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Research ArticlePhysics/Instrumentation

PET/MRI in the Presence of Metal Implants: Completion of the Attenuation Map from PET Emission Data

Niccolo Fuin, Stefano Pedemonte, Onofrio A. Catalano, David Izquierdo-Garcia, Andrea Soricelli, Marco Salvatore, Keith Heberlein, Jacob M. Hooker, Koen Van Leemput and Ciprian Catana
Journal of Nuclear Medicine May 2017, 58 (5) 840-845; DOI: https://doi.org/10.2967/jnumed.116.183343
Niccolo Fuin
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts
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Stefano Pedemonte
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts
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Onofrio A. Catalano
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts
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David Izquierdo-Garcia
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts
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Andrea Soricelli
2SDN—Istituto di Ricerca Diagnostica e Nucleare, IRCCS, Naples, Italy
3University of Naples Parthenope, Department of Motor Sciences and Healthiness, Naples, Italy
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Marco Salvatore
2SDN—Istituto di Ricerca Diagnostica e Nucleare, IRCCS, Naples, Italy
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Keith Heberlein
4Siemens Medical Solutions USA, MR RD Collaborations, Charlestown, Massachusetts; and
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Jacob M. Hooker
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts
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Koen Van Leemput
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts
5Department of Applied Mathematics and Computer Science, Technical University of Denmark, Lyngby, Denmark
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Ciprian Catana
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts
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  • FIGURE 1.
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    FIGURE 1.

    Uniform 18F-FDG phantom with cobalt–chromium alloy implant. (A) CT μ-map (left) and IPAC μ-map (right) are shown. (B) Corresponding LAC profiles are shown (CT μ-map in blue and IPAC μ-map in red).

  • FIGURE 2.
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    FIGURE 2.

    Patient presenting right hip cobalt–chromium alloy endoprosthesis (patient 1). Dixon (A), CT (B), and IPAC (C) μ-maps are shown. The 3 columns show (from left to right) sagittal, coronal, and axial planes.

  • FIGURE 3.
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    FIGURE 3.

    Patient presenting titanium spinal implant and pedicle screws (patient 1B). Dixon (A), CT (B), and IPAC (C) μ-maps are shown. The 3 columns show (from left to right) sagittal, coronal, and axial planes.

  • FIGURE 4.
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    FIGURE 4.

    Reconstructed PET images corrected with the 3 AC methods for the validation subject of Figure 2. Dixon (A), thCT (B), and IPAC (C) μ-maps were, respectively, used for AC during reconstruction. (D) Corresponding radioactivity profiles are shown (Dixon in blue, thCT in black, and IPAC in red).

  • FIGURE 5.
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    FIGURE 5.

    Bland–Altman plots showing voxel-based comparisons (for all validation subjects) between PETDixon/PETthCT (A) and PETIPAC/PETthCT (B). Continuous red lines show mean, and dashed red lines show the of difference.

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    TABLE 1

    Data Acquisition Parameters, Implant Material Specifications, and Results for DSC and Mean LAC Analysis

    Patient no.CenterType of implantMaterial mean LACReconstructed mean LACDSCTotal prompts events
    1MartinosRight hip0.720.660.894.28E+08
    2SDN NapoliLeft hip0.360.320.808.55E+07
    3SDN NapoliBoth hips0.360.300.754.84E+07
    4SDN NapoliBoth hips0.360.310.752.70E+08
    5SDN NapoliRight hip0.360.310.692.48E+08
    6SDN NapoliBoth hips0.360.280.697.50E+07
    7SDN NapoliBoth hips0.360.280.793.54E+07
    8SDN NapoliLeft femur0.360.260.651.07E+08
    1BMartinosBack screws0.360.320.722.33E+08
    2BSDN NapoliBack screws0.360.330.661.21E+08
    9MartinosBack screws0.360.270.652.40E+08
    10MartinosDental—0.290.641.80E+08
    11MartinosDental—0.280.661.13E+08
    PhantomMartinosHip0.710.700.901.92E+08

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Journal of Nuclear Medicine: 58 (5)
Journal of Nuclear Medicine
Vol. 58, Issue 5
May 1, 2017
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PET/MRI in the Presence of Metal Implants: Completion of the Attenuation Map from PET Emission Data
Niccolo Fuin, Stefano Pedemonte, Onofrio A. Catalano, David Izquierdo-Garcia, Andrea Soricelli, Marco Salvatore, Keith Heberlein, Jacob M. Hooker, Koen Van Leemput, Ciprian Catana
Journal of Nuclear Medicine May 2017, 58 (5) 840-845; DOI: 10.2967/jnumed.116.183343

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PET/MRI in the Presence of Metal Implants: Completion of the Attenuation Map from PET Emission Data
Niccolo Fuin, Stefano Pedemonte, Onofrio A. Catalano, David Izquierdo-Garcia, Andrea Soricelli, Marco Salvatore, Keith Heberlein, Jacob M. Hooker, Koen Van Leemput, Ciprian Catana
Journal of Nuclear Medicine May 2017, 58 (5) 840-845; DOI: 10.2967/jnumed.116.183343
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Keywords

  • metal implant
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  • MLAA
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