Article Figures & Data
Figures
- FIGURE 1.
Correlation of CXCR4-directed PET with MRI-determined lymphoma lesions. Depicted are representative MR images (T1c and FLAIR sequences) and corresponding CXCR4-directed PET images and fusion of MRI (FLAIR) and PET for 2 patients with primary CNSL (PCNSL) and secondary CNSL (SCNSL), respectively.
- FIGURE 2.
Ex vivo CXCR4 expression within lymphoma lesions. Shown is CXCR4 expression of CD20-positive lymphoma cells undergoing 68Ga-pentixafor imaging. (Top panel) Representative hematoxylin and eosin (HE) stains of 4 CNSL patients; embedded are PET images of corresponding patients. (Middle panel) Immunohistochemistry for lymphoma-specific CD20 marker. (Bottom panel) Immunohistochemistry for CXCR4 in corresponding lymphoma samples.
- FIGURE 3.
CXCR4-directed PET prediction of treatment response. Depicted are correlations between η and properties extracted from pretreatment scans: V(T1c) in MRI (A and E), V(PET) (B), max(PET) (C), and ∫(PET) (D and F). A–D depict results from lesion-based approach. Each dot represents 1 of 14 diagnosed lymphoma lesions. In E and F, results from patient-based approach are shown. Each dot represents results from 1 of 7 patients. Pearson correlation coefficient (c) and P value are reported inside each plot. Least-squares regression line is shown in black.
Tables
Patient Sex Age (y) Diagnosis Disease stage No. of relapses 1 M 50 PCNSL First diagnosis 0 2 M 67 PCNSL First diagnosis 0 3 F 63 DLBCL CNS relapse 3 4 F 55 DLBCL CNS relapse 1 5 F 65 PCNSL First diagnosis 0 6 M 80 PCNSL First diagnosis 0 7 M 59 PCNSL First diagnosis 0 8 M 66 PCNSL First diagnosis 0 9 M 58 PCNSL First diagnosis 0 10 M 64 PCNSL First diagnosis 0 11 M 79 DLBCL CNS relapse 1 PCNSL = primary CNSL; DLBCL = diffuse large B-cell lymphoma.
Patient SUVmax SUVmean Tumor Background Ratio Tumor Background Ratio 1 No lesion No lesion No lesion No lesion No lesion No lesion 2 4.2 0.2 18.3 2.8 0.2 17.3 3 23.3 0.6 38.8 16.1 0.5 32.2 4 5.5 0.3 16.2 3.2 0.2 16.2 5 7.0 0.4 18.4 4.5 0.2 19.6 6 4.7 0.4 13.4 3.1 0.2 18.2 7 6.0 0.1 75.1 4.0 0.01 201.0 8 10.1 0.8 13.2 5.6 0.2 30.9 9 8.3 0.1 83.0 5.4 0.1 54.0 10 4.6 0.2 23.0 3.2 0.2 15.9 11 5.4 0.3 21.6 3.4 0.2 21.2
Supplemental Data
Files in this Data Supplement:
