. Lub-de Hooge
Journal of Nuclear Medicine Nov 2022, 63 (11) 1715-1721; DOI: 10.2967/jnumed.121.263079

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89Zr-3,2-HOPO-Mesothelin Antibody PET Imaging Reflects Tumor Uptake of Mesothelin-Targeted 227Th-Conjugate Therapy in Mice
Linda N. Broer, Daan G. Knapen, Frans V. Suurs, Ingrid Moen, Danique Giesen, Stijn J.H. Waaijer, Baard Indrevoll, Christine Ellingsen, Alexander Kristian, Alan S. Cuthbertson, Derk-Jan A. de Groot, Patricia E. Cole, Elisabeth G.E. de Vries, Urs B. Hagemann, Marjolijn N. Lub-de Hooge
Journal of Nuclear Medicine Nov 2022, 63 (11) 1715-1721; DOI: 10.2967/jnumed.121.263079
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Keywords

  • PET imaging
  • 89Zr
  • targeted 227Th therapy
  • antibody conjugate
  • mesothelin
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