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Research ArticleTheranostics

Peptide Receptor Radionuclide Therapy of Late-Stage Neuroendocrine Tumor Patients with Multiple Cycles of 177Lu-DOTA-EB-TATE

Qingxing Liu, Jie Zang, Huimin Sui, Jiakun Ren, Hua Guo, Hao Wang, Rongxi Wang, Orit Jacobson, Jingjing Zhang, Yuejuan Cheng, Zhaohui Zhu and Xiaoyuan Chen
Journal of Nuclear Medicine March 2021, 62 (3) 386-392; DOI: https://doi.org/10.2967/jnumed.120.248658
Qingxing Liu
1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
2Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, China
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Jie Zang
1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
2Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, China
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Huimin Sui
1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
2Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, China
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Jiakun Ren
1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
2Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, China
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Hua Guo
1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
2Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, China
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Hao Wang
1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
2Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, China
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Rongxi Wang
1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
2Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, China
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Orit Jacobson
3Departments of Diagnostic Radiology, Chemical and Biomolecular Engineering, Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore, Singapore
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Jingjing Zhang
4Theranostics Center for Molecular Radiotherapy and Precision Oncology, Zentralklinik Bad Berka, Bad Berka, Germany; and
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Yuejuan Cheng
5Division of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
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Zhaohui Zhu
1Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
2Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing, China
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Xiaoyuan Chen
3Departments of Diagnostic Radiology, Chemical and Biomolecular Engineering, Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore, Singapore
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  • FIGURE 1.
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    FIGURE 1.

    Participants’ flow chart of groups A–C. PD = progressive disease.

  • FIGURE 2.
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    FIGURE 2.

    Changes in WBC, hemoglobin, platelets, alanine aminotransferase, aspartate aminotransferase, and creatinine at baseline and at 1 and 4 wk after each cycle of PRRT in all patients (A and C) and in patients who completed 3 cycles of PRRT (B and D). Blue line = group A; red line = group B; green line = group C.

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    FIGURE 3.

    Representative images of partial remission in group A (A), group B (B), and group C (C).

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    TABLE 1

    Baseline Demographic and Clinical Characteristics

    CharacteristicGroup A (n = 12)Group B (n = 6)Group C (n = 14)
    Male747
    Female527
    Age (y)53 ± 1355 ± 1050 ± 10
    Primary tumor site
     Pancreas337
     Stomach100
     Duodenum113
     Rectum202
     Lung110
     Ovary000
     Carcinoma of  unknown primary001
     Multiple endocrine  neoplasia010
     Paraganglioma201
     Pheochromocytoma200
    Tumor grade
     1313
     29410
     3011
    Number of lesions
     1–10426
     1–20221
     >20627
    Metastases
     Liver9514
     Bone826
     Lymph nodes725
     Lung213
    Prior treatment
     Surgery927
     Somatostatin analog855
     Everolimus231
     Tyrosine kinase inhibitor159
     Chemotherapy236
     Radiotherapy111
     Transarterial  chemoembolization113
    Disease course (mo)58 ± 6458 ± 2655 ± 25
    • Qualitative data are numbers; continuous data are mean ± SD.

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Journal of Nuclear Medicine: 62 (3)
Journal of Nuclear Medicine
Vol. 62, Issue 3
March 1, 2021
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Peptide Receptor Radionuclide Therapy of Late-Stage Neuroendocrine Tumor Patients with Multiple Cycles of 177Lu-DOTA-EB-TATE
Qingxing Liu, Jie Zang, Huimin Sui, Jiakun Ren, Hua Guo, Hao Wang, Rongxi Wang, Orit Jacobson, Jingjing Zhang, Yuejuan Cheng, Zhaohui Zhu, Xiaoyuan Chen
Journal of Nuclear Medicine Mar 2021, 62 (3) 386-392; DOI: 10.2967/jnumed.120.248658

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Peptide Receptor Radionuclide Therapy of Late-Stage Neuroendocrine Tumor Patients with Multiple Cycles of 177Lu-DOTA-EB-TATE
Qingxing Liu, Jie Zang, Huimin Sui, Jiakun Ren, Hua Guo, Hao Wang, Rongxi Wang, Orit Jacobson, Jingjing Zhang, Yuejuan Cheng, Zhaohui Zhu, Xiaoyuan Chen
Journal of Nuclear Medicine Mar 2021, 62 (3) 386-392; DOI: 10.2967/jnumed.120.248658
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Keywords

  • 177Lu-DOTA-EB-TATE
  • neuroendocrine tumor
  • dose escalation
  • peptide receptor radionuclide therapy (PRRT)
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