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Journal of Nuclear Medicine

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Meeting ReportPoster - PhysicianPharm

Physiological DCFPyL PSMA-Targeted Tracer Uptake in the Epididymis Head Newly Appreciated on Digital PET/CT

Peter George Maliha, Julia Singerman, Gad Abikhzer and Stephan Probst
Journal of Nuclear Medicine May 2021, 62 (supplement 1) 1321;
Peter George Maliha
1McGill University Health Center Montreal QC Canada
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Julia Singerman
2Universite de Montreal Montreal QC Canada
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Gad Abikhzer
3Jewish General Hospital Montreal QC Canada
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Stephan Probst
3Jewish General Hospital Montreal QC Canada
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Abstract

1321

Purpose: The published physiological distribution of prostate specific membrane antigen (PSMA) PET ligands includes normal uptake in the lacrimal glands, salivary glands, bowel, liver, spleen, kidneys and parasympathetic ganglia but does not include the epididymis. Methods: Retrospective review of 134 PSMA-targeted 2-(3-(1-carboxy-5-[(6-[18F]fluoropyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid (18F-DCFPyL) PET/CT scans performed on a latest generation digital scanner for radiotracer uptake in the epididymal head region was correlated with multiple clinical and laboratory factors.

Results: Physiologic PSMA radiotracer uptake in the epididymal head region was present in 57% of all subjects, including 29% in those with a total serum testosterone ≤ 5 nmol/L and 65% of patients with serum testosterone > 5 nmol/L, odds ratio of 0.21 (P < 0.01). Conclusion: Epididymal head uptake is physiologic and very common on digital PSMA PET/CT and is more frequent in patients with higher serum testosterone levels. The enhanced small structure detection of digital PET/CT is the most likely explanation for the novel visualization of this normal variant.

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Journal of Nuclear Medicine
Vol. 62, Issue supplement 1
May 1, 2021
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Physiological DCFPyL PSMA-Targeted Tracer Uptake in the Epididymis Head Newly Appreciated on Digital PET/CT
Peter George Maliha, Julia Singerman, Gad Abikhzer, Stephan Probst
Journal of Nuclear Medicine May 2021, 62 (supplement 1) 1321;

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Physiological DCFPyL PSMA-Targeted Tracer Uptake in the Epididymis Head Newly Appreciated on Digital PET/CT
Peter George Maliha, Julia Singerman, Gad Abikhzer, Stephan Probst
Journal of Nuclear Medicine May 2021, 62 (supplement 1) 1321;
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