Skip to main content

Main menu

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI

User menu

  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Nuclear Medicine
  • SNMMI
    • JNM
    • JNMT
    • SNMMI Journals
    • SNMMI
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Journal of Nuclear Medicine

Advanced Search

  • Home
  • Content
    • Current
    • Ahead of print
    • Past Issues
    • JNM Supplement
    • SNMMI Annual Meeting Abstracts
    • Continuing Education
    • JNM Podcasts
  • Subscriptions
    • Subscribers
    • Institutional and Non-member
    • Rates
    • Journal Claims
    • Corporate & Special Sales
  • Authors
    • Submit to JNM
    • Information for Authors
    • Assignment of Copyright
    • AQARA requirements
  • Info
    • Reviewers
    • Permissions
    • Advertisers
  • About
    • About Us
    • Editorial Board
    • Contact Information
  • More
    • Alerts
    • Feedback
    • Help
    • SNMMI Journals
  • View or Listen to JNM Podcast
  • Visit JNM on Facebook
  • Join JNM on LinkedIn
  • Follow JNM on Twitter
  • Subscribe to our RSS feeds
Research ArticleInflammation/Infection

In Vivo Hypoxia PET Imaging Quantifies the Severity of Arthritic Joint Inflammation in Line with Overexpression of Hypoxia-Inducible Factor and Enhanced Reactive Oxygen Species Generation

Kerstin Fuchs, Anna Kuehn, Moritz Mahling, Philipp Guenthoer, Andreas Hector, Johannes Schwenck, Dominik Hartl, Stefan Laufer, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Gerald Reischl, Martin Röcken, Bernd J. Pichler and Manfred Kneilling
Journal of Nuclear Medicine May 2017, 58 (5) 853-860; DOI: https://doi.org/10.2967/jnumed.116.185934
Kerstin Fuchs
1Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University Tuebingen, Tuebingen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anna Kuehn
1Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University Tuebingen, Tuebingen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Moritz Mahling
1Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University Tuebingen, Tuebingen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Philipp Guenthoer
1Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University Tuebingen, Tuebingen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andreas Hector
2Children’s Hospital of the Eberhard Karls University Tuebingen, Tuebingen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Johannes Schwenck
1Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University Tuebingen, Tuebingen, Germany
3Department of Nuclear Medicine and Clinical Molecular Imaging, Eberhard Karls University, Tuebingen, Tuebingen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dominik Hartl
2Children’s Hospital of the Eberhard Karls University Tuebingen, Tuebingen, Germany
4Immunology, Inflammation and Infectious Diseases Discovery and Translational Area, Roche Pharma Research & Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stefan Laufer
5Department of Pharmacy & Biochemistry, Eberhard Karls University Tuebingen, Tuebingen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ursula Kohlhofer
6Institute of Pathology and Neuropathology, Eberhard Karls University Tuebingen and Comprehensive Cancer Center, University Hospital Tuebingen, Tuebingen, Germany; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leticia Quintanilla-Martinez
6Institute of Pathology and Neuropathology, Eberhard Karls University Tuebingen and Comprehensive Cancer Center, University Hospital Tuebingen, Tuebingen, Germany; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gerald Reischl
1Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University Tuebingen, Tuebingen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martin Röcken
7Department of Dermatology, Eberhard Karls University Tuebingen, Tuebingen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bernd J. Pichler
1Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University Tuebingen, Tuebingen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Manfred Kneilling
1Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University Tuebingen, Tuebingen, Germany
7Department of Dermatology, Eberhard Karls University Tuebingen, Tuebingen, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • PDF
Loading

Article Information

vol. 58 no. 5 853-860
DOI 
https://doi.org/10.2967/jnumed.116.185934
PubMed 
28183987

Published By 
Society of Nuclear Medicine
Print ISSN 
0161-5505
Online ISSN 
2159-662X
History 
  • Received for publication October 24, 2016
  • Accepted for publication January 11, 2017
  • Published online May 1, 2017.

Article Versions

  • previous version (February 9, 2017 - 04:22).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2017 by the Society of Nuclear Medicine and Molecular Imaging.

