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Journal of Nuclear Medicine

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Research ArticleTheranostics

PSMA-11–Derived Dual-Labeled PSMA Inhibitors for Preoperative PET Imaging and Precise Fluorescence-Guided Surgery of Prostate Cancer

Ann-Christin Baranski, Martin Schäfer, Ulrike Bauder-Wüst, Mareike Roscher, Jana Schmidt, Esther Stenau, Tobias Simpfendörfer, Dogu Teber, Lena Maier-Hein, Boris Hadaschik, Uwe Haberkorn, Matthias Eder and Klaus Kopka
Journal of Nuclear Medicine April 2018, 59 (4) 639-645; DOI: https://doi.org/10.2967/jnumed.117.201293
Ann-Christin Baranski
1Division of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Martin Schäfer
1Division of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Ulrike Bauder-Wüst
1Division of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Mareike Roscher
1Division of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Jana Schmidt
1Division of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Esther Stenau
2Division of Computer-Assisted Medical Interventions (CAMI), German Cancer Research Center (DKFZ), Heidelberg, Germany
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Tobias Simpfendörfer
3Department of Urology, Heidelberg University Hospital, Heidelberg, Germany
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Dogu Teber
3Department of Urology, Heidelberg University Hospital, Heidelberg, Germany
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Lena Maier-Hein
2Division of Computer-Assisted Medical Interventions (CAMI), German Cancer Research Center (DKFZ), Heidelberg, Germany
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Boris Hadaschik
4Department of Urology, University Hospital Essen, Essen, Germany
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Uwe Haberkorn
5Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany
6Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), Heidelberg, Germany
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Matthias Eder
7Division of Radiopharmaceutical Development, German Cancer Consortium (DKTK), partner site Freiburg, and Department of Nuclear Medicine, University Medical Center, Freiburg, Germany; and
8German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
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Klaus Kopka
1Division of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Heidelberg, Germany
8German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
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Journal of Nuclear Medicine: 59 (4)
Journal of Nuclear Medicine
Vol. 59, Issue 4
April 1, 2018
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PSMA-11–Derived Dual-Labeled PSMA Inhibitors for Preoperative PET Imaging and Precise Fluorescence-Guided Surgery of Prostate Cancer
Ann-Christin Baranski, Martin Schäfer, Ulrike Bauder-Wüst, Mareike Roscher, Jana Schmidt, Esther Stenau, Tobias Simpfendörfer, Dogu Teber, Lena Maier-Hein, Boris Hadaschik, Uwe Haberkorn, Matthias Eder, Klaus Kopka
Journal of Nuclear Medicine Apr 2018, 59 (4) 639-645; DOI: 10.2967/jnumed.117.201293

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PSMA-11–Derived Dual-Labeled PSMA Inhibitors for Preoperative PET Imaging and Precise Fluorescence-Guided Surgery of Prostate Cancer
Ann-Christin Baranski, Martin Schäfer, Ulrike Bauder-Wüst, Mareike Roscher, Jana Schmidt, Esther Stenau, Tobias Simpfendörfer, Dogu Teber, Lena Maier-Hein, Boris Hadaschik, Uwe Haberkorn, Matthias Eder, Klaus Kopka
Journal of Nuclear Medicine Apr 2018, 59 (4) 639-645; DOI: 10.2967/jnumed.117.201293
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Cited By...

  • Identification of alternative protein targets of glutamate-ureido-lysine associated with PSMA tracer uptake in prostate cancer cells
  • Rational Linker Design to Accelerate Excretion and Reduce Background Uptake of Peptidomimetic PSMA-Targeting Hybrid Molecules
  • Cytoplasmic Localization of Prostate-Specific Membrane Antigen Inhibitors May Confer Advantages for Targeted Cancer Therapies
  • Hybrid Tracers Based on Cyanine Backbones Targeting Prostate-Specific Membrane Antigen: Tuning Pharmacokinetic Properties and Exploring Dye-Protein Interaction
  • Trending: Radioactive and Fluorescent Bimodal/Hybrid Tracers as Multiplexing Solutions for Surgical Guidance
  • Prostate-Specific Membrane Antigen-Guided Surgery
  • A Dual-Modality Linker Enables Site-Specific Conjugation of Antibody Fragments for 18F-Immuno-PET and Fluorescence Imaging
  • New Developments in Dual-Labeled Molecular Imaging Agents
  • Entering the Era of Molecularly Targeted Precision Surgery in Recurrent Prostate Cancer
  • Synthesis and Preclinical Characterization of the PSMA-Targeted Hybrid Tracer PSMA-I&F for Nuclear and Fluorescence Imaging of Prostate Cancer
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Theranostics

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  • Evidence-Based Clinical Protocols to Monitor Efficacy of [177Lu]Lu-PSMA Radiopharmaceutical Therapy in Metastatic Castration-Resistant Prostate Cancer Using Real-World Data
  • 177Lu-Labeled Anticlaudin 6 Monoclonal Antibody for Targeted Therapy in Esophageal Cancer
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Basic

  • Dopamine D1 Receptor Agonist PET Tracer Development: Assessment in Nonhuman Primates
  • Optical Navigation of the Drop-In γ-Probe as a Means to Strengthen the Connection Between Robot-Assisted and Radioguided Surgery
  • Synthesis and Preclinical Evaluation of a 68Ga-Labeled Adnectin, 68Ga-BMS-986192, as a PET Agent for Imaging PD-L1 Expression
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Keywords

  • fluorescence-guided surgery
  • PET imaging
  • prostate cancer
  • PSMA-11
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