Article Figures & Data
Figures
- FIGURE 1.
Time line of crossover trial.
- FIGURE 2.
Quantitative analysis of kidney and pancreatic uptake of 111In-labeled exendin-4 in SPECT/CT scans. SPECT/CT images (A, B, D, and E) were obtained 24 h after 111In-exendin injection, coinfused with saline (A and B) or Gelofusine (D and E). In 3 of 10 patients, 3-dimensional projections of SPECT images (C and F) demonstrated that pancreas could be more clearly discriminated from kidney signal after Gelofusine injection (arrows) (F). Kidney uptake of 111In-labeled exendin-4 was significantly reduced after administration of Gelofusine (G), whereas activity concentration in pancreas remained same (H). Clearance of 111In-labeled exendin-4 was determined in urine (I) and in blood (J). *P < 0.05. **P < 0.01. ID = injected dose.
Tables
Parameter Low kidney uptake High kidney uptake Patient 1 Patient 2 Patient 3 Patient 4 Patient 5 Patient 1 Patient 2 Patient 3 Patient 4 Patient 5 M F M F M F M F M F M F M F M F M F M F TIAC insulinoma (h) 0.44 0.44 0.81 0.81 0.65 0.65 0.62 0.62 0.96 0.96 0.44 0.44 0.81 0.81 0.65 0.65 0.62 0.62 0.96 0.96 Kidney dose (Gy) 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 Without Gelofusine Max. inj. activity (GBq) 1.79 1.64 1.79 1.64 1.79 1.64 1.79 1.64 1.79 1.64 1.12 1.04 1.12 1.04 1.12 1.04 1.12 1.04 1.12 1.04 Insulinoma dose (Gy) 127.8 117.4 54.2 48.0 90 82.7 78.5 72.2 112.2 103.1 80.2 74.1 32.9 30.3 56.5 52.2 49.3 45.5 70.7 65.1 Islet dose (Gy) 4.0 4.8 4.0 4.8 4.0 4.8 4.0 4.8 4.0 4.8 2.6 3.0 2.6 3.0 2.6 3.0 2.6 3.0 2.6 3.0 With Gelofusine Max. inj. activity (GBq) 2.18 2.01 2.18 2.01 2.18 2.01 2.18 2.01 2.18 2.01 1.38 1.26 1.38 1.26 1.38 1.26 1.38 1.26 1.38 1.26 Insulinoma dose (Gy) 156.1 143.6 63.8 58.7 109.9 101.1 95.9 88.2 137.0 126.0 98.5 90.2 40.2 36.9 69.3 63.5 60.5 55.4 86.4 79.2 Islet dose (Gy) 4.9 5.8 4.9 5.8 4.9 5.8 4.9 5.8 4.9 5.8 3.1 3.7 3.1 3.7 3.1 3.7 3.1 3.7 3.1 3.7 Max. inj. = maximum injected.
Input parameters for model: islet size, 400 μm; percentage of islets in pancreas, 2%.
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