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Meeting ReportOncology, Clinical Diagnosis Track

Quantification of Colorectal Liver Metastases using FDG PET Volumetric and Heterogeneity Features for Improved Prediction of Clinical Outcome

Arman Rahmim, Kirstine Bak-Fredslund, Saeed Ashrafinia, Charles Schmidtlein, Rathan Subramaniam, Anni Morsing, Susanne Keiding, Jacob Horsager and Ole Munk
Journal of Nuclear Medicine May 2018, 59 (supplement 1) 350;
Arman Rahmim
2Department of Radiology Johns Hopkins University Baltimore MD United States
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Kirstine Bak-Fredslund
1Department of Nuclear Medicine & PET Center Aarhus University Hospital Aarhus Denmark
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Saeed Ashrafinia
2Department of Radiology Johns Hopkins University Baltimore MD United States
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Charles Schmidtlein
3Department of Medical Physics Memorial Sloan-Kettering Cancer Center New York NY United States
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Rathan Subramaniam
4Department of Radiology University of Texas Southwestern Medical Center Dallas TX United States
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Anni Morsing
1Department of Nuclear Medicine & PET Center Aarhus University Hospital Aarhus Denmark
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Susanne Keiding
1Department of Nuclear Medicine & PET Center Aarhus University Hospital Aarhus Denmark
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Jacob Horsager
1Department of Nuclear Medicine & PET Center Aarhus University Hospital Aarhus Denmark
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Ole Munk
1Department of Nuclear Medicine & PET Center Aarhus University Hospital Aarhus Denmark
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  • Table 1: Univariate Cox regression ([asterisk] indicates significance after correction for multiple testing)

    OSPFSEFS
    ParametersHR (95% CI)p-valueHR (95% CI)p-valueHR (95% CI)p-value
    Num. of liver mets2.71 (1.44-5.12)0.0021[asterisk]2.61 (1.18-5.79)0.0182.42 (1.32-4.42)0.0042
    MTV2.62 (1.38-4.98)0.0034[asterisk]1.96 (0.87-4.41)0.112.29 (1.23-4.24)0.0086
    TLG2.62 (1.38-4.98)0.0034[asterisk]1.96 (0.87-4.41)0.112.29 (1.23-4.24)0.0086
    SUVpeak2.05 (1.09-3.86)
  • Table 2: Final multivariate Cox regression model for OS, PFS and EFS

    Survival AnalysisMetrics in the modelHR(95% CI)p-value
    OSMTV,Num. of liver mets3.34(1.68-6.65)0.0006
    PFSheterogeneity features (described in figure caption): V10-90,Histogram COV,V904.42(1.82-10.7)0.0010
    EFSMTV,Num. of liver mets2.69(1.42-5.11)0.0024
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Journal of Nuclear Medicine
Vol. 59, Issue supplement 1
May 1, 2018
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Quantification of Colorectal Liver Metastases using FDG PET Volumetric and Heterogeneity Features for Improved Prediction of Clinical Outcome
Arman Rahmim, Kirstine Bak-Fredslund, Saeed Ashrafinia, Charles Schmidtlein, Rathan Subramaniam, Anni Morsing, Susanne Keiding, Jacob Horsager, Ole Munk
Journal of Nuclear Medicine May 2018, 59 (supplement 1) 350;

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Quantification of Colorectal Liver Metastases using FDG PET Volumetric and Heterogeneity Features for Improved Prediction of Clinical Outcome
Arman Rahmim, Kirstine Bak-Fredslund, Saeed Ashrafinia, Charles Schmidtlein, Rathan Subramaniam, Anni Morsing, Susanne Keiding, Jacob Horsager, Ole Munk
Journal of Nuclear Medicine May 2018, 59 (supplement 1) 350;
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