Author Information

  1. Kerstin Fuchs1,
  2. Anna Kuehn1,
  3. Moritz Mahling1,
  4. Philipp Guenthoer1,
  5. Andreas Hector2,
  6. Johannes Schwenck1,3,
  7. Dominik Hartl2,4,
  8. Stefan Laufer5,
  9. Ursula Kohlhofer6,
  10. Leticia Quintanilla-Martinez6,
  11. Gerald Reischl1,
  12. Martin Röcken7,
  13. Bernd J. Pichler1 and
  14. Manfred Kneilling1,7
  1. 1Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University Tuebingen, Tuebingen, Germany
  2. 2Children’s Hospital of the Eberhard Karls University Tuebingen, Tuebingen, Germany
  3. 3Department of Nuclear Medicine and Clinical Molecular Imaging, Eberhard Karls University, Tuebingen, Tuebingen, Germany
  4. 4Immunology, Inflammation and Infectious Diseases Discovery and Translational Area, Roche Pharma Research & Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland
  5. 5Department of Pharmacy & Biochemistry, Eberhard Karls University Tuebingen, Tuebingen, Germany
  6. 6Institute of Pathology and Neuropathology, Eberhard Karls University Tuebingen and Comprehensive Cancer Center, University Hospital Tuebingen, Tuebingen, Germany; and
  7. 7Department of Dermatology, Eberhard Karls University Tuebingen, Tuebingen, Germany
  1. For correspondence or reprints contact: Manfred Kneilling, Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy and Department of Dermatology, Eberhard Karls University Tuebingen, Roentgenweg 13, 72076 Tuebingen, Germany. E-mail: manfred.kneilling{at}med.uni-tuebingen.de
View Full Text

Statistics from Altmetric.com

Cited By...

  • 20 Citations
  • 18 Citations
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Role of reactive oxygen species and mitochondrial damage in rheumatoid arthritis and targeted drugs
    Weiyao Jing, Cui Liu, Chenghong Su, Limei Liu, Ping Chen, Xiangjun Li, Xinghua Zhang, Bo Yuan, Haidong Wang, Xiaozheng Du
    Frontiers in Immunology 2023 14
  • PET/MRI in Infection and Inflammation
    Martina Sollini, Raffaella Berchiolli, Margarita Kirienko, Alexia Rossi, A.W.J.M. Glaudemans, Riemer Slart, Paola Anna Erba
    Seminars in Nuclear Medicine 2018 48 3
  • Clinical imaging of hypoxia: Current status and future directions
    Paul Bonnitcha, Stuart Grieve, Gemma Figtree
    Free Radical Biology and Medicine 2018 126
  • Photoacoustic imaging of synovial tissue hypoxia in experimental post-traumatic osteoarthritis
    Zhongyu Liu, Manting Au, Xuan Wang, Pok-Man Boris Chan, Puxiang Lai, Lei Sun, Yongping Zheng, Limin Rong, Chunyi Wen
    Progress in Biophysics and Molecular Biology 2019 148
  • Novel positron emission tomography tracers for imaging of rheumatoid arthritis
    Jeffrey M.A. van der Krogt, Wouter H. van Binsbergen, Conny J. van der Laken, Sander W. Tas
    Autoimmunity Reviews 2021 20 3
  • Systematic Review: Targeted Molecular Imaging of Angiogenesis and Its Mediators in Rheumatoid Arthritis
    Fatemeh Khodadust, Aiarpi Ezdoglian, Maarten M. Steinz, Judy R. van Beijnum, Gerben J. C. Zwezerijnen, Gerrit Jansen, Sander W. Tas, Conny J. van der Laken
    International Journal of Molecular Sciences 2022 23 13
  • Evaluation of the therapeutic potential of the selective p38 MAPK inhibitor Skepinone-L and the dual p38/JNK 3 inhibitor LN 950 in experimental K/BxN serum transfer arthritis
    Philipp Guenthoer, Kerstin Fuchs, Gerald Reischl, Leticia Quintanilla-Martinez, Irene Gonzalez-Menendez, Stefan Laufer, Bernd J. Pichler, Manfred Kneilling
    Inflammopharmacology 2019 27 6
  • Lactate Production Precedes Inflammatory Cell Recruitment in Arthritic Ankles: an Imaging Study
    Marie-Aline Neveu, Nicolas Beziere, Rolf Daniels, Caroline Bouzin, Arnaud Comment, Johannes Schwenck, Kerstin Fuchs, Manfred Kneilling, Bernd J. Pichler, Andreas M. Schmid
    Molecular Imaging and Biology 2020 22 5
  • Targeting glycolytic pathway in fibroblast-like synoviocytes for rheumatoid arthritis therapy: challenges and opportunities
    Qianwei Li, Yuehong Chen, Huan Liu, Yunru Tian, Geng Yin, Qibing Xie
    Inflammation Research 2023 72 12
  • EANM recommendations based on systematic analysis of small animal radionuclide imaging in inflammatory musculoskeletal diseases
    Erik H. J. G. Aarntzen, Edel Noriega-Álvarez, Vera Artiko, André H. Dias, Olivier Gheysens, Andor W. J. M. Glaudemans, Chiara Lauri, Giorgio Treglia, Tim van den Wyngaert, Fijs W. B. van Leeuwen, Samantha Y. A. Terry
    EJNMMI Research 2021 11 1

