Research ArticleNeurology

Neuroinflammation Appears Early on PET Imaging and Then Plateaus in a Mouse Model of Alzheimer Disease

Francisco R. López-Picón, Anniina Snellman, Olli Eskola, Semi Helin, Olof Solin, Merja Haaparanta-Solin and Juha O. Rinne
Journal of Nuclear Medicine March 2018, 59 (3) 509-515; DOI: https://doi.org/10.2967/jnumed.117.197608

Article Figures & Data

Figures

  • FIGURE 1.
    FIGURE 1.

    (A) In vivo PET images of 11C-PIB in 26-mo-old transgenic (TG) and WT APP23 mice. (B–E) Ratios of FC (B), PTC (C), hippocampus (HIPPO) (D), and thalamus (THA) (E) to cerebellum (CB) from 17 to 26 mo of age. Dotted line separates data of pilot study from data of longitudinal study (n = 32). *P < 0.05. **P < 0.01. ***P < 0.001.

  • FIGURE 2.
    FIGURE 2.

    (A) In vivo PET images of 18F-GE-180 in 26-mo-old transgenic (TG) and WT APP23 mice. (B–E) Ratios of FC (B), PTC (C), hippocampus (HIPPO) (D), and thalamus (THA) (E) to cerebellum (CB) from 17 to 26 mo of age. Dotted line separates data of pilot study from data of longitudinal study (n = 30). *P < 0.05. **P < 0.01. ***P < 0.001.

  • FIGURE 3.
    FIGURE 3.

    Correlation of the ratios of FC (A), PTC (B), hippocampus (HIPPO) (C), and thalamus (THA) (D) to cerebellum (CB) between 11C-PIB and 18F-GE-180 in transgenic APP23 mice from 17 to 26 mo of age, calculated with Pearson correlation (n = 17).

  • FIGURE 4.
    FIGURE 4.

    (A) Representative ex vivo autoradiography images of 11C-PIB binding in 26-mo-old transgenic (TG) and WT APP23 mice together with Aβ40-immunostaining (A). (B) Ratios of FC, PTC, hippocampus (HIPPO), and thalamus (THA) to cerebellum (CB). **P < 0.01. ***P < 0.001.

  • FIGURE 5.
    FIGURE 5.

    (A) Representative ex vivo brain autoradiography images of 18F-GE-180 binding in 26-mo-old transgenic (TG) and WT APP23 mice together with Iba1 immunostaining. (B) Ratios of FC, PTC, hippocampus (HIPPO), and thalamus (THA) to cerebellum (CB). *P < 0.05. **P < 0.01.

Tables

  • TABLE 1

    Ratio and Percentage Increase from 17 to 20, 23, and 26 Months in APP23 Transgenic Mice

    11C-PIB18F-GE-180
    Site17–20 mo17–23 mo17–26 mo17–20 mo17–23 mo17–26 mo
    FC/CB0.64 (52%)1.03 (84%)1.72 (140%)0.00 (0%)0.01 (1%)0.02 (2%)
    PTC/CB0.56 (50%)0.83 (75%)1.13 (102%)0.06 (8%)0.08 (10%)0.11 (14%)
    HIPPO/CB0.33 (30%)0.70 (65%)1.07 (100%)0.03 (3%)0.04 (4%)0.01 (1%)
    THA/CB0.16 (17%)0.24 (25%)0.77 (82%)0.03 (4%)0.10 (14%)0.16 (23%)

    • CB = cerebellum; HIPPO = hippocampus; THA = thalamus.

Additional Files

Back to top

In this issue

Print
Download PDF
Article Alerts
Email Article
Citation Tools
Bookmark this article

Jump to section

Keywords