Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Corporate & Special Sales
    • Journal Claims
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Permissions
    • Advertisers
    • Continuing Education
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Corporate & Special Sales
    • Journal Claims
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Permissions
    • Advertisers
    • Continuing Education
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • Follow JNM on Twitter
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Subscribe to our RSS feeds
Meeting ReportOncology: Clinical Therapy and Diagnosis

Added value of single photon emission computed tomography (SPECT) / Computed Tomography (CT) with radioiodine whole body scan in follow up of patients with differentiated thyroid cancer

Hatem Nasr, Ayed Alaklubi, Abdullah Alqarni and Hussien Farghaly
Journal of Nuclear Medicine May 2020, 61 (supplement 1) 490a;
Hatem Nasr
1Nuclear Medicine Cairo University Hospital Cairo Egypt
2Radiology Prince Sultan Military Medical City Riyadh Saudi Arabia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ayed Alaklubi
2Radiology Prince Sultan Military Medical City Riyadh Saudi Arabia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Abdullah Alqarni
2Radiology Prince Sultan Military Medical City Riyadh Saudi Arabia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hussien Farghaly
3Nuclear Medicine Assuit University Hospital Assuit Egypt
2Radiology Prince Sultan Military Medical City Riyadh Saudi Arabia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

490a

Aim: To evaluate the added value of single-photon emission computerized tomography/computerized tomography (SPECT/CT) in whole body radioiodine (WBI) scan in patients with differentiated thyroid cancer.

Material and Methods: All patients who underwent WBI scan with SPECT/CT from October 2016 to May 2018 were consecutively included. The study included 48 patients (average age of 46.9±18.7 years; 30 females). Data collected included patients’ demographics, TSH levels, TG and TG antibodies level, prior radioiodine ablation, surgical and histopathological findings as well as planer and SPECT/CT findings. Findings other than obvious physiological uptake were interpreted as positive, negative or equivocal in thyroid bed (TB), cervical lymph nodes (LN) or distant metastases (DM). For positive-negative classification, equivocal results were included with the negative group. We used Student T-test to compare mean values of continuous variables between study groups. Fissure Exact test was used to compare the frequency of added SPECT/CT findings between study groups based on TG level or age. The cutoff for TG and age that best differentiate positive from negative scans was set based on ROC analysis. Pearson correlation was used to assess the relationship between number of SPECT/CT added lesions and TG level or age. Logistic regression was used to detect independent predictors of SPECT/CT additional lesions.

Results: The study population included 43 papillary, 4 follicular and 1 hurthel cell carcinoma. Sixteen patients (33.3%) had at least one prior ablative dose of I-131. WBI scans included 15 I-123 scan and 33 I-131 post ablation scan. Thyrogen preparation was used in 26 (54%) patients. Based on both the planar and SPECT/CT images there were 43 (89.6%) positive patients and 5 (10.4%) negative patients. Positive patients included 38 with TB uptake, 18 with LN uptake and 12 with DM. SPECT/CT was able to detect or confirm additional 47 lesions (4 in TB, 22 LN and 21 DM) in 20 patients. Patients group with SPECT/CT added lesions had higher mean serum TG level (1190.5±1872.9 vs 46.8±225.4; p<0.001) and patients age (58.3±16.9 vs 38.8±15.6; p<0.001). Both TG and age were positively correlated to number of SPECT/CT added lesions (0.601; p<0.0001 and 0.375; p=0.009 respectively). Cutoff values of ˃3.4 ng/ml for TG and >45 years old for age were the best to predict additional lesions on SPECT/CT with odds ratio of 43.6 and 6.6 respectively and sensitivity, specificity, PPV, NPP and accuracy of 95, 75, 73.1, 95.5 & 87.5% (p<0.0001) and 80, 71.4, 66.7, 83.3 & 75% (p=0.001) respectively. Adding SPECT/CT reduced equivocal results by accurate localization of uptake sites, differentiating lymph nodes from thyroid bed uptake and detecting false positive due to underlying unexpected physiological uptake. Adding the SPECT/CT to planar imaging decreased equivocal results by 87% from 54 (2 TB, 33 LN and 19 DM) to only 7 (5 LN and 2 DM) and achieved definitive diagnosis in 41/48 patients (85.4%). Conclusion: Adding SPECT/CT to WBI scan detected new lesions and significantly reduced equivocal results by either confirming or excluding the presence of LN involvement or DM, decreased false positive results due to unexpected physiological uptake and achieved definitive results in most studies. Addition of SPECT/CT could particularly be more useful in patients with serum TG >3.4 and/or >45 years of age.

Previous
Back to top

In this issue

Journal of Nuclear Medicine
Vol. 61, Issue supplement 1
May 1, 2020
  • Table of Contents
  • Index by author
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Added value of single photon emission computed tomography (SPECT) / Computed Tomography (CT) with radioiodine whole body scan in follow up of patients with differentiated thyroid cancer
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
Added value of single photon emission computed tomography (SPECT) / Computed Tomography (CT) with radioiodine whole body scan in follow up of patients with differentiated thyroid cancer
Hatem Nasr, Ayed Alaklubi, Abdullah Alqarni, Hussien Farghaly
Journal of Nuclear Medicine May 2020, 61 (supplement 1) 490a;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Added value of single photon emission computed tomography (SPECT) / Computed Tomography (CT) with radioiodine whole body scan in follow up of patients with differentiated thyroid cancer
Hatem Nasr, Ayed Alaklubi, Abdullah Alqarni, Hussien Farghaly
Journal of Nuclear Medicine May 2020, 61 (supplement 1) 490a;
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Info & Metrics

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

Oncology: Clinical Therapy and Diagnosis

  • The association between BRAF V600E mutation of lymph node metastasis and its invasive characteristics in thyroid papillary carcinomas
  • Sequential occurrence of paraganglioma in abdomen, neck and head demonstrated by serial Ga68-DOTANOC PET-CT
Show more Oncology: Clinical Therapy and Diagnosis

Head and Neck

  • Prognostic value of per-site metabolic tumor volume on FDG PET in patients with differentiated thyroid cancer before radioactive iodine therapy
  • Evaluating the role of partial-volume correction in predicting survival in head and neck cancer
  • F-18 FDG uptake predicts progression-free and overall survival in patients with nonmetastatic human papillomavirus-related oropharyngeal squamous cell carcinoma
Show more Head and Neck

Similar Articles

SNMMI

© 2022 Journal of Nuclear Medicine

Powered by HighWire