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Table 1. Accuracy for the prediction of 2-year progression-free survival: The Lugano Classification vs. PERCIST Sensitivity, % (95% CI) Specificity, % (95% CI) PPV, % (95% CI) NPV, % (95% CI) Accuracy, % (95% CI) DS-5 (interim) 24 (9.4 - 45.1) 100 (96.2 – 100) 100 (54.1 – 100) 83.3 (75.2 – 89.7) 84.2 (76.4 – 90.2) PERCIST-66% (interim) 26.7 (7.8 - 55.1) 100 (95.1 – 100) 100 (39.8 – 100) 87.1 (78 – 93.4) 87.6 (79 – 93.7) Lugano (non-CMR) (EOT) 47.4 (24.4 – 71.1) 93.1 (86.4 – 97.2) 56.3 (29.9 – 80.2) 90.5 (83.2 – 95.3) 86 (78.5 – 91.6) PERCIST (non-CMR) (EOT) 47.4 (24.4 – 71.1) 91.8 (83 – 96.9) 57.1 (28.9 – 82.3) 88.2 (78.7 – 94.4) 83.3 (74 – 90.3) DS-5 = Deauville Score 5 for non-response. PERCIST-66% = PMR with ≤66% reduction in SULpeak, SMD, or PMD for non-response. EOT = end of treatment. Lugano = the Lugano Classification.
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