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Meeting ReportPoster - PhysicianPharm

FDG PET/CT for prognostic stratification of patients with nodal peripheral T cell lymphoma.

Woo Hee Choi, Eun Ji Han, Joo Hyun O and Seok-Goo Cho
Journal of Nuclear Medicine May 2021, 62 (supplement 1) 1687;
Woo Hee Choi
1Nuclear Medicine The Catholic University of Korea Seoul Korea, Republic of
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Eun Ji Han
1Nuclear Medicine The Catholic University of Korea Seoul Korea, Republic of
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Joo Hyun O
1Nuclear Medicine The Catholic University of Korea Seoul Korea, Republic of
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Seok-Goo Cho
2Hematology The Catholic University of Korea Seoul Korea, Republic of
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Abstract

1687

Objectives: This study aimed to evaluate the prognostic significance of FDG PET/CT in patients with nodal peripheral T cell lymphoma (PTCL).

Methods: We retrospectively reviewed 71 patients with histologically confirmed nodal PTCL who performed FDG PET/CT at baseline, after 3 cycles of first-line chemotherapy (interim), and after completion of chemotherapy (final). Response was assessed visually by Deauville 5-point scale (D5PS), and scores 1, 2, and 3 were considered PET-negative and scores 4 and 5 were considered PET-positive. The association between FDG PET response and survival was assessed using Cox regression analysis.

Results: In total, FDG PET/CT images of 71 patients (40 male and 31 female; median age, 57 years, range, 18-77 years) were included. Of these patients, 13 (18.3%) had interim PET-positive result and 13 (18.3%) had final PET-positive result. The median overall (OS) and progression-free survival (PFS) were 16 and 40 months, respectively. Interim PET-positive result was a significant independent prognostic factor for PFS (Hazard ratio 2.551, p=0.018) in both univariate and multivariate analysis. Final PET-positive result was a significant independent prognostic factor of poor PFS (Hazard ratio 2.826, p=0.011) and OS (Hazard ratio 4.546, p=0.001).

Conclusions: Interim and final PET/CT response based on D5PS were important prognostic parameters in patients with nodal PTCL.

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Journal of Nuclear Medicine
Vol. 62, Issue supplement 1
May 1, 2021
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FDG PET/CT for prognostic stratification of patients with nodal peripheral T cell lymphoma.
Woo Hee Choi, Eun Ji Han, Joo Hyun O, Seok-Goo Cho
Journal of Nuclear Medicine May 2021, 62 (supplement 1) 1687;

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FDG PET/CT for prognostic stratification of patients with nodal peripheral T cell lymphoma.
Woo Hee Choi, Eun Ji Han, Joo Hyun O, Seok-Goo Cho
Journal of Nuclear Medicine May 2021, 62 (supplement 1) 1687;
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