Alteration of Monoamine Receptor Activity and Glucose Metabolism in Pediatric Patients with Anticonvulsant-Induced Cognitive Impairment

Yuankai Zhu; Jianhua Feng; Jianfeng Ji; Haifeng Hou; Lin Chen; Shuang Wu; Qing Liu; Qiong Yao; Peizhen Du; Kai Zhang; Qing Chen; Zexin Chen; Hong Zhang; Mei Tian

doi:10.2967/jnumed.116.189290

Research ArticleNeurology

Alteration of Monoamine Receptor Activity and Glucose Metabolism in Pediatric Patients with Anticonvulsant-Induced Cognitive Impairment

Yuankai Zhu, Jianhua Feng, Jianfeng Ji, Haifeng Hou, Lin Chen, Shuang Wu, Qing Liu, Qiong Yao, Peizhen Du, Kai Zhang, Qing Chen, Zexin Chen, Hong Zhang and Mei Tian

Journal of Nuclear Medicine September 2017, 58 (9) 1490-1497; DOI: https://doi.org/10.2967/jnumed.116.189290

Yuankai Zhu

1Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China

2Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China

3Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China

4Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China

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Jianhua Feng

5Department of Paediatrics, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China; and

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Jianfeng Ji

1Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China

2Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China

3Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China

4Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China

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Haifeng Hou

1Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China

2Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China

3Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China

4Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China

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Lin Chen

1Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China

2Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China

3Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China

4Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China

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Shuang Wu

1Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China

2Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China

3Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China

4Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China

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Qing Liu

1Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China

2Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China

3Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China

4Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China

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Qiong Yao

1Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China

2Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China

3Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China

4Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China

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Peizhen Du

1Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China

2Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China

3Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China

4Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China

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Kai Zhang

1Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China

2Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China

3Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China

4Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China

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Qing Chen

1Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China

2Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China

3Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China

4Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China

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Zexin Chen

6Department of Clinical Epidemiology & Biostatistics, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China

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Hong Zhang

1Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China

2Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China

3Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China

4Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China

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Mei Tian

1Department of Nuclear Medicine, The Second Hospital of Zhejiang University School of Medicine, Hangzhou, China

2Zhejiang University Medical PET Centre, Zhejiang University, Hangzhou, China

3Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, China

4Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, China

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Alteration of Monoamine Receptor Activity and Glucose Metabolism in Pediatric Patients with Anticonvulsant-Induced Cognitive Impairment

Yuankai Zhu, Jianhua Feng, Jianfeng Ji, Haifeng Hou, Lin Chen, Shuang Wu, Qing Liu, Qiong Yao, Peizhen Du, Kai Zhang, Qing Chen, Zexin Chen, Hong Zhang, Mei Tian

Journal of Nuclear Medicine Sep 2017, 58 (9) 1490-1497; DOI: 10.2967/jnumed.116.189290

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Alteration of Monoamine Receptor Activity and Glucose Metabolism in Pediatric Patients with Anticonvulsant-Induced Cognitive Impairment

Yuankai Zhu, Jianhua Feng, Jianfeng Ji, Haifeng Hou, Lin Chen, Shuang Wu, Qing Liu, Qiong Yao, Peizhen Du, Kai Zhang, Qing Chen, Zexin Chen, Hong Zhang, Mei Tian

Journal of Nuclear Medicine Sep 2017, 58 (9) 1490-1497; DOI: 10.2967/jnumed.116.189290

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Keywords

epilepsy
cognition
anticonvulsant
monoamine receptor
positron emission tomography (PET)

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