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Research ArticleBasic (Molecular Imaging: Animal Imaging)

A Noninvasive Method for Quantifying Cerebral Metabolic Rate of Oxygen by Hybrid PET/MRI: Validation in a Porcine Model

Lucas Narciso, Tracy Ssali, Linshan Liu, Heather Biernaski, John Butler, Laura Morrison, Jennifer Hadway, Jeffrey Corsaut, Justin W. Hicks, Michael C. Langham, Felix W. Wehrli, Hidehiro Iida and Keith St Lawrence
Journal of Nuclear Medicine December 2021, 62 (12) 1789-1796; DOI: https://doi.org/10.2967/jnumed.120.260521
Lucas Narciso
1Lawson Health Research Institute, London, Ontario, Canada;
2Department of Medical Biophysics, Western University, London, Ontario, Canada;
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Tracy Ssali
1Lawson Health Research Institute, London, Ontario, Canada;
2Department of Medical Biophysics, Western University, London, Ontario, Canada;
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Linshan Liu
1Lawson Health Research Institute, London, Ontario, Canada;
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Heather Biernaski
1Lawson Health Research Institute, London, Ontario, Canada;
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John Butler
1Lawson Health Research Institute, London, Ontario, Canada;
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Laura Morrison
1Lawson Health Research Institute, London, Ontario, Canada;
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Jennifer Hadway
1Lawson Health Research Institute, London, Ontario, Canada;
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Jeffrey Corsaut
1Lawson Health Research Institute, London, Ontario, Canada;
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Justin W. Hicks
1Lawson Health Research Institute, London, Ontario, Canada;
2Department of Medical Biophysics, Western University, London, Ontario, Canada;
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Michael C. Langham
3Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania;
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Felix W. Wehrli
3Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania;
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Hidehiro Iida
4University of Turku and Turku PET Centre, Turku, Finland; and
5 National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
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Keith St Lawrence
1Lawson Health Research Institute, London, Ontario, Canada;
2Department of Medical Biophysics, Western University, London, Ontario, Canada;
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Article Information

vol. 62 no. 12 1789-1796
DOI 
https://doi.org/10.2967/jnumed.120.260521
PubMed 
33741647

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication November 19, 2020
  • Revision received March 5, 2021
  • Published online December 1, 2021.

Article Versions

  • previous version (March 19, 2021 - 11:19).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2021 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Lucas Narciso1,2,
  2. Tracy Ssali1,2,
  3. Linshan Liu1,
  4. Heather Biernaski1,
  5. John Butler1,
  6. Laura Morrison1,
  7. Jennifer Hadway1,
  8. Jeffrey Corsaut1,
  9. Justin W. Hicks1,2,
  10. Michael C. Langham3,
  11. Felix W. Wehrli3,
  12. Hidehiro Iida4,5 and
  13. Keith St Lawrence1,2
  1. 1Lawson Health Research Institute, London, Ontario, Canada;
  2. 2Department of Medical Biophysics, Western University, London, Ontario, Canada;
  3. 3Department of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania;
  4. 4University of Turku and Turku PET Centre, Turku, Finland; and
  5. 5 National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
  1. For correspondence or reprints, contact Lucas Narciso (lnarciso{at}uwo.ca) and Keith St Lawrence (kstlaw{at}lawsonimaging.ca).
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Journal of Nuclear Medicine: 62 (12)
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December 1, 2021
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A Noninvasive Method for Quantifying Cerebral Metabolic Rate of Oxygen by Hybrid PET/MRI: Validation in a Porcine Model
Lucas Narciso, Tracy Ssali, Linshan Liu, Heather Biernaski, John Butler, Laura Morrison, Jennifer Hadway, Jeffrey Corsaut, Justin W. Hicks, Michael C. Langham, Felix W. Wehrli, Hidehiro Iida, Keith St Lawrence
Journal of Nuclear Medicine Dec 2021, 62 (12) 1789-1796; DOI: 10.2967/jnumed.120.260521

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A Noninvasive Method for Quantifying Cerebral Metabolic Rate of Oxygen by Hybrid PET/MRI: Validation in a Porcine Model
Lucas Narciso, Tracy Ssali, Linshan Liu, Heather Biernaski, John Butler, Laura Morrison, Jennifer Hadway, Jeffrey Corsaut, Justin W. Hicks, Michael C. Langham, Felix W. Wehrli, Hidehiro Iida, Keith St Lawrence
Journal of Nuclear Medicine Dec 2021, 62 (12) 1789-1796; DOI: 10.2967/jnumed.120.260521
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Keywords

  • cerebral blood flow
  • cerebral metabolic rate of oxygen
  • noninvasive PET
  • oxygen extraction fraction
  • PET/MRI
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