Effect of Tumor Perfusion and Receptor Density on Tumor Control Probability in 177Lu-DOTATATE Therapy: An In Silico Analysis for Standard and Optimized Treatment

Luis David Jiménez-Franco; Gerhard Glatting; Vikas Prasad; Wolfgang A. Weber; Ambros J. Beer; Peter Kletting

doi:10.2967/jnumed.120.245068

Research ArticleTheranostics

Effect of Tumor Perfusion and Receptor Density on Tumor Control Probability in ¹⁷⁷Lu-DOTATATE Therapy: An In Silico Analysis for Standard and Optimized Treatment

Luis David Jiménez-Franco, Gerhard Glatting, Vikas Prasad, Wolfgang A. Weber, Ambros J. Beer and Peter Kletting

Journal of Nuclear Medicine January 2021, 62 (1) 92-98; DOI: https://doi.org/10.2967/jnumed.120.245068

Luis David Jiménez-Franco

1ABX-CRO Advanced Pharmaceutical Services Forschungsgesellschaft mbH, Dresden, Germany

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Gerhard Glatting

2Department of Nuclear Medicine, Ulm University, Ulm, Germany

3Medical Radiation Physics, Department of Nuclear Medicine, Ulm University, Ulm, Germany; and

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Vikas Prasad

2Department of Nuclear Medicine, Ulm University, Ulm, Germany

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Wolfgang A. Weber

4Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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Ambros J. Beer

2Department of Nuclear Medicine, Ulm University, Ulm, Germany

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Peter Kletting

2Department of Nuclear Medicine, Ulm University, Ulm, Germany

3Medical Radiation Physics, Department of Nuclear Medicine, Ulm University, Ulm, Germany; and

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Journal of Nuclear Medicine

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January 1, 2021

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Effect of Tumor Perfusion and Receptor Density on Tumor Control Probability in ¹⁷⁷Lu-DOTATATE Therapy: An In Silico Analysis for Standard and Optimized Treatment

Luis David Jiménez-Franco, Gerhard Glatting, Vikas Prasad, Wolfgang A. Weber, Ambros J. Beer, Peter Kletting

Journal of Nuclear Medicine Jan 2021, 62 (1) 92-98; DOI: 10.2967/jnumed.120.245068

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Effect of Tumor Perfusion and Receptor Density on Tumor Control Probability in ¹⁷⁷Lu-DOTATATE Therapy: An In Silico Analysis for Standard and Optimized Treatment

Luis David Jiménez-Franco, Gerhard Glatting, Vikas Prasad, Wolfgang A. Weber, Ambros J. Beer, Peter Kletting

Journal of Nuclear Medicine Jan 2021, 62 (1) 92-98; DOI: 10.2967/jnumed.120.245068

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Keywords

minimal tumor perfusion
minimal receptor density
PBPK modeling
tumor control probability
177Lu-DOTATATE

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Effect of Tumor Perfusion and Receptor Density on Tumor Control Probability in ¹⁷⁷Lu-DOTATATE Therapy: An In Silico Analysis for Standard and Optimized Treatment

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