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Research ArticleClinical Investigation
Open Access

Analysis of Short-Term and Stable DNA Damage in Patients with Differentiated Thyroid Cancer Treated with 131I in Hypothyroidism or with Recombinant Human Thyroid-Stimulating Hormone for Remnant Ablation

Alberto Signore, Giuseppe Campagna, Jessica Marinaccio, Marco de Vitis, Chiara Lauri, Francesco Berardinelli, Anna Tofani, Marco Chianelli, Marina Borro, Giovanna Gentile, Maurizio Simmaco, Francesco Colombini, Anna Giovanetti and Antonella Sgura
Journal of Nuclear Medicine October 2022, 63 (10) 1515-1522; DOI: https://doi.org/10.2967/jnumed.121.263442
Alberto Signore
1Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, University of Rome “Sapienza,” Rome, Italy;
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Giuseppe Campagna
1Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, University of Rome “Sapienza,” Rome, Italy;
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Jessica Marinaccio
2Department of Science, University of Rome “Roma Tre,” Rome, Italy;
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Marco de Vitis
2Department of Science, University of Rome “Roma Tre,” Rome, Italy;
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Chiara Lauri
1Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, University of Rome “Sapienza,” Rome, Italy;
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Francesco Berardinelli
2Department of Science, University of Rome “Roma Tre,” Rome, Italy;
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Anna Tofani
1Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, University of Rome “Sapienza,” Rome, Italy;
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Marco Chianelli
3Unit of Endocrinology, Regina Apostolorum Hospital, Rome, Italy;
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Marina Borro
4Department of Neurosciences, Mental Health, and Sensory Organs, Faculty of Medicine and Psychology, University of Rome “Sapienza,” Rome, Italy;
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Giovanna Gentile
4Department of Neurosciences, Mental Health, and Sensory Organs, Faculty of Medicine and Psychology, University of Rome “Sapienza,” Rome, Italy;
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Maurizio Simmaco
4Department of Neurosciences, Mental Health, and Sensory Organs, Faculty of Medicine and Psychology, University of Rome “Sapienza,” Rome, Italy;
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Francesco Colombini
5Diacron International SRL, Grosseto, Italy; and
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Anna Giovanetti
6ENEA, Division of Health Protection Technologies, Casaccia Research Centre, Rome, Italy
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Antonella Sgura
2Department of Science, University of Rome “Roma Tre,” Rome, Italy;
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Article Information

vol. 63 no. 10 1515-1522
DOI 
https://doi.org/10.2967/jnumed.121.263442
PubMed 
35115370

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication October 27, 2021
  • Accepted for publication January 12, 2022
  • Published online October 3, 2022.

Article Versions

  • previous version (February 3, 2022 - 11:45).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2022 by the Society of Nuclear Medicine and Molecular Imaging. Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

Author Information

  1. Alberto Signore1,
  2. Giuseppe Campagna1,
  3. Jessica Marinaccio2,
  4. Marco de Vitis2,
  5. Chiara Lauri1,
  6. Francesco Berardinelli2,
  7. Anna Tofani1,
  8. Marco Chianelli3,
  9. Marina Borro4,
  10. Giovanna Gentile4,
  11. Maurizio Simmaco4,
  12. Francesco Colombini5,
  13. Anna Giovanetti6 and
  14. Antonella Sgura2
  1. 1Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, University of Rome “Sapienza,” Rome, Italy;
  2. 2Department of Science, University of Rome “Roma Tre,” Rome, Italy;
  3. 3Unit of Endocrinology, Regina Apostolorum Hospital, Rome, Italy;
  4. 4Department of Neurosciences, Mental Health, and Sensory Organs, Faculty of Medicine and Psychology, University of Rome “Sapienza,” Rome, Italy;
  5. 5Diacron International SRL, Grosseto, Italy; and
  6. 6ENEA, Division of Health Protection Technologies, Casaccia Research Centre, Rome, Italy
  1. For correspondence or reprints, contact Alberto Signore (alberto.signore{at}uniroma1.it).
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Journal of Nuclear Medicine: 63 (10)
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October 1, 2022
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Analysis of Short-Term and Stable DNA Damage in Patients with Differentiated Thyroid Cancer Treated with 131I in Hypothyroidism or with Recombinant Human Thyroid-Stimulating Hormone for Remnant Ablation
Alberto Signore, Giuseppe Campagna, Jessica Marinaccio, Marco de Vitis, Chiara Lauri, Francesco Berardinelli, Anna Tofani, Marco Chianelli, Marina Borro, Giovanna Gentile, Maurizio Simmaco, Francesco Colombini, Anna Giovanetti, Antonella Sgura
Journal of Nuclear Medicine Oct 2022, 63 (10) 1515-1522; DOI: 10.2967/jnumed.121.263442

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Analysis of Short-Term and Stable DNA Damage in Patients with Differentiated Thyroid Cancer Treated with 131I in Hypothyroidism or with Recombinant Human Thyroid-Stimulating Hormone for Remnant Ablation
Alberto Signore, Giuseppe Campagna, Jessica Marinaccio, Marco de Vitis, Chiara Lauri, Francesco Berardinelli, Anna Tofani, Marco Chianelli, Marina Borro, Giovanna Gentile, Maurizio Simmaco, Francesco Colombini, Anna Giovanetti, Antonella Sgura
Journal of Nuclear Medicine Oct 2022, 63 (10) 1515-1522; DOI: 10.2967/jnumed.121.263442
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Keywords

  • 131I
  • radiation-induced genetic damage
  • hypothyroidism
  • rhTSH
  • gene polymorphism
  • free oxygen radicals
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