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Research ArticleNeurology

18F-FDG PET Imaging of the Inferior Colliculus in Asymmetric Hearing Loss

Iva Speck, Susan Arndt, Johannes Thurow, Ganna Blazhenets, Antje Aschendorff, Philipp T. Meyer and Lars Frings
Journal of Nuclear Medicine March 2020, 61 (3) 418-422; DOI: https://doi.org/10.2967/jnumed.119.231407
Iva Speck
1Department of Otorhinolaryngology–Head and Neck Surgery, Faculty of Medicine, University of Freiburg Medical Center, Freiburg, Germany; and
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Susan Arndt
1Department of Otorhinolaryngology–Head and Neck Surgery, Faculty of Medicine, University of Freiburg Medical Center, Freiburg, Germany; and
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Johannes Thurow
2Department of Nuclear Medicine, Faculty of Medicine, University of Freiburg Medical Center, Freiburg, Germany
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Ganna Blazhenets
2Department of Nuclear Medicine, Faculty of Medicine, University of Freiburg Medical Center, Freiburg, Germany
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Antje Aschendorff
1Department of Otorhinolaryngology–Head and Neck Surgery, Faculty of Medicine, University of Freiburg Medical Center, Freiburg, Germany; and
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Philipp T. Meyer
2Department of Nuclear Medicine, Faculty of Medicine, University of Freiburg Medical Center, Freiburg, Germany
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Lars Frings
2Department of Nuclear Medicine, Faculty of Medicine, University of Freiburg Medical Center, Freiburg, Germany
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  • FIGURE 1.
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    FIGURE 1.

    Axial 18F-FDG PET scans at level of PAC (top, VOI outline in blue) and IC (bottom) in 2 representative patients with left-sided (left image) and right-sided (right image) AHL. Arrows indicate side of decreased metabolism.

  • FIGURE 2.
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    FIGURE 2.

    Contralateral glucose metabolism was reduced in IC and in PAC, compared with ipsilateral side (P = 0.003 and P = 0.01, paired t tests). Shown are box plots (red) and individual values (other colors) of glucose metabolism of IC and PAC.

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    FIGURE 3.

    Longer duration of hearing impairment was associated with higher glucose metabolism of contralateral PAC (r2 = 0.33; P = 0.042).

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    TABLE 1

    Subjects’ Demographic and Audiometric Characteristics

    SubjectAge at scanning (y)SexImpaired sideVisually read asymmetry of metabolism on PETEtiology of AHLDuration of deafness (y)Bone conduction PTA4 (dB HL)Air conduction PTA4 (dB HL)Monosyllabic word recognition at 65 dB SPL (%)Brain stem evoked response audiometry (worse ear)Electrocochleography (worse ear)
    ICPACBetter earWorse earBetter earWorse earBetter earWorse earThreshold (dB)Interpeak latency (ms)Sum action potential (ms)Cochlear microphonic (dB HL)
    135.9MRRightward, moderateRightward, moderateSudden hearing loss1.52.50956.25>1301000904.3//
    247.8MRRightward, moderateRightward, mildMumps457.50>13016.25>1301000//n/d70
    340.9MRRightward, strongRightward, strongFracture of right petrous bone2.13.75>1307.5>1301000//n/d100
    452.4MLLeftward, strongLeftward, mildIntracochlear schwannoma1215>13015>1301000//n/d100
    575.8MRRightward, strongRightward, mildSudden hearing loss0.720>13038.75>130800//n/d90
    655.8FLLeftward, moderateLeftward, moderateSudden hearing loss0.86.25>13011.25>1301000n/dn/d0.190
    742.4MRRightward, moderateLeftward, mildMumps34053.752.5113.751000//n/d110
    840.0FLNo asymmetryLeftward, mildUnknown3132.5>13036.25>130900//n/d100
    960.1MRLeftward, mildRightward, mildSudden hearing loss2141.25113.7543.75113.75700//n/d100
    1058.0MLLeftward, mildRightward, mildMumps5325>13042.5>130450//n/d100
    1184.2MLLeftward, strongLeftward, mildSudden hearing loss0.535>13040>130700//n/d90
    1255.5FRNo asymmetryNo asymmetryPertussis4835>13040>130450////
    1317.9FLLeftward, strongLeftward, mildLarge aquaeductus vestibuli syndrome1512.5>13017.5>1301000//n/d100
    • HL = hearing loss; SPL = sound pressure level; PTA4 = pure tone average at frequencies 0.5, 1, 2, and 4 kHz; n/d = not derivable.

    • Slash indicates that test was not administered.

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Journal of Nuclear Medicine: 61 (3)
Journal of Nuclear Medicine
Vol. 61, Issue 3
March 1, 2020
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18F-FDG PET Imaging of the Inferior Colliculus in Asymmetric Hearing Loss
Iva Speck, Susan Arndt, Johannes Thurow, Ganna Blazhenets, Antje Aschendorff, Philipp T. Meyer, Lars Frings
Journal of Nuclear Medicine Mar 2020, 61 (3) 418-422; DOI: 10.2967/jnumed.119.231407

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18F-FDG PET Imaging of the Inferior Colliculus in Asymmetric Hearing Loss
Iva Speck, Susan Arndt, Johannes Thurow, Ganna Blazhenets, Antje Aschendorff, Philipp T. Meyer, Lars Frings
Journal of Nuclear Medicine Mar 2020, 61 (3) 418-422; DOI: 10.2967/jnumed.119.231407
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Keywords

  • 18F-FDG PET
  • brain stem nuclei
  • asymmetric hearing loss
  • cochlear implant
  • unilateral hearing loss
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