Multiparametric 18F-FDG PET/MRI of the Breast: Are There Differences in Imaging Biomarkers of Contralateral Healthy Tissue Between Patients With and Without Breast Cancer?

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FIGURE 1.
A 50-y-old postmenopausal woman with fibroadenoma (arrows) in left breast. (A) Unenhanced fat-saturated T1-weighted MRI shows extreme amount of FGT (ACR d). (B) Moderate BPE is seen on dynamic contrast-enhanced MRI at 90 s. (C) Mean ADC of breast parenchyma of contralateral breast on diffusion-weighted imaging with ADC mapping is 1.5 × 10⁻³ mm²/s. (D) On ¹⁸F-FDG PET/CT, lesion is not ¹⁸F-FDG–avid, and BPU of normal breast parenchyma is relatively high, with SUV_max of 3.2.
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FIGURE 2.
Mucinous carcinoma (arrows) in right breast in 42-y-old premenopausal woman. (A) Precontrast fat-saturated T1-weighted MR images show extreme amount of FGT (ACR d). (B) BPE in dynamic contrast-enhanced MRI at 90 s is mild. (C) On diffusion-weighted imaging, ADCs of normal breast parenchyma are 2.17 × 10⁻³ mm²/s. (D) SUV_max (BPU) in ¹⁸F-FDG PET/CT is 2.58.

TABLE 1

ACR Classification for BPE and FGT by Both Readers

TABLE 2

Inter- and Intrareader Agreement of Parameters of Healthy Contralateral Breast

Agreement	Concordance correlation coefficient
Intrareader BPU	0.956 (0.942, 0.970)
Interreader BPU	0.949 (0.932, 0.965)
Interreader BPE	0.907 (0.878, 0.937)
Interreader FGT	0.933 (0.911, 0.954)
Interreader mean ADC	0.677 (0.587, 0.766)