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Journal of Nuclear Medicine

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Meeting ReportOncology: Clinical Therapy and Diagnosis

Interim results of a Phase I/II prospective dose escalation trial evaluating safety and efficacy of combination 177Lu PSMA 617 and NOX66 in men with mCRPC post androgen signalling inhibition and 2 lines of taxane chemotherapy (LuPIN trial).

Louise Emmett, Megan Crumbaker, Andrew Nguyen, Bao Ho, Charlotte Yin, Noah Isheish, Arun Azad, John Violet, Shikha Sharma and Anthony Joshua
Journal of Nuclear Medicine May 2019, 60 (supplement 1) 465;
Louise Emmett
3390 Victoria St St Vincent's Hospital Sydney Australia
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Megan Crumbaker
3390 Victoria St St Vincent's Hospital Sydney Australia
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Andrew Nguyen
3390 Victoria St St Vincent's Hospital Sydney Australia
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Bao Ho
3390 Victoria St St Vincent's Hospital Sydney Australia
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Charlotte Yin
3390 Victoria St St Vincent's Hospital Sydney Australia
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Noah Isheish
3390 Victoria St St Vincent's Hospital Sydney Australia
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Arun Azad
1Oncology Monash University Melbourne Australia
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John Violet
2Radiation Oncology Peter MacCallum Cancer Centre Melbourne Australia
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Shikha Sharma
3390 Victoria St St Vincent's Hospital Sydney Australia
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Anthony Joshua
3390 Victoria St St Vincent's Hospital Sydney Australia
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Tables

  • Cohort 1 (n=8)Cohort 2 (n=8)Overall
    PSA response (>50%) reduction5/8 (62.5%)6/8 (75%)11/16 (69%)
    AEs ≥ grade II • Haematologic • Fatigue • Other (pneumonitis)4/8 (37.5%) 3/8 3/8 1/81/8 (12.5%) - 1/8 -5/16 (31%)
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Journal of Nuclear Medicine
Vol. 60, Issue supplement 1
May 1, 2019
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Interim results of a Phase I/II prospective dose escalation trial evaluating safety and efficacy of combination 177Lu PSMA 617 and NOX66 in men with mCRPC post androgen signalling inhibition and 2 lines of taxane chemotherapy (LuPIN trial).
Louise Emmett, Megan Crumbaker, Andrew Nguyen, Bao Ho, Charlotte Yin, Noah Isheish, Arun Azad, John Violet, Shikha Sharma, Anthony Joshua
Journal of Nuclear Medicine May 2019, 60 (supplement 1) 465;

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Interim results of a Phase I/II prospective dose escalation trial evaluating safety and efficacy of combination 177Lu PSMA 617 and NOX66 in men with mCRPC post androgen signalling inhibition and 2 lines of taxane chemotherapy (LuPIN trial).
Louise Emmett, Megan Crumbaker, Andrew Nguyen, Bao Ho, Charlotte Yin, Noah Isheish, Arun Azad, John Violet, Shikha Sharma, Anthony Joshua
Journal of Nuclear Medicine May 2019, 60 (supplement 1) 465;
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Oncology: Clinical Therapy and Diagnosis

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