Article usage

Article usage: March 2017 to May 2025

AbstractFullPdf
Feb 2017416059
Mar 2017173037
Apr 201780015
May 20178211953
Jun 20171522223
Jul 2017881210
Aug 2017681516
Sep 201769929
Oct 201782913
Nov 2017603532
Dec 2017422812
Jan 2018512923
Feb 2018351912
Mar 2018551717
Apr 2018461214
May 2018421515
Jun 20182846
Jul 2018241112
Aug 2018191515
Sep 2018342115
Oct 201839159
Nov 201819135
Dec 2018181112
Jan 2019242012
Feb 2019352914
Mar 201926258
Apr 2019251215
May 201930136
Jun 20192299
Jul 201930712
Aug 2019311116
Sep 20192787
Oct 201921167
Nov 2019251111
Dec 2019292821
Jan 20202688
Feb 2020261469
Mar 2020352123
Apr 202024155
May 20202958
Jun 20203274
Jul 202017810
Aug 202025316
Sep 2020251315
Oct 202039818
Nov 2020231610
Dec 20202379
Jan 2021172120
Feb 2021232920
Mar 2021242118
Apr 2021162212
May 2021103232
Jun 2021112527
Jul 202181415
Aug 2021111516
Sep 202120209
Oct 2021602841
Nov 2021191520
Dec 2021193421
Jan 2022171920
Feb 2022182518
Mar 2022243237
Apr 2022372025
May 2022212522
Jun 20225712
Jul 202282712
Aug 2022303611
Sep 2022281513
Oct 2022132116
Nov 202251915
Dec 20229151
Jan 202310209
Feb 20232139
Mar 202391510
Apr 202382015
May 20235169
Jun 2023588
Jul 2023097
Aug 2023567
Sep 20231156
Oct 202352311
Nov 20235125
Dec 20233278
Jan 202471912
Feb 202452014
Mar 2024151116
Apr 202471221
May 202412713
Jun 202449817
Jul 202482812
Aug 202482614
Sep 202473215
Oct 202453322
Nov 20242219
Dec 20245247
Jan 202502717
Feb 2025514920
Mar 202546818
Apr 202553023
PreviousNext
Back to top

In this issue

Journal of Nuclear Medicine: 58 (5)
Journal of Nuclear Medicine
Vol. 58, Issue 5
May 1, 2017
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Journal of Nuclear Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
In Vivo Hypoxia PET Imaging Quantifies the Severity of Arthritic Joint Inflammation in Line with Overexpression of Hypoxia-Inducible Factor and Enhanced Reactive Oxygen Species Generation
(Your Name) has sent you a message from Journal of Nuclear Medicine
(Your Name) thought you would like to see the Journal of Nuclear Medicine web site.
Citation Tools
In Vivo Hypoxia PET Imaging Quantifies the Severity of Arthritic Joint Inflammation in Line with Overexpression of Hypoxia-Inducible Factor and Enhanced Reactive Oxygen Species Generation
Kerstin Fuchs, Anna Kuehn, Moritz Mahling, Philipp Guenthoer, Andreas Hector, Johannes Schwenck, Dominik Hartl, Stefan Laufer, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Gerald Reischl, Martin Röcken, Bernd J. Pichler, Manfred Kneilling
Journal of Nuclear Medicine May 2017, 58 (5) 853-860; DOI: 10.2967/jnumed.116.185934

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
In Vivo Hypoxia PET Imaging Quantifies the Severity of Arthritic Joint Inflammation in Line with Overexpression of Hypoxia-Inducible Factor and Enhanced Reactive Oxygen Species Generation
Kerstin Fuchs, Anna Kuehn, Moritz Mahling, Philipp Guenthoer, Andreas Hector, Johannes Schwenck, Dominik Hartl, Stefan Laufer, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Gerald Reischl, Martin Röcken, Bernd J. Pichler, Manfred Kneilling
Journal of Nuclear Medicine May 2017, 58 (5) 853-860; DOI: 10.2967/jnumed.116.185934
Twitter logo Facebook logo LinkedIn logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSION
    • DISCLOSURE
    • Acknowledgments
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • PDF

Related Articles

  • This Month in JNM
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

Inflammation/Infection

  • First-in-Humans Study of 68Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1
Show more Inflammation/Infection

Basic

  • Dopamine D1 Receptor Agonist PET Tracer Development: Assessment in Nonhuman Primates
  • Optical Navigation of the Drop-In γ-Probe as a Means to Strengthen the Connection Between Robot-Assisted and Radioguided Surgery
  • Synthesis and Preclinical Evaluation of a 68Ga-Labeled Adnectin, 68Ga-BMS-986192, as a PET Agent for Imaging PD-L1 Expression
Show more Basic

Similar Articles

Keywords

  • rheumatoid arthritis
  • In vivo hypoxia imaging
  • PET
  • HIF
  • ROS
SNMMI

© 2025 SNMMI

Powered by HighWire