Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

Silvio R. Meier; Stina Syvänen; Greta Hultqvist; Xiaotian T. Fang; Sahar Roshanbin; Lars Lannfelt; Ulf Neumann; Dag Sehlin

doi:10.2967/jnumed.118.213140

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Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

Silvio R. Meier, Stina Syvänen, Greta Hultqvist, Xiaotian T. Fang, Sahar Roshanbin, Lars Lannfelt, Ulf Neumann and Dag Sehlin

Journal of Nuclear Medicine December 2018, 59 (12) 1885-1891; DOI: https://doi.org/10.2967/jnumed.118.213140

Silvio R. Meier

1Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden

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Stina Syvänen

1Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden

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Greta Hultqvist

2Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden

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Xiaotian T. Fang

1Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden

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Sahar Roshanbin

1Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden

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Lars Lannfelt

1Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden

3BioArctic AB, Stockholm, Sweden; and

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Ulf Neumann

4Neuroscience Research, Novartis Institutes for BioMedical Research, Basel, Switzerland

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Dag Sehlin

1Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden

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Journal of Nuclear Medicine

Vol. 59, Issue 12

December 1, 2018

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Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

Silvio R. Meier, Stina Syvänen, Greta Hultqvist, Xiaotian T. Fang, Sahar Roshanbin, Lars Lannfelt, Ulf Neumann, Dag Sehlin

Journal of Nuclear Medicine Dec 2018, 59 (12) 1885-1891; DOI: 10.2967/jnumed.118.213140

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Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

Silvio R. Meier, Stina Syvänen, Greta Hultqvist, Xiaotian T. Fang, Sahar Roshanbin, Lars Lannfelt, Ulf Neumann, Dag Sehlin

Journal of Nuclear Medicine Dec 2018, 59 (12) 1885-1891; DOI: 10.2967/jnumed.118.213140

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Keywords

Alzheimer’s disease
positron emission tomography (PET)
Antibody-based radioligand
BACE-1 inhibitor NB-360
amyloid-β

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Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

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