Article Figures & Data
Figures
- FIGURE 1.
Kaplan–Meier curves of PFS (A) and OS (B).
- FIGURE 2.
Kaplan–Meier curves of OS after resection of primary tumor and OS per primary tumor location. Median OS is 43 and 65 mo without and with resection, respectively. Median OS is 67 mo for small-intestine NETs, 51 mo for large intestine, 41 mo for lung, 50 mo for pancreas, 59 mo for cancer of unknown primary (CUP), and 52 mo for other NETs.
- FIGURE 3.
Kaplan–Meier curves of OS per Ki-67 and CgA quartiles and performance status classes. Median OS is 74 mo for Ki-67 < 2%, 54 mo for 2%–5%, 56 mo for 5%–10%, and 32 mo for >10%. Median OS is 86 mo for CgA < 112, 61 mo for 112–336, 54 mo for 336–1,168, and 35 mo for >1,168. Median OS is 64 mo for WHO 0, 41 mo for WHO 1, and 37 mo for WHO 2/3.
Tables
Variable Characteristic Data Sex Male 444 (56.8%) Female 338 (43.2%) Age (y) 60.3 ± 11.0 (22–83) Location of primary tumor (n = 782) Small intestine 221 (28.3%) Large intestine 42 (5.4%) Lung 60 (7.7%) Pancreas 277 (35.4%) Unknown primary 106 (13.6%) Other 76 (9.7%) Tumor grade (n = 570) Grade 1 182 (31.9%) Grade 2 345 (60.5%) Grade 3 43 (7.5%) Ki-67 (n = 503) Q1 ≤2% Q2 3%–5% Q3 6%–10% Q4 >10% Functional tumor (n = 555) Yes 280 (50.5%) No 275 (49.5%) Performance status (n = 782) WHO 0 547 (69.9%) WHO 1 190 (24.3%) WHO 2–3 45 (5.8%) Comorbidities Hypertension (n = 239) 99 (41.4%) Diabetes (n = 782) 46 (5.9%) Prior treatment Interferon-α (n = 727) 36 (5.0%) Chemotherapy (n = 727) 159 (21.9%) Resection, primary tumor (n = 710) 336 (47.3%) Ablation (n = 727) 100 (13.8%) Radiotherapy (n = 727) 35 (4.8%) Somatostatin analog (n = 727) 297 (40.9%) Isotope (n = 782) 177Lu 295 (37.7%) 90Y 96 (12.3%) 177Lu and 90Y 391 (50.0%) PRRT administrations (n = 782) 3 395 (50.4%) 4 329 (42.1%) 5–6 59 (7.5%) Cumulative activity (GBq) (n = 782) 177Lu 21.7 (13.3–36.7) 90Y 11.5 (4.8–23.6) 177Lu and 90Y 18.2 (5.0–33.7) Blood count (n = 782) Normal 546 (69.8%) CgA (n = 661) Q1 <112 Q2 112–333 Q3 336–1,168 Q4 >1,168 Serotonin (n = 627) 273 (10–14,200) eGFR (n = 778) 81.2 (30.56–259.08) Creatinine (n = 778) 75.0 (27–186) Continuous data are mean ± SD followed by range. Categoric data are number followed by percentage. When variables are divided into quartiles, range of quartile is given. Percentages may not add up to 100% due to rounding.
Univariate Multivariate Parameter Group HR 95% CI P HR 95% CI P Ki-67 Q1: <2% 1 0.002 1 0.044 Q2: 2%–5% 1.165 0.898–1.513 1.171 0.880–1.557 Q3: 5%–10% 1.466 1.111–1.934 1.419 1.041–1.935 Q4: >10% 1.631 1.230–2.163 1.493 1.090–2.045 Comorbidities Diabetes 1.373 0.989–1.907 0.058† 1.706 1.117–2.605 0.013 Prior treatment Chemotherapy 1.362 1.123–1.652 0.002† 1.375 1.039–1.820 0.026 Interferon-α 1.487 1.046–2.114 0.027 2.054 1.211–3.485 0.008 CgA (μg/L) Q1: <112 1 <0.001 1 <0.001 Q2: 112–333 1.189 0.932–1.517 1.267 0.922–1.741 Q3: 336–1,168 1.580 1.241–2.011 1.469 1.084–1.992 Q4: >1,168 2.148 1.679–2.747 2.039 1.488–2.794 HR > 1 indicates greater risk for disease progression compared with reference value (HR = 1).
Median OS (mo) Univariate Cox regression analysis Location of primary Resected Unresected HR 95% CI P Small intestine 77 (37–134) 48 (32–90) 0.649 0.423–0.995 0.047* Large intestine 51 (28–∞) 45 (24–61) 0.625 0.257–1.522 0.301 Lung 51 (26–67) 41 (31–45) 0.755 0.374–1.522 0.432 Pancreas 65 (35–112) 43 (24–69) 0.595 0.426–0.832 0.002* Overall 64 (32–112) 47 (29–80) 0.715 0.584–0.877 0.001* ↵* Significant.
Data in parentheses are IQR.
Univariate Multivariate Parameter Group HR 95% CI P HR 95% CI P Ki-67 Q1: <2% 1 0.001 1 0.014 Q2: 2%–5% 1.340 0.960–1.871 1.363 0.946–1.965 Q3: 5%–10% 1.519 1.051–2.194 1.203 0.798–1.814 Q4: >10% 2.143 1.488–3.087 1.930 1.285–2.899 Performance status WHO 0 1 <0.001 1 0.010 WHO 1 1.781 1.432–2.214 1.551 1.109–2.169 WHO 2–3 2.817 1.941–4.089 2.305 1.432–3.713 Prior treatment Ablation 1.458 1.103–1.928 0.008 1.519 1.041–2.215 0.030 Chemotherapy 1.792 1.434–2.239 <0.001 1.979 1.412–2.773 <0.001 CgA (μg/L) Q1: <112 1 <0.001 1 <0.001 Q2: 112–336 1.531 1.100–2.131 1.690 1.095–2.608 Q3: 336–1,168 1.887 1.354–2.631 1.816 1.718–2.799 Q4: >1,168 3.357 2.434–4.631 2.671 1.717–4.155 HR > 1 indicates greater risk for death of any cause and HR < 1 lower risk.
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