Fluorescence-Guided Visualization of Soft-Tissue Sarcomas by Targeting Vascular Endothelial Growth Factor A: A Phase 1 Single-Center Clinical Trial

Pieter J. Steinkamp; Bobby K. Pranger; Mei-Fang Li; Matthijs D. Linssen; Floris J. Voskuil; Lukas B. Been; Barbara L. van Leeuwen; Albert J.H. Suurmeijer; Wouter B. Nagengast; Schelto Kruijff; Robert J. van Ginkel; Gooitzen M. van Dam

doi:10.2967/jnumed.120.245696

Research ArticleOncology

Fluorescence-Guided Visualization of Soft-Tissue Sarcomas by Targeting Vascular Endothelial Growth Factor A: A Phase 1 Single-Center Clinical Trial

Pieter J. Steinkamp, Bobby K. Pranger, Mei-Fang Li, Matthijs D. Linssen, Floris J. Voskuil, Lukas B. Been, Barbara L. van Leeuwen, Albert J.H. Suurmeijer, Wouter B. Nagengast, Schelto Kruijff, Robert J. van Ginkel and Gooitzen M. van Dam

Journal of Nuclear Medicine March 2021, 62 (3) 342-347; DOI: https://doi.org/10.2967/jnumed.120.245696

Pieter J. Steinkamp

1Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Bobby K. Pranger

1Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Mei-Fang Li

2ChangJiang Scholar’s Laboratory, Shantou University Medical College, Shantou, China

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Matthijs D. Linssen

3Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

4Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Floris J. Voskuil

5Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Lukas B. Been

1Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Barbara L. van Leeuwen

1Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Albert J.H. Suurmeijer

6Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Wouter B. Nagengast

4Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Schelto Kruijff

1Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

7Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and

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Robert J. van Ginkel

1Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

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Gooitzen M. van Dam

1Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

7Medical Imaging Center, Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; and

8AxelaRx/TRACER BV, Groningen, The Netherlands

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Journal of Nuclear Medicine

Vol. 62, Issue 3

March 1, 2021

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Fluorescence-Guided Visualization of Soft-Tissue Sarcomas by Targeting Vascular Endothelial Growth Factor A: A Phase 1 Single-Center Clinical Trial

Journal of Nuclear Medicine Mar 2021, 62 (3) 342-347; DOI: 10.2967/jnumed.120.245696

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Fluorescence-Guided Visualization of Soft-Tissue Sarcomas by Targeting Vascular Endothelial Growth Factor A: A Phase 1 Single-Center Clinical Trial

Journal of Nuclear Medicine Mar 2021, 62 (3) 342-347; DOI: 10.2967/jnumed.120.245696

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Keywords

Soft-tissue sarcoma
fluorescence-guided surgery
molecular imaging
vascular endothelial growth factor A
tumor targeting
near-infrared fluorescence

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Fluorescence-Guided Visualization of Soft-Tissue Sarcomas by Targeting Vascular Endothelial Growth Factor A: A Phase 1 Single-Center Clinical Trial

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