Brain Tau Imaging: Food and Drug Administration Approval of ¹⁸F-Flortaucipir Injection

Examples of negative and positive ¹⁸F-flortaucipir scans. Uptake of ¹⁸F-flortaucipir in neocortical gray matter regions only was assessed. (A) Example of negative scan with absence of neocortical activity; off-target binding is noted in choroid plexus and brain stem nuclei. (B) Example of positive scan showing increased neocortical activity in medial prefrontal and cingulate, lateral prefrontal, parietal, occipital, and precuneus regions.