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Research ArticleClinical Investigation
Open Access

Simultaneous Mapping of Vasculature, Hypoxia, and Proliferation Using Dynamic Susceptibility Contrast MRI, 18F-FMISO PET, and 18F-FLT PET in Relation to Contrast Enhancement in Newly Diagnosed Glioblastoma

Solène Collet, Jean-Sébastien Guillamo, David Hassanein Berro, Ararat Chakhoyan, Jean-Marc Constans, Emmanuèle Lechapt-Zalcman, Jean-Michel Derlon, Mathieu Hatt, Dimitris Visvikis, Stéphane Guillouet, Cécile Perrio, Myriam Bernaudin and Samuel Valable
Journal of Nuclear Medicine October 2021, 62 (10) 1349-1356; DOI: https://doi.org/10.2967/jnumed.120.249524
Solène Collet
1Normandie University, UNICAEN, CEA, CNRS, ISTCT/CERVOxy Group, GIP Cyceron, Caen, France;
2Radiophysics Department, Centre François Baclesse, Caen, France;
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Jean-Sébastien Guillamo
1Normandie University, UNICAEN, CEA, CNRS, ISTCT/CERVOxy Group, GIP Cyceron, Caen, France;
3Department of Neurology, CHU de Caen, Caen, France;
4Department of Neurology, CHU de Nimes, Nimes, France;
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David Hassanein Berro
1Normandie University, UNICAEN, CEA, CNRS, ISTCT/CERVOxy Group, GIP Cyceron, Caen, France;
5Department of Neurosurgery, CHU de Caen, Caen, France;
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Ararat Chakhoyan
1Normandie University, UNICAEN, CEA, CNRS, ISTCT/CERVOxy Group, GIP Cyceron, Caen, France;
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Jean-Marc Constans
1Normandie University, UNICAEN, CEA, CNRS, ISTCT/CERVOxy Group, GIP Cyceron, Caen, France;
6Department of Neuroradiology, CHU de Caen, Caen, France;
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Emmanuèle Lechapt-Zalcman
1Normandie University, UNICAEN, CEA, CNRS, ISTCT/CERVOxy Group, GIP Cyceron, Caen, France;
7Department of Pathology, CHU de Caen, Caen, France;
8Department of Neuropathology, GHU Paris Psychiatry and Neuroscience, Paris, France;
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Jean-Michel Derlon
1Normandie University, UNICAEN, CEA, CNRS, ISTCT/CERVOxy Group, GIP Cyceron, Caen, France;
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Mathieu Hatt
9LaTIM, INSERM, UMR 1101, University of Brest, Brest, France; and
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Dimitris Visvikis
9LaTIM, INSERM, UMR 1101, University of Brest, Brest, France; and
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Stéphane Guillouet
10Normandie University, UNICAEN, CEA, CNRS, ISTCT/LDM-TEP Group, GIP Cyceron, Caen, France
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Cécile Perrio
10Normandie University, UNICAEN, CEA, CNRS, ISTCT/LDM-TEP Group, GIP Cyceron, Caen, France
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Myriam Bernaudin
1Normandie University, UNICAEN, CEA, CNRS, ISTCT/CERVOxy Group, GIP Cyceron, Caen, France;
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Samuel Valable
1Normandie University, UNICAEN, CEA, CNRS, ISTCT/CERVOxy Group, GIP Cyceron, Caen, France;
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Journal of Nuclear Medicine: 62 (10)
Journal of Nuclear Medicine
Vol. 62, Issue 10
October 1, 2021
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Simultaneous Mapping of Vasculature, Hypoxia, and Proliferation Using Dynamic Susceptibility Contrast MRI, 18F-FMISO PET, and 18F-FLT PET in Relation to Contrast Enhancement in Newly Diagnosed Glioblastoma
Solène Collet, Jean-Sébastien Guillamo, David Hassanein Berro, Ararat Chakhoyan, Jean-Marc Constans, Emmanuèle Lechapt-Zalcman, Jean-Michel Derlon, Mathieu Hatt, Dimitris Visvikis, Stéphane Guillouet, Cécile Perrio, Myriam Bernaudin, Samuel Valable
Journal of Nuclear Medicine Oct 2021, 62 (10) 1349-1356; DOI: 10.2967/jnumed.120.249524

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Simultaneous Mapping of Vasculature, Hypoxia, and Proliferation Using Dynamic Susceptibility Contrast MRI, 18F-FMISO PET, and 18F-FLT PET in Relation to Contrast Enhancement in Newly Diagnosed Glioblastoma
Solène Collet, Jean-Sébastien Guillamo, David Hassanein Berro, Ararat Chakhoyan, Jean-Marc Constans, Emmanuèle Lechapt-Zalcman, Jean-Michel Derlon, Mathieu Hatt, Dimitris Visvikis, Stéphane Guillouet, Cécile Perrio, Myriam Bernaudin, Samuel Valable
Journal of Nuclear Medicine Oct 2021, 62 (10) 1349-1356; DOI: 10.2967/jnumed.120.249524
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Keywords

  • proliferation
  • vasculature
  • hypoxia
  • MRI
  • PET
  • Glioblastoma
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